Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Isabelle Lavenir"'
Autor:
Manuel Schweighauser, Alexey G. Murzin, Jennifer Macdonald, Isabelle Lavenir, R. Anthony Crowther, Sjors H.W. Scheres, Michel Goedert
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-11 (2023)
Abstract Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous inclusions made of human mutant four-repeat tau. Here we used electron cryo-microscopy (cryo-
Externí odkaz:
https://doaj.org/article/43edd87f5ecc46a6b3d9100ebbe7d73f
Autor:
Jennifer A. Macdonald, John L. Chen, Masami Masuda-Suzukake, Manuel Schweighauser, Zane Jaunmuktane, Thomas Warner, Janice L. Holton, Annabelle Grossman, Richard Berks, Isabelle Lavenir, Michel Goedert
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83). The same was the case when cereb
Externí odkaz:
https://doaj.org/article/bb04ab8adf9d41ed8dc3cbb1e5c3ee4c
Autor:
Isabelle Lavenir, Daniela Passarella, Masami Masuda-Suzukake, Annabelle Curry, Janice L. Holton, Bernardino Ghetti, Michel Goedert
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract Synucleinopathies [Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA)] share filamentous α-synuclein assemblies in nerve cells and glial cells. We compared the abilities of brain extracts from MSA
Externí odkaz:
https://doaj.org/article/f2e2357037754171bea60e9a5183766a
Autor:
Jennifer A. Macdonald, Iraad F. Bronner, Lesley Drynan, Juan Fan, Annabelle Curry, Graham Fraser, Isabelle Lavenir, Michel Goedert
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract A pathological pathway leading from soluble monomeric to insoluble filamentous Tau is characteristic of many human neurodegenerative diseases, which also exhibit dysfunction and death of brain cells. However, it is unknown how the assembly o
Externí odkaz:
https://doaj.org/article/b5e78336638247b6b7a93dfe965c6c2a
Autor:
Yang Yang, Wenjuan Zhang, Alexey G. Murzin, Manuel Schweighauser, Melissa Huang, Sofia Lövestam, Sew Y. Peak-Chew, Takashi Saito, Takaomi C. Saido, Jennifer Macdonald, Isabelle Lavenir, Bernardino Ghetti, Caroline Graff, Amit Kumar, Agneta Nordberg, Michel Goedert, Sjors H. W. Scheres
Publikováno v:
Acta neuropathologica.
Funder: Biotechnology and Biological Sciences Research Council; doi: http://dx.doi.org/10.13039/501100000268
The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited
The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited
Autor:
Masami Masuda-Suzukake, Michel Goedert, Daniela Passarella, Isabelle Lavenir, Dennis W. Dickson, Sophie A. Morgan, X. Bernardino Ghetti, Michael DeTure, Juan Fan
Publikováno v:
The Journal of Biological Chemistry
Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient cent
Autor:
Janice L. Holton, Zane Jaunmuktane, John L Chen, Thomas T. Warner, Masami Masuda-Suzukake, Michel Goedert, Annabelle Grossman, Richard Berks, Manuel Schweighauser, Isabelle Lavenir, Jennifer A. Macdonald
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83). The same was the case when cerebellar ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86869e0e4249259b4e469687b4f3482
https://www.repository.cam.ac.uk/handle/1810/331029
https://www.repository.cam.ac.uk/handle/1810/331029
Autor:
Melissa Huang, Jennifer Macdonald, Isabelle Lavenir, Renren Chen, Molly Craxton, Elizabeth Slavik-Smith, Stephen W. Davies, Michel Goedert
Publikováno v:
eneuro. 9:ENEURO.0247-22.2022
Alzheimer’s Disease (AD) is characterized by the pathologic assembly of amyloid β (Aβ) peptide, which deposits into extracellular plaques, and tau, which accumulates in intraneuronal inclusions. To investigate the link between Aβ and tau patholo
Autor:
Alexey G. Murzin, Wenjuan Zhang, Melissa Huang, Kathy L. Newell, Isabelle Lavenir, Ellen Gelpi, Bernardino Ghetti, Sofia Lövestam, Michel Goedert, Holly J. Garringer, Sew Y. Peak-Chew, Abhay Kotecha, Benjamin Falcon, Yang Yang, Jennifer A. Macdonald, Gabor G. Kovacs, Sjors H.W. Scheres, Manuel Schweighauser, Diana Arseni, Ruben Vidal
Publikováno v:
Science
Filament assembly of amyloid-β peptides ending at residue 42 (Aβ42) is a central event in Alzheimer’s disease. We report the cryo-EM structures of Aβ42 filaments from brain. Two structurally related S-shaped protofilament folds give rise to two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a48e57feff85f04c66cbb2d57cbd196
https://doi.org/10.1101/2021.10.19.464936
https://doi.org/10.1101/2021.10.19.464936
Autor:
Annabelle Curry, Michel Goedert, Bernardino Ghetti, Janice L. Holton, Masami Masuda-Suzukake, Isabelle Lavenir, Daniela Passarella
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-11 (2019)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Synucleinopathies [Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA)] share filamentous α-synuclein assemblies in nerve cells and glial cells. We compared the abilities of brain extracts from MSA and PD pa