Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Isabelle Schreiber"'
Autor:
Marc Bianciotto, Lionel Colliandre, Kun Mi, Isabelle Schreiber, Cécile Delorme, Stéphanie Vougier, Hervé Minoux
Publikováno v:
Artificial Intelligence in the Life Sciences, Vol 3, Iss , Pp 100063- (2023)
One of the common strategies to identify novel chemical matter in drug discovery consists in performing a High Throughput Screening (HTS). However, the large amount of data generated at the dose-response (DR) step of an HTS campaign requires a carefu
Externí odkaz:
https://doaj.org/article/4b1eeeb21d1d47e49e0b39e46a0c147d
Autor:
Gina Dörpholz, Arunima Murgai, Jerome Jatzlau, Daniel Horbelt, Mohammad Poorgholi Belverdi, Christina Heroven, Isabelle Schreiber, Gisela Wendel, Karen Ruschke, Sigmar Stricker, Petra Knaus
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract Elaborate regulatory networks of the Bone Morphogenetic Protein (BMP) pathways ensure precise signalling outcome during cell differentiation and tissue homeostasis. Here, we identified IRS4 as a novel regulator of BMP signal transduction and
Externí odkaz:
https://doaj.org/article/1eb3e5fa24f24e5eb5f151ca67e39838
Autor:
Petra Knaus, Gina Dörpholz, Christina Heroven, Gisela Wendel, Mohammad Poorgholi Belverdi, Arunima Murgai, Jerome Jatzlau, Sigmar Stricker, Isabelle Schreiber, Daniel Horbelt, Karen Ruschke
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Scientific Reports
Scientific Reports
Elaborate regulatory networks of the Bone Morphogenetic Protein (BMP) pathways ensure precise signalling outcome during cell differentiation and tissue homeostasis. Here, we identified IRS4 as a novel regulator of BMP signal transduction and provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecaa649c711e0ef956f3beecc1753e2
https://doaj.org/article/1eb3e5fa24f24e5eb5f151ca67e39838
https://doaj.org/article/1eb3e5fa24f24e5eb5f151ca67e39838
Autor:
Gina Dörpholz, Cory Thomas Lee, Karen Ruschke, Josef Köhrle, Nancy Schanze, Claus-Eric Ott, Petra Knaus, Isabelle Schreiber, Bjørt K Kragesteen, Stefan Mundlos
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Insulin-resistance is the main cause of type 2 diabetes. Here we describe the identification and characterization of BMP2 and BMP6 as new insulin-sensitizing growth factors in mature adipocytes. We show that BMP2 and BMP6 lead to enhanced insulin-med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d8bce3df94e0f6ec905b37532e0ba8
https://doi.org/10.1038/s41598-017-17595-5
https://doi.org/10.1038/s41598-017-17595-5
Publikováno v:
L'Observatoire. :74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6110803473cba2ad24c3078c5e726b80
https://doi.org/10.3917/lobs.053.0074
https://doi.org/10.3917/lobs.053.0074
Autor:
Judith Sudhalter, Qiang Gao, Stephan Reiling, Isabelle Schreiber, Albane Courjaud, Jack Pollard, Eric Yang, Luc Bonnet, Joshua Murtie, Carlos Garcia-Echeverria, Matthieu Barrague, Fangxian Sun, Timothy He, Claudine Grepin, Monsif Bouaboula, Francisco Adrian, Bailin Zhang, Malvika Koundinya, M. Paola Castaldi, Gaetan Touyer, Bruno Lionne, Mark Munson, Richard Newcombe, Isabelle Menguy, Rosalia Arrebola, Stuart Licht, Yanjun Wang, Christopher Winter, Ronald Tomlinson, Patricia Gee, Hui Cao, Christelle Perrault, Stephanie Vougier, Aaron J. Morris, David Harper, Brigitte Benhamou, Hong Cheng, Ivan Cornella-Taracido, Daniel Simard
Publikováno v:
Cell Chemical Biology. 25:705-717.e11
Summary Activating KRAS mutations are major oncogenic drivers in multiple tumor types. Synthetic lethal screens have previously been used to identify targets critical for the survival of KRAS mutant cells, but their application to drug discovery has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8adef1cb348b566c4cf6075801bafc
https://doi.org/10.1016/j.chembiol.2018.03.005
https://doi.org/10.1016/j.chembiol.2018.03.005
Autor:
Hakan Dortay, Karen Ruschke, Julia Märk, Jan Laufer, Taimoor H. Qazi, Andrea Sass, Matthias Pumberger, Isabelle Schreiber
Publikováno v:
Photons Plus Ultrasound: Imaging and Sensing 2014
The capability to image stem cells in vivo in small animal models over extended periods of time is important to furthering our understanding of the processes involved in tissue regeneration. Photoacoustic imaging is suited to this application as it c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e91853d301912eb17a36e42e5c54ce1
Autor:
Brigitte Benhamou, Ivan Cornella-Taracido, Christelle Perrault, Stephanie Vougier, Bruno Lionne, Ronald Tomlinson, Francisco Adrian, Hui Cao, David P. Harper, Maria Paola Castaldi, Isabelle Schreiber, Jack Pollard, Malvika Koundinya, Monsif Bouaboula, Albane Courjaud, Gaetan Touyer, Rosalia Arrebola, Luc Bonnet, Aaron J. Morris, Daniel Simard, Stephan Reiling, Judith Sudhalter, Carlos Garcia-Echeverria, Claudine Grepin, Isabelle Menguy
Publikováno v:
Cancer Research. 73:2243-2243
Activating KRAS mutations are oncogenic and prevalent in multiple tumor types, being found in as high as 90% of pancreatic carcinomas and 50% of colorectal carcinomas. In spite of its attractiveness for therapeutic intervention to date no KRAS-target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::553379a34eabd08813663c0a4b846c15
https://doi.org/10.1158/1538-7445.am2013-2243
https://doi.org/10.1158/1538-7445.am2013-2243