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Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes
Autor:
Christina P. Martins, Lee A. New, Erin C. O’Connor, Dana M. Previte, Kasey R. Cargill, Isabelle L. Tse, Sunder Sims- Lucas, Jon D. Piganelli
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In Type 1 Diabetes (T1D), CD4+ T cells initiate autoimmune attack of pancreatic islet β cells. Importantly, bioenergetic programs dictate T cell function, with specific pathways required for progression through the T cell lifecycle. During activatio
Externí odkaz:
https://doaj.org/article/d2aeee18bae74b039de8bfa66700b055
