Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Isabelle M. Capell-Hattam"'
Autor:
Lydia Qian, Nicola A. Scott, Isabelle M. Capell-Hattam, Eliza A. Draper, Nicole M. Fenton, Winnie Luu, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100362- (2023)
Cholesterol biosynthesis is a highly regulated pathway, with over 20 enzymes controlled at the transcriptional and posttranslational levels. While some enzymes remain stable, increased sterol levels can trigger degradation of several synthesis enzyme
Externí odkaz:
https://doaj.org/article/c248162951394c64a07c42242ea8d86c
Autor:
Isabelle M. Capell-Hattam, Nicole M. Fenton, Hudson W. Coates, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 12, Pp 100295- (2022)
The enzymatic pathway of cholesterol biosynthesis has been well characterized. However, there remain several potential interacting proteins that may play ancillary roles in the regulation of cholesterol production. Here, we identified ERG28 (chromoso
Externí odkaz:
https://doaj.org/article/ed19bf38775a4237b40c5078c46e0707
Autor:
Hudson W Coates, Isabelle M Capell-Hattam, Ellen M Olzomer, Ximing Du, Rhonda Farrell, Hongyuan Yang, Frances L Byrne, Andrew J Brown
Publikováno v:
eLife. 12
Cholesterol synthesis is both energy- and oxygen-intensive, yet relatively little is known of the regulatory effects of hypoxia on pathway enzymes. We previously showed that the rate-limiting and first oxygen-dependent enzyme of the committed cholest
Autor:
Isabelle M. Capell-Hattam, Anika V. Prabhu, Andrew J. Brown, Lydia Qian, Gene Hart-Smith, Laura J. Sharpe
Publikováno v:
J Biol Chem
Cholesterol synthesis is a tightly regulated process, both transcriptionally and post-translationally. Transcriptional control of cholesterol synthesis is relatively well-understood. However, of the ∼20 enzymes in cholesterol biosynthesis, post-tra
Autor:
Samuel J. Gullo, Nicola A. Scott, Winnie Luu, Andrew J. Brown, Isabelle M. Capell-Hattam, Laura J. Sharpe
Publikováno v:
Biochemical Journal
Cholesterol synthesis is a tightly controlled pathway, with over 20 enzymes involved. Each of these enzymes can be distinctly regulated, helping to fine-tune the production of cholesterol and its functional intermediates. Several enzymes are degraded
Autor:
Isabelle M. Capell-Hattam, Nicole M. Fenton, Hudson W. Coates, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of lipid research. 63(12)
The enzymatic pathway of cholesterol biosynthesis has been well characterized. However, there remain several potential interacting proteins that may play ancillary roles in the regulation of cholesterol production. Here, we identified ERG28 (chromoso
Publikováno v:
Current biology : CB. 30(15)
Although cholesterol is considered a vital lipid for animals, not all animals can make cholesterol. A new study employing that celebrated elegant worm, Caenorhabditis elegans, investigates mechanisms that evolved in a sterol auxotroph to enable survi
Publikováno v:
The Journal of Biological Chemistry
Squalene monooxygenase (SM, also known as squalene epoxidase) is a rate-limiting enzyme of cholesterol synthesis that converts squalene to monooxidosqualene and is oncogenic in numerous cancer types. SM is subject to feedback regulation via cholester
Publikováno v:
Annual Review of Pharmacology and Toxicology. 56:447-467
Oxysterols have long been known for their important role in cholesterol homeostasis, where they are involved in both transcriptional and posttranscriptional mechanisms for controlling cholesterol levels. However, they are increasingly associated with