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Autor:
Eve Damiens, Cécile Debitus, Michèle Guyot, Laurent Meijer, Isabelle Le Saout, Mohammad Samadi, Sophie Leclerc, Ali Loukaci
Publikováno v:
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2001, 9, pp.3049-3054
Bioorganic and Medicinal Chemistry, Elsevier, 2001, 9, pp.3049-3054
The dual specificity CDC25 phosphatases dephosphorylate two inhibitory phospho-amino acids of cyclin-dependent kinases, a major family of cell cycle regulators. CDC25 inhibitors constitute new anti-mitotic agents with potential anticancer activity. W