Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Isabelle Rouiller"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Cryo electron tomography (cryo-ET) allows observing macromolecular complexes in their native environment. The common routine of subtomogram averaging (STA) allows obtaining the three-dimensional (3D) structure of abundant macromolecular comp
Externí odkaz:
https://doaj.org/article/aa9c6eb282f24cbdaac3cbb9da277b47
Publikováno v:
BMC Molecular and Cell Biology, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Background The AAA + ATPase p97 is an essential unfoldase/segragase involved in a multitude of cellular processes. It functions as a molecular machine critical for protein homeostasis, homotypic membrane fusion events and organelle biogenesi
Externí odkaz:
https://doaj.org/article/bc26839163694a8dab145f158fab212e
Autor:
Sepideh Valimehr, Ashish Sethi, Manjari Shukla, Sudipta Bhattacharyya, Mohsen Kazemi, Isabelle Rouiller
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 737 (2023)
p97/VCP, a highly conserved type II ATPase associated with diverse cellular activities (AAA+ ATPase), is an important therapeutic target in the treatment of neurodegenerative diseases and cancer. p97 performs a variety of functions in the cell and fa
Externí odkaz:
https://doaj.org/article/54ef8b9b80094eeebc20a33126960bb5
Autor:
Michael Luke Carlson, John William Young, Zhiyu Zhao, Lucien Fabre, Daniel Jun, Jianing Li, Jun Li, Harveer Singh Dhupar, Irvin Wason, Allan T Mills, J Thomas Beatty, John S Klassen, Isabelle Rouiller, Franck Duong
Publikováno v:
eLife, Vol 7 (2018)
Membrane proteins are difficult to work with due to their insolubility in aqueous solution and quite often their poor stability in detergent micelles. Here, we present the peptidisc for their facile capture into water-soluble particles. Unlike the na
Externí odkaz:
https://doaj.org/article/0edeac83e53d4480a4c7cb9a8148089c
Autor:
Gian-Luca McLelland, Thomas Goiran, Wei Yi, Geneviève Dorval, Carol X Chen, Nadine D Lauinger, Andrea I Krahn, Sepideh Valimehr, Aleksandar Rakovic, Isabelle Rouiller, Thomas M Durcan, Jean-François Trempe, Edward A Fon
Publikováno v:
eLife, Vol 7 (2018)
Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnove
Externí odkaz:
https://doaj.org/article/2a20fbdecc3a4cceb1d095ef6f8f8d3b
Autor:
Kaustuv Basu, Driss Lajoie, Tristan Aumentado-Armstrong, Jin Chen, Roman I Koning, Blaise Bossy, Mihnea Bostina, Attila Sik, Ella Bossy-Wetzel, Isabelle Rouiller
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179397 (2017)
Mitochondria are dynamic organelles that continually adapt their morphology by fusion and fission events. An imbalance between fusion and fission has been linked to major neurodegenerative diseases, including Huntington's, Alzheimer's, and Parkinson'
Externí odkaz:
https://doaj.org/article/aa73bacff3b64d489b08eb67af5a6457
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24698 (2011)
Growth-arrest-specific 2 gene was originally identified in murine fibroblasts under growth arrest conditions. Furthermore, serum stimulation of quiescent, non-dividing cells leads to the down-regulation of gas2 and results in re-entry into the cell c
Externí odkaz:
https://doaj.org/article/0594c9bbd6074bcbbe11de1f35e026a6
Publikováno v:
PLoS Biology, Vol 3, Iss 11, p e383 (2005)
Actin branch junctions are conserved cytoskeletal elements critical for the generation of protrusive force during actin polymerization-driven cellular motility. Assembly of actin branch junctions requires the Arp2/3 complex, upon activation, to initi
Externí odkaz:
https://doaj.org/article/a8962dc2fdc14ce1bd03d5de51cce543
Cryo electron tomography (cryo-ET) allows observing macromolecular complexes in their native environment. The common routine of subtomogram averaging (STA) allows obtaining the three-dimensional (3D) structure of abundant macromolecular complexes, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14f3584a619c72af08b66431c974d9b7
https://doi.org/10.1101/2023.02.25.529934
https://doi.org/10.1101/2023.02.25.529934
Autor:
Rémi Vuillemot, Alex Mirzaei, Mohamad Harastani, Ilyes Hamitouche, Léo Fréchin, Bruno P. Klaholz, Osamu Miyashita, Florence Tama, Isabelle Rouiller, Slavica Jonic
Publikováno v:
Journal of Molecular Biology
Journal of Molecular Biology, 2023, pp.167951. ⟨10.1016/j.jmb.2023.167951⟩
Journal of Molecular Biology, 2023, pp.167951. ⟨10.1016/j.jmb.2023.167951⟩
International audience; This article presents an original approach for extracting atomic-resolution landscapes of continuous conformational variability of biomolecular complexes from cryo electron microscopy (cryo-EM) single particle images. This app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275c6ed1a84c7331563ef63aa5d597ae
https://doi.org/10.1016/j.jmb.2023.167951
https://doi.org/10.1016/j.jmb.2023.167951