Zobrazeno 1 - 10 of 62 pro vyhledávání: '"Isabelle M. L. Billas"'
1
Akademický článek
LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice
Autor: Qingshuang Cai, Rajesh Sahu, Vanessa Ueberschlag-Pitiot, Sirine Souali-Crespo, Céline Charvet, Ilyes Silem, Félicie Cottard, Tao Ye, Fatima Taleb, Eric Metzger, Roland Schuele, Isabelle M. L. Billas, Gilles Laverny, Daniel Metzger, Delphine Duteil
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Synthetic glucocorticoids (GC), such as dexamethasone, are extensively used to treat chronic inflammation and autoimmune disorders. However, long-term treatments are limited by various side effects, including muscle atrophy. GC activities ar
Externí odkaz: https://doaj.org/article/e89b08569ca248679acaa8a0ab04d2df
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2
Akademický článek
A novel nuclear receptor subfamily enlightens the origin of heterodimerization
Autor: Brice Beinsteiner, Gabriel V. Markov, Maxime Bourguet, Alastair G. McEwen, Stéphane Erb, Abdul Kareem Mohideen Patel, Fatima Z. El Khaloufi El Khaddar, Claire Lecroisey, Guillaume Holzer, Karim Essabri, Isabelle Hazemann, Ali Hamiche, Sarah Cianférani, Dino Moras, Vincent Laudet, Isabelle M. L. Billas
Publikováno v: BMC Biology, Vol 20, Iss 1, Pp 1-19 (2022)
Abstract Background Nuclear receptors are transcription factors of central importance in human biology and associated diseases. Much of the knowledge related to their major functions, such as ligand and DNA binding or dimerization, derives from funct
Externí odkaz: https://doaj.org/article/a92389b629514a4e8a6968a1a1cd396d
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3
Akademický článek
Structural insights into the HNF4 biology
Autor: Brice Beinsteiner, Isabelle M. L. Billas, Dino Moras
Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)
Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor (NR) family that is expressed in liver, kidney, intestine and pancreas. It is a master regulator of liver-specific gene expression, in particular thos
Externí odkaz: https://doaj.org/article/010d8580355b40078ae4111df27f9fe9
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4
Akademický článek
Importance of the Sequence-Directed DNA Shape for Specific Binding Site Recognition by the Estrogen-Related Receptor
Autor: Kareem Mohideen-Abdul, Karima Tazibt, Maxime Bourguet, Isabelle Hazemann, Isabelle Lebars, Maria Takacs, Sarah Cianférani, Bruno P. Klaholz, Dino Moras, Isabelle M. L. Billas
Publikováno v: Frontiers in Endocrinology, Vol 8 (2017)
Most nuclear receptors (NRs) bind DNA as dimers, either as hetero- or as homodimers on DNA sequences organized as two half-sites with specific orientation and spacing. The dimerization of NRs on their cognate response elements (REs) involves specific
Externí odkaz: https://doaj.org/article/19a2cb3e9d3b417cbd1630f4b448a509
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6
Nonsteroidal ecdysone receptor agonists use a water channel for binding to the ecdysone receptor complex EcR/USP
Autor: Dino Moras, Yoshiaki Nakagawa, Alastair G. McEwen, Isabelle M. L. Billas, Kotaro Mori, Christopher Browning, Taiyo Yokoi
Publikováno v: 'Journal of Pesticide Science ', vol: 46, pages: 88-100 (2021)
J Pestic Sci
Journal of Pesticide Science
Journal of Pesticide Science, 2021, 46 (1), pp.88-100. ⟨10.1584/jpestics.D20-095⟩
The ecdysone receptor (EcR) possesses the remarkable capacity to adapt structurally to different types of ligands. EcR binds ecdysteroids, including 20-hydroxyecdysone (20E), as well as nonsteroidal synthetic agonists such as insecticidal dibenzoylhy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2436abec253666a1be837d7331aeb13
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:58004
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7
A novel nuclear receptor subfamily enlightens the origin of heterodimerization
Autor: Brice Beinsteiner, Gabriel V. Markov, Maxime Bourguet, Alastair G. McEwen, Stéphane Erb, Abdul Kareem Mohideen Patel, Fatima Z. El Khaloufi El Khaddar, Claire Lecroisey, Guillaume Holzer, Karim Essabri, Isabelle Hazemann, Ali Hamiche, Sarah Cianférani, Dino Moras, Vincent Laudet, Isabelle M. L. Billas
Publikováno v: BMC Biology
BMC Biology, 2022, 20 (1), pp.217. ⟨10.1186/s12915-022-01413-0⟩
Background Nuclear receptors are transcription factors of central importance in human biology and associated diseases. Much of the knowledge related to their major functions, such as ligand and DNA binding or dimerization, derives from functional stu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ac7fd0c5fff044f6166b8561d2fba0
https://pubmed.ncbi.nlm.nih.gov/36199108
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8
Myod1 and GR coordinate myofiber-specific transcriptional enhancers
Autor: Vanessa Ueberschlag-Pitiot, Gilles Laverny, Tom Sexton, Maxime Parisotto, D. Rovito, Kamar Ghaibour, Vanessa Dacleu-Siewe, Delphine Duteil, Khalil Ben Rayana, Isabelle M. L. Billas, Scott A. Jelinsky, Anna-Isavella Rerra, Nezih Karasu, Bruno P. Klaholz, Daniel Metzger, Shilpy Joshi, Arnaud Ferry
Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2021, 49 (8), pp.4472-4492. ⟨10.1093/nar/gkab226⟩
Nucleic Acids Res
Nucleic Acids Research, 2021, 49 (8), pp.4472-4492. ⟨10.1093/nar/gkab226⟩
Skeletal muscle is a dynamic tissue the size of which can be remodeled through the concerted actions of various cues. Here, we investigated the skeletal muscle transcriptional program and identified key tissue-specific regulatory genetic elements. Ou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffef75199065ddbba30f9986cb94094d
https://hal.sorbonne-universite.fr/hal-03251776
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9
A structural signature motif enlightens the origin and diversification of nuclear receptors
Autor: Stéphane Erb, Vincent Laudet, Yassmine Chebaro, Dino Moras, Gabriel V. Markov, Alastair G. McEwen, Isabelle M. L. Billas, Brice Beinsteiner, Sarah Cianférani
Publikováno v: PLoS Genetics
PLoS Genetics, Vol 17, Iss 4, p e1009492 (2021)
PLoS Genetics, Public Library of Science, 2021, 17 (4), pp.e1009492. ⟨10.1371/journal.pgen.1009492⟩
Nuclear receptors are ligand-activated transcription factors that modulate gene regulatory networks from embryonic development to adult physiology and thus represent major targets for clinical interventions in many diseases. Most nuclear receptors fu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760b56ff558d1132b159803288c7ca74
http://europepmc.org/articles/PMC8092661
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