Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Isabelle S. Lucet"'
Autor:
Lung-Yu Liang, Niall D. Geoghegan, Michael Mlodzianoski, Andrew Leis, Lachlan W. Whitehead, Minglyanna G. Surudoi, Samuel N. Young, Peter Janes, Doulin Shepherd, Debnath Ghosal, Kelly L. Rogers, James M. Murphy, Isabelle S. Lucet
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract EphB6 is an understudied ephrin receptor tyrosine pseudokinase that is downregulated in multiple types of metastatic cancers. Unlike its kinase-active counterparts which autophosphorylate and transmit signals upon intercellular interaction,
Externí odkaz:
https://doaj.org/article/57b7b70f20284071a21e40f20591480e
Autor:
Michael J. Roy, Minglyanna G. Surudoi, Ashleigh Kropp, Jianmei Hou, Weiwen Dai, Joshua M. Hardy, Lung-Yu Liang, Thomas R. Cotton, Bernhard C. Lechtenberg, Toby A. Dite, Xiuquan Ma, Roger J. Daly, Onisha Patel, Isabelle S. Lucet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract PEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their expression level is associated with several aggressive c
Externí odkaz:
https://doaj.org/article/5b2aa666db0e4b438310eae34e24f33b
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Patel et al. report crystal structures of the kinase domain of Doublecortin-like kinase 1 (DCLK1) in complex with a potent inhibitor and its precursors. Their structural study reveals insights into the mode of action of the inhibitor DCLK1-IN-1 and s
Externí odkaz:
https://doaj.org/article/6b6a664c847645569a2bc4e72fd9c9cb
Autor:
Laura Ramos Garcia, Tencho Tenev, Richard Newman, Rachel O. Haich, Gianmaria Liccardi, Sidonie Wicky John, Alessandro Annibaldi, Lu Yu, Mercedes Pardo, Samuel N. Young, Cheree Fitzgibbon, Winnie Fernando, Naomi Guppy, Hyojin Kim, Lung-Yu Liang, Isabelle S. Lucet, Andrew Kueh, Ioannis Roxanis, Patrycja Gazinska, Martin Sims, Tomoko Smyth, George Ward, John Bertin, Allison M. Beal, Brad Geddes, Jyoti S. Choudhary, James M. Murphy, K. Aurelia Ball, Jason W. Upton, Pascal Meier
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Necroptosis is a form of cell death characterized by membrane rupture via MLKL oligomerization, although mechanistic details remain unclear. Here, the authors show that MLKL ubiquitylation of K219 facilitates high-order membrane assembly and subseque
Externí odkaz:
https://doaj.org/article/028b10c801d94af293be6d1707508113
Autor:
Annalisa L. E. Carli, Joshua M. Hardy, Hanadi Hoblos, Matthias Ernst, Isabelle S. Lucet, Michael Buchert
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 990 (2023)
Doublecortin-like kinase 1 (DCLK1) is a functional serine/threonine (S/T)-kinase and a member of the doublecortin family of proteins which are characterized by their ability to bind to microtubules (MTs). DCLK1 is a proposed cancer driver gene, and i
Externí odkaz:
https://doaj.org/article/e3d165ad1af54d03b44552f5860586ff
Autor:
Michael R. Oliver, Christopher R. Horne, Safal Shrestha, Jeremy R. Keown, Lung-Yu Liang, Samuel N. Young, Jarrod J. Sandow, Andrew I. Webb, David C. Goldstone, Isabelle S. Lucet, Natarajan Kannan, Peter Metcalf, James M. Murphy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The viral Protein Kinase-1 (PK-1) phosphorylates the regulatory protein p6.9, which facilitates baculoviral genome release. Here, the authors combine X-ray crystallography with biophysical and biochemical analyses as well as molecular dynamics simula
Externí odkaz:
https://doaj.org/article/68962591ebc346e3865840990c4f686b
Autor:
Brad E. Sleebs, Kate E. Jarman, Sonja Frolich, Wilson Wong, Julie Healer, Weiwen Dai, Isabelle S. Lucet, Danny W. Wilson, Alan F. Cowman
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 14, Iss , Pp 188-200 (2020)
The P. falciparum parasite, responsible for the disease in humans known as malaria, must invade erythrocytes to provide an environment for self-replication and survival. For invasion to occur, the parasite must engage several ligands on the host eryt
Externí odkaz:
https://doaj.org/article/569114d1c7544c93998b5a563c52ddb6
Autor:
Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Wayland Yeung, Diane Coursier, Richard W. Birkinshaw, Jarrod J. Sandow, Wil I. L. Lehmann, Lung-Yu Liang, Isabelle S. Lucet, James D. Chalmers, Wayne M. Patrick, Natarajan Kannan, Emma J. Petrie, Peter E. Czabotar, James M. Murphy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The necroptotic cell death pathway involves signaling through pseudokinases. Here the authors define the structural determinants of species specificity in necroptosis signaling mediated by the essential necroptotic effector pseudokinase, Mixed Lineag
Externí odkaz:
https://doaj.org/article/b93b0f25bce74b3387360f9736d00ebc
Autor:
Emma J. Petrie, Jarrod J. Sandow, Annette V. Jacobsen, Brian J. Smith, Michael D. W. Griffin, Isabelle S. Lucet, Weiwen Dai, Samuel N. Young, Maria C. Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D. Cowan, Joanne M. Hildebrand, Wilhelmus J. A. Kersten, Guillaume Lessene, John Silke, Peter E. Czabotar, Andrew I. Webb, James M. Murphy
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
RIPK3-mediated phosphorylation of the mixed lineage kinase domain-like (MLKL) pseudokinase is thought to be the trigger for MLKL activation during necroptotic signaling. Here the authors provide evidence that the transition of human MLKL from a monom
Externí odkaz:
https://doaj.org/article/15857781bc14483aa896810340066149
Autor:
Emma J. Petrie, Jarrod J. Sandow, Wil I.L. Lehmann, Lung-Yu Liang, Diane Coursier, Samuel N. Young, Wilhelmus J.A. Kersten, Cheree Fitzgibbon, André L. Samson, Annette V. Jacobsen, Kym N. Lowes, Amanda E. Au, Hélène Jousset Sabroux, Najoua Lalaoui, Andrew I. Webb, Guillaume Lessene, Gerard Manning, Isabelle S. Lucet, James M. Murphy
Publikováno v:
Cell Reports, Vol 28, Iss 13, Pp 3309-3319.e5 (2019)
Summary: Necroptotic cell death has been implicated in many human pathologies and is thought to have evolved as an innate immunity mechanism. The pathway relies on two key effectors: the kinase receptor-interacting protein kinase 3 (RIPK3) and the te
Externí odkaz:
https://doaj.org/article/14df649cd4e44fdaa93d570f9cab0dba