The landscape of cancer-associated transcript fusions in adult brain tumors: a longitudinal assessment in 140 patients with cerebral gliomas and brain metastases

Autor: Philippe Metellus, Clara Camilla, Emilie Bialecki, Nathalie Beaufils, Christine Vellutini, Eric Pellegrino, Pascale Tomasini, Manmeet S. Ahluwalia, Alireza Mansouri, Isabelle Nanni, L’Houcine Ouafik

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

BackgroundOncogenic fusions of neurotrophic receptor tyrosine kinase NTRK1, NTRK2, or NTRK3 genes have been found in different types of solid tumors. The treatment of patients with TRK fusion cancer with a first-generation TRK inhibitor (such as laro

Externí odkaz: https://doaj.org/article/ed3fc3c4abd840519e77be3825438190

Extreme Gradient Boosting Tuned with Metaheuristic Algorithms for Predicting Myeloid NGS Onco-Somatic Variant Pathogenicity

Autor: Eric Pellegrino, Clara Camilla, Norman Abbou, Nathalie Beaufils, Christel Pissier, Jean Gabert, Isabelle Nanni-Metellus, L’Houcine Ouafik

Publikováno v: Bioengineering, Vol 10, Iss 7, p 753 (2023)

The advent of next-generation sequencing (NGS) technologies has revolutionized the field of bioinformatics and genomics, particularly in the area of onco-somatic genetics. NGS has provided a wealth of information about the genetic changes that underl

Externí odkaz: https://doaj.org/article/1a0d166be1784b5a9a0992983e8fc0db

Multiplexed Droplet Digital PCR Assays for the Simultaneous Screening of Major Genetic Alterations in Tumors of the Central Nervous System

Autor: Romain Appay, Frederic Fina, Doriane Barets, Catherine Gallardo, Isabelle Nanni-Metellus, Didier Scavarda, Daniel Henaff, Juline Vincent, Lise Grewis, Philippe Pourquier, Carole Colin, Dominique Figarella-Branger

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

The increased integration of molecular alterations to define tumor type or grade in central nervous system (CNS) tumor classification brings new challenges for the pathologist to make the best use of a precious limited tissue specimen for molecular s

Externí odkaz: https://doaj.org/article/4a826aecf2744791aeea007be9489131

Deep Learning Architecture Optimization with Metaheuristic Algorithms for Predicting BRCA1/BRCA2 Pathogenicity NGS Analysis

Autor: Eric Pellegrino, Theo Brunet, Christel Pissier, Clara Camilla, Norman Abbou, Nathalie Beaufils, Isabelle Nanni-Metellus, Philippe Métellus, L’Houcine Ouafik

Publikováno v: BioMedInformatics
BioMedInformatics, 2022, 2 (2), pp.244-267. ⟨10.3390/biomedinformatics2020016⟩
BioMedInformatics; Volume 2; Issue 2; Pages: 244-267

BRCA1 and BRCA2 are genes with tumor suppressor activity, and they are involved ina considerable number of biological processes allowing the regulation of the cellreplication cycle. A mutation in one of these two genes has a significant probability o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8892fcdb02ae5995ca875aeae713cbb4
https://doi.org/10.3390/biomedinformatics2020016

Adrenomedullin Secreted by Melanoma Cells Promotes Melanoma Tumor Growth through Angiogenesis and Lymphangiogenesis

Autor: Zohra Benyahia, Caroline Gaudy-Marqueste, Caroline Berenguer-Daizé, Norhimane Chabane, Nadège Dussault, Mylène Cayol, Christine Vellutini, Amina Djemli, Isabelle Nanni, Nathalie Beaufils, Kamel Mabrouk, Jean-Jacques Grob, L’Houcine Ouafik

Publikováno v: Cancers; Volume 14; Issue 23; Pages: 5909
Cancers
Cancers, 2022, 14 (23), pp.5909. ⟨10.3390/cancers14235909⟩

Introduction: Metastatic melanoma is an aggressive tumor and can constitute a real therapeutic challenge despite the significant progress achieved with targeted therapies and immunotherapies, thus highlighting the need for the identification of new t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdf9cb8a63bf017ba5aaf77db454b9a
https://pubmed.ncbi.nlm.nih.gov/36497391