Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Isabelle M Capell-Hattam"'
Autor:
Hudson W Coates, Isabelle M Capell-Hattam, Ellen M Olzomer, Ximing Du, Rhonda Farrell, Hongyuan Yang, Frances L Byrne, Andrew J Brown
Publikováno v:
eLife, Vol 12 (2023)
Cholesterol synthesis is both energy- and oxygen-intensive, yet relatively little is known of the regulatory effects of hypoxia on pathway enzymes. We previously showed that the rate-limiting and first oxygen-dependent enzyme of the committed cholest
Externí odkaz:
https://doaj.org/article/3f53fc512fcc4b44b302c034457a3da2
Autor:
Lydia Qian, Nicola A. Scott, Isabelle M. Capell-Hattam, Eliza A. Draper, Nicole M. Fenton, Winnie Luu, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of Lipid Research. 64:100362
Autor:
Isabelle M. Capell-Hattam, Anika V. Prabhu, Andrew J. Brown, Lydia Qian, Gene Hart-Smith, Laura J. Sharpe
Publikováno v:
J Biol Chem
Cholesterol synthesis is a tightly regulated process, both transcriptionally and post-translationally. Transcriptional control of cholesterol synthesis is relatively well-understood. However, of the ∼20 enzymes in cholesterol biosynthesis, post-tra
Autor:
Samuel J. Gullo, Nicola A. Scott, Winnie Luu, Andrew J. Brown, Isabelle M. Capell-Hattam, Laura J. Sharpe
Publikováno v:
Biochemical Journal
Cholesterol synthesis is a tightly controlled pathway, with over 20 enzymes involved. Each of these enzymes can be distinctly regulated, helping to fine-tune the production of cholesterol and its functional intermediates. Several enzymes are degraded
Autor:
Isabelle M. Capell-Hattam, Nicole M. Fenton, Hudson W. Coates, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of lipid research. 63(12)
The enzymatic pathway of cholesterol biosynthesis has been well characterized. However, there remain several potential interacting proteins that may play ancillary roles in the regulation of cholesterol production. Here, we identified ERG28 (chromoso
Publikováno v:
Current biology : CB. 30(15)
Although cholesterol is considered a vital lipid for animals, not all animals can make cholesterol. A new study employing that celebrated elegant worm, Caenorhabditis elegans, investigates mechanisms that evolved in a sterol auxotroph to enable survi
Publikováno v:
The Journal of Biological Chemistry
Squalene monooxygenase (SM, also known as squalene epoxidase) is a rate-limiting enzyme of cholesterol synthesis that converts squalene to monooxidosqualene and is oncogenic in numerous cancer types. SM is subject to feedback regulation via cholester
Publikováno v:
Annual Review of Pharmacology and Toxicology. 56:447-467
Oxysterols have long been known for their important role in cholesterol homeostasis, where they are involved in both transcriptional and posttranscriptional mechanisms for controlling cholesterol levels. However, they are increasingly associated with
Autor:
Laura J. Sharpe, Samuel J. Gullo, Andrew J. Brown, Nicola A. Scott, Isabelle M. Capell-Hattam, Winnie Luu
Publikováno v:
The FASEB Journal. 34:1-1
Cholesterol synthesis is a tightly controlled pathway, with over 20 enzymes involved. Each of these enzymes can be distinctly regulated, helping to fine-tune the production of cholesterol and its functional intermediates. Several enzymes are degraded