Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Isabelle Robillard-Frayne"'
Autor:
Akihiro Yamashita, Olesia Ignatenko, Mai Nguyen, Raphaëlle Lambert, Kathleen Watt, Caroline Daneault, Isabelle Robillard-Frayne, Ivan Topisirovic, Christine Des Rosiers, Heidi M. McBride
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-18 (2023)
Abstract Peroxisomes play a central role in tuning metabolic and signaling programs in a tissue- and cell-type-specific manner. However, the mechanisms by which the status of peroxisomes is communicated and integrated into cellular signaling pathways
Externí odkaz:
https://doaj.org/article/be389da2b5fa47c08431bd76872c34a4
Autor:
Masaki Kajimoto, Muhammad Nuri, Nancy G. Isern, Isabelle Robillard‐Frayne, Christine Des Rosiers, Michael A. Portman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 17 (2019)
Background The right ventricle exposed to chronic pressure overload exhibits hypertrophy and decompensates when exposed to stress. We hypothesize that impaired ability to increase myocardial oxidative flux through pyruvate dehydrogenase leads to hype
Externí odkaz:
https://doaj.org/article/5a119be6fd98462c8ec2281f1c73586f
Autor:
Masaki Kajimoto, Muhammad Nuri, Nancy G. Isern, Isabelle Robillard‐Frayne, Christine Des Rosiers, Michael A. Portman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 11 (2018)
BackgroundSurgical palliation or repair of complex congenital heart disease in early infancy can produce right ventricular (RV) pressure overload, often leading to acute hemodynamic decompensation. The mechanisms causing this acute RV dysfunction rem
Externí odkaz:
https://doaj.org/article/fecd86782ac1476e992f45fce2dcb722
Autor:
Anne-Laure Castell, Alexis Vivoli, Trevor S. Tippetts, Isabelle Robillard Frayne, Zuraya Elisa Angeles, Valentine S. Moullé, Scott A. Campbell, Matthieu Ruiz, Julien Ghislain, Christine Des Rosiers, William L. Holland, Scott A. Summers, Vincent Poitout
Publikováno v:
Diabetes
Fatty acid (FA) signaling contributes to β-cell mass expansion in response to nutrient excess, but the underlying mechanisms are poorly understood. In the presence of elevated glucose, FA metabolism is shifted toward synthesis of complex lipids, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f835ed26cf03481d7214091f674b12e
https://doi.org/10.2337/figshare.19337828
https://doi.org/10.2337/figshare.19337828
Autor:
Shannon Hitchcock, Alvin D. Pewa, Eric B. Taylor, Lawrence R. Gray, Jonas Maximilian Marx, Isabelle Robillard-Frayne, Thomas Cassier, Rose McGlauflin, Fariba Tayyari, Paul V. Taufalele, Lauren Haff, Lynn M. Teesch, Jamie Soto, Peter A. Crawford, Kathy Zimmerman, Trevor Funari, Jennifer L. Stueve, Robert M. Weiss, Christine Des Rosiers, E. Douglas Lewandowski, E. Dale Abel, Yuan Zhang, James E. Cox, Adam J. Rauckhorst, Kevin D. Lin, William J. Kutschke, Patrycja Puchalska, Jared Rutter, Jesse D. Cochran, Kevin M. Kato
Publikováno v:
Nature metabolism
In addition to fatty acids, glucose and lactate are important myocardial substrates under physiologic and stress conditions. They are metabolized to pyruvate, which enters mitochondria via the mitochondrial pyruvate carrier (MPC) for citric acid cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3413162a397848a5e3eb89491638c1b3
https://doi.org/10.1038/s42255-020-00288-1
https://doi.org/10.1038/s42255-020-00288-1
Autor:
Julien Ghislain, William L. Holland, Anne-Laure Castell, Matthieu Ruiz, Alexis Vivoli, Isabelle Robillard Frayne, Valentine S. Moullé, Christine Des Rosiers, Vincent Poitout, Trevor S. Tippetts, Scott A. Summers
Fatty-acid (FA) signaling contributes to β-cell mass expansion in the face of nutrient excess, but the underlying mechanisms are poorly understood. Here we tested the hypothesis that sphingolipids, generated by the intracellular metabolism of FA, ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0aec7f9c63758ca153a751a5ea54e4e2
https://doi.org/10.1101/2021.07.16.452686
https://doi.org/10.1101/2021.07.16.452686
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 319(1)
One of the primary metabolic functions of a mature adipocyte is to supply energy via lipolysis, or the catabolism of stored lipids. Hormone-sensitive lipase (HSL) is a critical lipolytic enzyme, and its phosphorylation and subsequent activation by PK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b5a50ef5b43f0866bcbf7f3a336ca2
https://pubmed.ncbi.nlm.nih.gov/32369418
https://pubmed.ncbi.nlm.nih.gov/32369418
Autor:
Christine Des Rosiers, Michael A. Portman, Muhammad Nuri, Masaki Kajimoto, Isabelle Robillard-Frayne, Nancy G. Isern
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The right ventricle exposed to chronic pressure overload exhibits hypertrophy and decompensates when exposed to stress. We hypothesize that impaired ability to increase myocardial oxidative flux through pyruvate dehydrogenase leads to hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1ca2170f7bdba43b74e722b30c7d93
https://pubmed.ncbi.nlm.nih.gov/31450994
https://pubmed.ncbi.nlm.nih.gov/31450994
Autor:
Bertrand Bouchard, Julie Thompson Legault, Frédéric M. Vaz, Alexanne Cuillerier, Anik Forest, Isabelle Robillard Frayne, Christine Des Rosiers, Matthieu Ruiz, Caroline Daneault, Yan Burelle, John D. Rioux, Sonia Deschênes
Publikováno v:
JCI insight, 4(14):e123231. The American Society for Clinical Investigation
Mitochondrial dysfunction characterizes many rare and common age-associated diseases. The biochemical consequences, underlying clinical manifestations, and potential therapeutic targets, remain to be better understood. We tested the hypothesis that l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ebcbb41536c088fe672fbb5f83db27
https://doi.org/10.1172/jci.insight.123231
https://doi.org/10.1172/jci.insight.123231
Autor:
Isabelle Robillard-Frayne, Julie Hussin, Clotilde Roy, Caroline Daneault, C. Des Rosiers, S. Lejeune, N. Menghoum, Christophe Beauloye, S. Horman, Anik Forest, J. Thompson Legault, A.C. Pouleur, Luc Bertrand
Publikováno v:
Archives of Cardiovascular Diseases Supplements. 13:219
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4722b1875fd2f289202fae2a55aae26d
https://doi.org/10.1016/j.acvdsp.2021.04.174
https://doi.org/10.1016/j.acvdsp.2021.04.174