Výsledky vyhledávání - "Isabelle Léna"

Akademický článek

The Intracellular Na+/H+ Exchanger NHE7 Effects a Na+-Coupled, but Not K+-Coupled Proton-Loading Mechanism in Endocytosis

Autor: Nina Milosavljevic, Michaël Monet, Isabelle Léna, Frédéric Brau, Sandra Lacas-Gervais, Sylvain Feliciangeli, Laurent Counillon, Mallorie Poët

Publikováno v: Cell Reports, Vol 7, Iss 3, Pp 689-696 (2014)

Vesicular H+-ATPases and ClC-chloride transporters are described to acidify intracellular compartments, which also express the highly conserved Na+/H+ exchangers NHE6, NHE7, and NHE9. Mutations of these exchangers cause autism-spectrum disorders and

Externí odkaz: https://doaj.org/article/5ed5e3d9e4a14ff6887a40dbb4eb51a3

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Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and NaV1.1 channels

Autor: Mathieu Desroches, Martin Krupa, Paolo Scalmani, Alexandre Loucif, Sandrine Cestèle, Lara Pizzamiglio, Louisiane Lemaire, Massimo Mantegazza, Isabelle Léna, Sarah Zerimech, Fabrice Duprat, Marion Ayrault, Oana Chever

Publikováno v: The Journal of clinical investigation
The Journal of clinical investigation, 2021, 131 (21), ⟨10.1172/JCI142203⟩
The Journal of clinical investigation, 2021, 131 (21), pp.e142203. ⟨10.1172/JCI142203⟩
The Journal of Clinical Investigation

International audience; Spreading depolarizations (SDs) are involved in migraine, epilepsy, stroke, traumatic brain injury, and subarachnoid hemorrhage. However, the cellular origin and specific differential mechanisms are not clear. Increased glutam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfb93071dd5e127c1f4b08d57caefd8
https://hal.archives-ouvertes.fr/hal-03411366/document

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NaV1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age

Autor: Isabelle Léna, Massimo Mantegazza

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-49392-7⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)

Mutations of the SCN2A gene, encoding the voltage gated sodium channel NaV1.2, have been associated to a wide spectrum of epileptic disorders ranging from benign familial neonatal-infantile seizures to early onset epileptic encephalopathies such as O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba089c9e0a8415e467bf35fbe86f1e6
https://hal.archives-ouvertes.fr/hal-02560537

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Molecular and electrophysiological changes in the prefrontal cortex–amygdala–dorsal periaqueductal grey pathway during persistent pain state and fear-conditioned analgesia

Autor: Carine Cleren, Linda Nilsson-Todd, René Garcia, David P. Finn, Isabelle Léna, Ryan K. Butler

Publikováno v: Physiology & Behavior. 104:1075-1081

Fear-conditioned analgesia (FCA) is the reduction in pain responding which is expressed upon re-exposure to a context previously paired with an aversive stimulus. Projections along the prefrontal cortex (PFC)–amygdala–dorsal periaqueductal grey (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f509903cc01a1359ee3cacac268cdabd
https://doi.org/10.1016/j.physbeh.2011.05.028

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Mechanisms underlying a life-threatening skeletal muscle Na+channel disorder

Autor: Isabelle Léna, Pierre Landrieu, Laurence Lion-François, Dina Simkin, Saïd Bendahhou, Damien Sternberg, Bertrand Fontaine

Publikováno v: The Journal of Physiology. 589:3115-3124

Myotonia is an intrinsic muscular disorder caused by muscle fibre hyperexcitability, which produces a prolonged time for relaxation after voluntary muscle contraction or internal mechanical stimulation. Missense mutations in skeletal muscle genes enc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38ecf18e3398476dc641b3e3d9166d8c
https://doi.org/10.1113/jphysiol.2011.207977

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Alterations in prefrontal glutamatergic and noradrenergic systems following MK-801 administration in rats prenatally exposed to methylazoxymethanol at gestational day 17

Autor: René Garcia, Marie-Odile Krebs, Aline Chessel, Gwenaëlle Le Pen, Isabelle Léna

Publikováno v: Psychopharmacology. 192:373-383

Prenatal methylazoxymethanol (MAM) administration at gestational day 17 has been shown to induce in adult rats schizophrenia-like behaviours as well as morphological and/or functional abnormalities in structures such as the hippocampus, medial prefro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667ade525d65f605eeb9e110342f7d54
https://doi.org/10.1007/s00213-007-0719-x

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Functional characterization of Na+/H+ exchangers of intracellular compartments using proton-killing selection to express them at the plasma membrane

Autor: Nina, Milosavljevic, Mallorie, Poët, Michael, Monet, Eléonore, Birgy-Barelli, Isabelle, Léna, Laurent, Counillon

Publikováno v: Journal of visualized experiments : JoVE. (97)

Endosomal acidification is critical for a wide range of processes, such as protein recycling and degradation, receptor desensitization, and neurotransmitter loading in synaptic vesicles. This acidification is described to be mediated by proton ATPase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca9f3261ea2a7c6111a852383394f401
https://pubmed.ncbi.nlm.nih.gov/25867523

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Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

Autor: Laurent Counillon, Eléonore Birgy-Barelli, Mallorie Poët, Isabelle Léna, Nina Milosavljevic, Michael Monet

Publikováno v: Journal of Visualized Experiments.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408e2aa1ada2814acffbdd46fcf2dc6a
https://doi.org/10.3791/52453

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Prefrontal infusion of PD098059 immediately after fear extinction training blocks extinction-associated prefrontal synaptic plasticity and decreases prefrontal ERK2 phosphorylation

Autor: René Garcia, Isabelle Léna, Robert Marsault, Sandrine Hugues, Aline Chessel

Publikováno v: Synapse. 60:280-287

A previous study has demonstrated that disruption of fear extinction-induced long-term potentiation (LTP) in the medial prefrontal cortex (mPFC) is associated with the return of fear responding. Given that immediate posttraining infusion of PD098059,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9239d9e0435053add72c19784bba4f67
https://doi.org/10.1002/syn.20291

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