Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Isabelle R. Weir"'
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Randomized trials for the treatment of tuberculosis (TB) rely on a composite primary outcome to capture unfavorable treatment responses. However, variability between trials in the outcome definition and estimation methods complica
Externí odkaz:
https://doaj.org/article/342331141aa04ef1a8c6e400a9fe8aa9
Autor:
Samantha Malatesta, Isabelle R. Weir, Sarah E. Weber, Tara C. Bouton, Tara Carney, Danie Theron, Bronwyn Myers, C. Robert Horsburgh, Robin M. Warren, Karen R. Jacobson, Laura F. White
Publikováno v:
BMC Medical Research Methodology, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background The occurrence and timing of mycobacterial culture conversion is used as a proxy for tuberculosis treatment response. When researchers serially sample sputum during tuberculosis studies, contamination or missed visits leads to mis
Externí odkaz:
https://doaj.org/article/c90dabb11af54f9b953cd31967877118
Publikováno v:
Pharm Stat
In cancer randomized controlled trials, surrogate endpoints are frequently time-to-event endpoints, subject to the competing risk from the time-to-event clinical outcome. In this context, we introduce a counterfactual-based mediation analysis for a c
Autor:
Gerald S. Bloomfield, Isabelle R. Weir, Heather J. Ribaudo, Kathleen V. Fitch, Carl J. Fichtenbaum, Laura E. Moran, Roger Bedimo, Christopher de Filippi, Caryn G. Morse, Jonathan Piccini, Markella V. Zanni, Michael T. Lu, Udo Hoffmann, Steven K. Grinspoon, Pamela S. Douglas
Publikováno v:
J Acquir Immune Defic Syndr
People with HIV (PWH) are at increased risk of cardiovasvular disease (CVD) and sudden cardiac death. Previous work has suggested an association between HIV infection and electrocardiographic (ECG) abnormalities. There are limited data on the burden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16298c6d80c2eee7ea80a030179e8a6e
https://europepmc.org/articles/PMC8837824/
https://europepmc.org/articles/PMC8837824/
Autor:
Edgar T, Overton, Isabelle R, Weir, Markella V, Zanni, Stephanie, Fischinger, Rodger D, MacArthur, Judith A, Aberg, Kathleen V, Fitch, Michael, Frank, Helmut, Albrecht, Elliot, Goodenough, Frank S, Rhame, Carl J, Fichtenbaum, Gerald S, Bloomfield, Carlos, Malvestutto, Khuanchai, Supparatpinyo, Sara, McCallum, Pamela S, Douglas, Galit, Alter, Heather, Ribaudo, Steven K, Grinspoon
Publikováno v:
Journal of acquired immune deficiency syndromes (1999). 90(4)
Limited data are available regarding asymptomatic COVID-19 among people with HIV (PWH). Data on a representative subset of PWH enrolled in Randomized Trial to Prevent Vascular Events in HIV, a global clinical trial, are presented here.Randomized Tria
Publikováno v:
Biostatistics
SUMMARY In randomized controlled trials (RCTs) with time-to-event outcomes, the difference in restricted mean survival times (RMSTD) offers an absolute measure of the treatment effect on the time scale. Computation of the RMSTD relies on the choice o
Autor:
Isabelle R Weir, Sean Wasserman
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Phase IIb trials of tuberculosis therapy rely on early biomarkers of treatment effect. Despite limited predictive ability for clinical outcomes, culture conversion, the event in which an individual previously culture positive for Mycobacterium tuberc
Autor:
Isabelle R Weir, Ludovic Trinquart
Publikováno v:
Clinical Trials. 15:499-508
Background/aims Non-inferiority trials with time-to-event outcomes are becoming increasingly common. Designing non-inferiority trials is challenging, in particular, they require very large sample sizes. We hypothesized that the difference in restrict
Autor:
Yorghos Tripodis, Christian Lepage, Isabelle R Weir, Martha E. Shenton, Michael L. Alosco, Robert S. Stern, Inga K. Koerte, Julie Stamm, Alicia S. Chua, Vivian Schultz, Ofer Pasternak, Christine M. Baugh, Pawel Wrobel, Christine E. Chaisson, Nathan G. Fritts, Alexander P. Lin, Jeffrey P. Guenette, Michael J. Coleman, Brett M. Martin
Publikováno v:
Journal of Neurotrauma. 35:278-285
Thalamic atrophy has been associated with exposure to repetitive head impacts (RHI) in professional fighters. The aim of this study is to investigate whether or not age at first exposure (AFE) to RHI is associated with thalamic volume in symptomatic
Autor:
Michael J. Coleman, Robert S. Stern, Brett M. Martin, Isabelle R Weir, Michael L. Alosco, Nikos Makris, Jakob Hufschmidt, Katie Green, Christine M. Baugh, Ofer Pasternak, Inga K. Koerte, Pawel Wrobel, Marc Muehlmann, Julie Stamm, Vivian Schultz, Yorghos Tripodis, Martha E. Shenton, Christian Lepage, Nathan G. Fritts, Christine E. Chaisson, Alexander P. Lin
Publikováno v:
Brain Imaging Behav
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts. CTE has been linked to disruptions in cognition, mood, and behavior. Unfortunately, the diagnosis of CTE can only be made post-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece30e6c62fc6769214b9dfa9ce2d68f
https://europepmc.org/articles/PMC6854905/
https://europepmc.org/articles/PMC6854905/