Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Isabelle Parrilla"'
Autor:
Björn Wagner, Rolf Osterwalder, Eric A. Ertel, Lucette Doessegger, Icilio Cavero, Marion Aubert, Isabelle Parrilla
Publikováno v:
Drug Safety. 29:237-254
Background: The issue of drug-induced QT interval prolongation and torsades de pointes represents a major concern for pharmaceutical development. In this investigation, we examined the value of the isolated rabbit Purkinje fibre as an in vitro action
Autor:
Mark Rogers-Evans, Georg Wuitschik, Erick M. Carreira, Holger Fischer, Franz Schuler, Isabelle Parrilla, Björn Wagner, Klaus Müller
Publikováno v:
Journal of medicinal chemistry. 53(8)
An oxetane can trigger profound changes in aqueous solubility, lipophilicity, metabolic stability, and conformational preference when replacing commonly employed functionalities such as gem-dimethyl or carbonyl groups. The magnitude of these changes
Autor:
Björn Wagner, Andreas Buckl, Erick M. Carreira, Thierry Godel, Klaus Müller, Isabelle Parrilla, Moritz Märki, Mark Rogers-Evans, Georg Wuitschik, Maurizio Bernasconi, Josef Schneider, André Alker, Holger Fischer, Franz Schuler, W. Bernd Schweizer
Publikováno v:
Angewandte Chemie (International ed. in English). 47(24)
Autor:
Holger Fischer, Isabelle Parrilla, Krystyna Kratzat, Frank Senner, Manfred Kansy, Björn Wagner
Publikováno v:
Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf7c7c1224ef46cbcfe7694efed28c5c
https://doi.org/10.1002/9783906390437.ch24
https://doi.org/10.1002/9783906390437.ch24
Autor:
Stefanie Bendels, Manfred Kansy, Isabelle Parrilla, Alex Avdeef, Dana Lipp, Oksana Tsinman, Björn Wagner
Publikováno v:
Pharmaceutical research. 23(11)
The effect of excipients on the artificial membrane permeability (Double-Sink PAMPA) properties of eight sparingly soluble drugs was studied. Quantities of excipient were selected to match the concentrations expected in the gastrointestinal fluid und
Publikováno v:
Molecular Modeling and Prediction of Bioactivity ISBN: 9781461368571
Combinatorial and parallel chemistry and genomics in combination with high-throughput screening (HTS) are capable in increasing the number of lead compounds identified in lead discovery programs. Successful application of high-throughputtechnologies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ba10d1ac2909c7c7be8a69993b41329
https://doi.org/10.1007/978-1-4615-4141-7_28
https://doi.org/10.1007/978-1-4615-4141-7_28
Autor:
Erick M. Carreira, Thierry Godel, Mark Rogers-Evans, Moritz Märki, Isabelle Parrilla, Andreas Buckl, Franz Schuler, Josef Schneider, Björn Wagner, Georg Wuitschik, W. Bernd Schweizer, Klaus Müller, Holger Fischer, André Alker, Maurizio Bernasconi
Publikováno v:
Angewandte Chemie. 120:4522-4522
Autor:
Franz Schuler, W. Bernd Schweizer, Andreas Buckl, Holger Fischer, Klaus Müller, Mark Rogers-Evans, Thierry Godel, Erick M. Carreira, Björn Wagner, Maurizio Bernasconi, Moritz Märki, André Alker, Josef Schneider, Isabelle Parrilla, Georg Wuitschik
Publikováno v:
Angewandte Chemie International Edition. 47:4450-4450