Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Isabelle R. de Luzy"'
Autor:
Isabelle R. de Luzy, Kevin C. L. Law, Niamh Moriarty, Cameron P. J. Hunt, Jennifer C. Durnall, Lachlan H. Thompson, Andras Nagy, Clare L. Parish
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Stem cell grafts present a risk of tissue overgrowth/tumors. Here, the authors utilise a human pluripotent stem cell line carrying a FailSafe suicide gene to not only ablate proliferative cells, but through timely gene activation, improve the purity
Externí odkaz:
https://doaj.org/article/ca572aff55e041bfa62cd27bc82d3238
Autor:
Christopher R. Bye, Vanessa Penna, Isabelle R. de Luzy, Carlos W. Gantner, Cameron P.J. Hunt, Lachlan H. Thompson, Clare L. Parish
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 877-890 (2019)
Summary: Human pluripotent stem cells are a valuable resource for transplantation, yet our ability to profile xenografts is largely limited to low-throughput immunohistochemical analysis by difficulties in readily isolating grafts for transcriptomic
Externí odkaz:
https://doaj.org/article/0e598a0cee5549228249d77dc5f7ee16
Autor:
Niamh Moriarty, Jessica A. Kauhausen, Chiara Pavan, Cameron P.J. Hunt, Isabelle R. de Luzy, Vanessa Penna, Charlotte M. Ermine, Lachlan H. Thompson, Clare L. Parish
Publikováno v:
J Neurosci
Midbrain dopaminergic (DA) neurons include many subtypes characterized by their location, connectivity and function. Surprisingly, mechanisms underpinning the specification of A9 neurons [responsible for motor function, including within ventral midbr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e8592e6ceb047bbe9e1d637ee892a0
https://europepmc.org/articles/PMC9233443/
https://europepmc.org/articles/PMC9233443/
Autor:
Colin W. Pouton, Jessica A. Kauhausen, Cameron P.J. Hunt, Clare L. Parish, Jonathan C. Niclis, Carlos W. Gantner, Isabelle R. de Luzy, Charlotte M. Ermine, Lachlan H. Thompson
Publikováno v:
J Neurosci
Human pluripotent stem cells (hPSCs) are a promising resource for the replacement of degenerated ventral midbrain dopaminergic (vmDA) neurons in Parkinson's disease. Despite recent advances in protocols for thein vitrogeneration of vmDA neurons, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d2f7f020b155030a912ec31be44abe
https://doi.org/10.1523/jneurosci.1160-19.2019
https://doi.org/10.1523/jneurosci.1160-19.2019
Autor:
Kevin C. L. Law, Andras Nagy, Niamh Moriarty, Isabelle R. de Luzy, Cameron P.J. Hunt, Jennifer C. Durnall, Clare L. Parish, Lachlan H. Thompson
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Despite advancements in human pluripotent stem cells (hPSCs) differentiation protocols to generate appropriate neuronal progenitors suitable for transplantation in Parkinson’s disease, resultant grafts contain low proportions of dopamine neurons. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a072f2e87db473975bbd7ba78e468eb
https://doi.org/10.1038/s41467-021-23125-9
https://doi.org/10.1038/s41467-021-23125-9
Autor:
Jessica A. Kauhausen, Niamh Moriarty, Colin W. Pouton, Carlos W. Gantner, Jonathan C. Niclis, Lachlan H. Thompson, Vanessa Penna, Christopher R. Bye, Deniz Kirik, Clare L. Parish, Isabelle R. de Luzy, Cameron P.J. Hunt, Charlotte M. Ermine
The derivation of neurotransmitter and region-specific neuronal populations from human pluripotent stem cells (PSC) provides impetus for advancing cell therapies into the clinic. At the forefront is our ability to generate ventral midbrain (VM) dopam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2d52c38b2bf6602a7ce44a8a0a21b2
Autor:
Richard J. Williams, Stephanie Franks, Vanessa Penna, Charlotte M. Ermine, Niamh Moriarty, Isabelle R. de Luzy, Clare L. Parish, Cameron P.J. Hunt, Chiara Pavan, Benjamin M. Long, Yi Wang, Carlos W. Gantner, David R. Nisbet, Lachlan H. Thompson
Publikováno v:
Advanced Functional Materials. 31:2170344
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab80d0c912e1cfea58dafac782e083af
https://doi.org/10.1002/adfm.202170344
https://doi.org/10.1002/adfm.202170344
Autor:
Isabelle R. de Luzy, Cameron P.J. Hunt, Jonathan C. Niclis, Vanessa Penna, Christopher R. Bye, Clare L. Parish, Walaa F. Alsanie, Colin W. Pouton, Lachlan H. Thompson, John M. Haynes, Jaber Firas
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Pluripotent stem cells (PSCs) are a valuable tool for interrogating development, disease modelling, drug discovery and transplantation. Despite the burgeoned capability to fate restrict human PSCs to specific neural lineages, comparative protocols fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf33786dc7be5d26d28fcc5cbebe4105
http://europepmc.org/articles/PMC5700195
http://europepmc.org/articles/PMC5700195