Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Isabelle Marois"'
Autor:
Maïlyn Yates, Isabelle Marois, Edlie St-Hilaire, Daryl A Ronato, Billel Djerir, Chloé Brochu, Théo Morin, Ian Hammond-Martel, Sari Gezzar-Dandashi, Lisa Casimir, Elliot Drobetsky, Laurent Cappadocia, Jean-Yves Masson, Hugo Wurtele, Alexandre Maréchal
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002552 (2024)
Impediments in replication fork progression cause genomic instability, mutagenesis, and severe pathologies. At stalled forks, RPA-coated single-stranded DNA (ssDNA) activates the ATR kinase and directs fork remodeling, 2 key early events of the repli
Externí odkaz:
https://doaj.org/article/7a96143210c043db9c56e93cd5ee4106
Autor:
Isabelle Meunier, Olivier Morisseau, Émilie Garneau, Isabelle Marois, Alexandre Cloutier, Martin V Richter
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138055 (2015)
Despite a relatively low fatality rate, the 2009 H1N1 pandemic virus differed from other seasonal viruses in that it caused mortality and severe pneumonia in the young and middle-aged population (18-59 years old). The mechanisms underlying this incre
Externí odkaz:
https://doaj.org/article/bd29aa0ad0b14e919e743d2070a821e6
Autor:
Isabelle Marois, Alexandre Cloutier, Isabelle Meunier, Hana M Weingartl, André M Cantin, Martin V Richter
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110631 (2014)
Antivirals that are currently used to treat influenza virus infections target components of the virus which can mutate rapidly. Consequently, there has been an increase in the number of resistant strains to one or many antivirals in recent years. Her
Externí odkaz:
https://doaj.org/article/047221c8a38541ca9d710bd042680926
Publikováno v:
Poster Presentations.
Background Innate lymphoid cells (ILC) are immune cells of the lymphoid lineage not expressing specific antigen receptors.They are classified into three subsets: ILC1 (including Natural Killer (NK) cells and ILC1) secrete IFN-γ and TNF-α; ILC2 secr
Publikováno v:
The FASEB Journal. 29:973-987
The clinical benefits of oseltamivir (Tamiflu) are well established, but the effects of antiviral treatment on the immune response are poorly understood. By use of flow cytometric analyses and the mouse model, we thoroughly investigated the impact of
Publikováno v:
Journal of Leukocyte Biology. 92:107-121
Infectious dose of influenza determines inflammatory, innate, and adaptive CD8+ T cell responses, and modulates central and effector protective immunity to heterologous infection. Factors from the virus and the host contribute to influenza virus path
Autor:
Martin V. Richter, Frédéric Leduc, Mélina Arguin, Olivier Simard, Marc-André Brazeau, Marie-Chantal Grégoire, Geneviève Acteau, Guylain Boissonneault, Isabelle Marois
Publikováno v:
Journal of Visualized Experiments.
The differentiation of mouse spermatids is one critical process for the production of a functional male gamete with an intact genome to be transmitted to the next generation. So far, molecular studies of this morphological transition have been hamper
Autor:
Frédéric Leduc, Marc-André Brazeau, Olivier Simard, Martin V. Richter, Mélina Arguin, Guylain Boissonneault, Isabelle Marois, Marie-Chantal Grégoire
Publikováno v:
Human Mutation.
Transient DNA breaks and evidence of DNA damage response have recently been reported during the chromatin remodeling process in haploid spermatids, creating a potential window of enhanced genetic instability. We used flow cytometry to achieve separat
Autor:
Éloïc Colombo, Eric Marsault, Émilie Gravel, Alexandre Cloutier, Catherine Verreault, Antoine Désilets, A. Beaulieu, Martin V. Richter, Richard Leduc, Isabelle Marois
Publikováno v:
Journal of Virology
Influenza viruses do not encode any proteases and must rely on host proteases for the proteolytic activation of their surface hemagglutinin proteins in order to fuse with the infected host cells. Recent progress in the understanding of human protease
Autor:
Alexandre Cloutier, Diane Cloutier, Catherine Verreault, Isabelle Marois, Martin V. Richter, André M. Cantin
Publikováno v:
The Journal of infectious diseases. 205(4)
BACKGROUND Growing evidence indicates that influenza pathogenicity relates to altered immune responses and hypercytokinemia. Therefore, dampening the excessive inflammatory response induced after infection might reduce influenza morbidity and mortali