A drug interaction study investigating the effect of Rifabutin on the pharmacokinetics of Maraviroc in healthy subjects

Autor: Salmaan Kanji, Isabelle Seguin, C. la Porte, M. Dennehy, Guijin Zhang, M. Ghannad, Elham Sabri, D. W. Cameron, Ranjeeta Mallick, D. Tardiff

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0223969 (2019)
PLoS ONE

Effects of steady-state rifabutin on the pharmacokinetics of steady-state maraviroc were investigated in fourteen healthy adult female and male volunteers. Maraviroc 300 mg twice daily (BID) was given orally with food for fifteen days. On day six, ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddea84e05cb923e8e5a567160e772789
https://doaj.org/article/007c10680b4842e7946c9380b2a5850c

Absence of circadian variation in the pharmacokinetics of lopinavir/ritonavir given as a once daily dosing regimen in HIV-1-infected patients

Autor: Marc Bourbeau, G. E. Garber, Isabelle Seguin, R. P. G. van Heeswijk, Pierre Giguère, D. W. Cameron

Publikováno v: British Journal of Clinical Pharmacology. 59:398-404

Aims To compare the pharmacokinetics of lopinavir/ritonavir (LPV/r) 800/200 mg administered once daily in the morning compared with the evening. Methods This was a randomized, two-way, cross-over study in HIV+ subjects. In each subject the pharmacoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375459d90d8c0f3bdc05e25fec6911fa
https://doi.org/10.1111/j.1365-2125.2005.02337.x

The effect of β-carotene supplementation on the pharmacokinetics of nelfinavir and its active metabolite M8 in HIV-1-infected patients

Autor: Humayoun Akhtar, Bobby M. Chauhan, Mohammed Rachid Boulassel, David M. Burger, Isabelle Seguin, Marc Bourbeau, Lina DelBalso, Nancy L. Sheehan, Brian C. Foster, Rolf P G Van Heeswijk, Richard G. Lalonde, Neera Singhal, Donald William Cameron

Publikováno v: Molecules
Molecules, Vol 17, Iss 1, Pp 688-702 (2012)
Molecules; Volume 17; Issue 1; Pages: 688-702
Molecules, 17, 688-702
Molecules, 17, 1, pp. 688-702

Contains fulltext : 109786.pdf (Publisher’s version ) (Open Access) beta-Carotene supplements are often taken by individuals living with HIV-1. Contradictory results from in vitro studies suggest that beta-carotene may inhibit or induce cytochrome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074f1a58075e2d9d54d47bda6493bf9b
https://pubmed.ncbi.nlm.nih.gov/22241465

Effect of high-dose vitamin C on hepatic cytochrome P450 3A4 activity

Autor: Edward J Mills, Rolf P. G. van Heeswijk, Elizabeth J. Phillips, Curtis Cooper, Brian C. Foster, Isabelle Seguin, Farshad H. Shirazi, Bobby M. Chauhan

Publikováno v: Pharmacotherapy. 25(12)

Study Objectives. To investigate the effect of high-dose vitamin C on cytochrome P450 (CYP) 3A4 activity, and to evaluate possible sex-specific effects on CYP3A4 activity. Design. Single-center longitudinal study. Setting. Tertiary- and specialty-car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad7a09928ed9feb73fb0be30247bbc5
https://pubmed.ncbi.nlm.nih.gov/16305291

The pharmacokinetics of nelfinavir and M8 during pregnancy and post partum

Autor: Yasmin Khaliq, Keith Gallicano, Marc Bourbeau, Elizabeth J. Phillips, D. William Cameron, Rolf P. G. van Heeswijk, Isabelle Seguin

Publikováno v: Clinical pharmacology and therapeutics. 76(6)

Objective: The objective of this study was to explore the pharmacokinetics of nelfinavir and its active metabolite hydroxy-t-butylamidenelfinavir (M8) during pregnancy and post partum. Methods: Eleven human immunodeficiency virus type 1–infected pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861abfcd7662b4f88d9a0f612128c955
https://pubmed.ncbi.nlm.nih.gov/15592330