Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Isabelle Kuhn"'
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Akademický článek
Non-specific interactions of antibody-oligonucleotide conjugates with living cells
Autor: Victor Lehot, Isabelle Kuhn, Marc Nothisen, Stéphane Erb, Sergii Kolodych, Sarah Cianférani, Guilhem Chaubet, Alain Wagner
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Antibody-Oligonucleotide Conjugates (AOCs) represent an emerging class of functionalized antibodies that have already been used in a wide variety of applications. While the impact of dye and drug conjugation on antibodies’ ability to bind
Externí odkaz: https://doaj.org/article/a5fbede99bbf44099b9275daa73200ad
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2
Akademický článek
Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.
Autor: Pascal F Egea, Hélène Muller-Steffner, Isabelle Kuhn, Céline Cakir-Kiefer, Norman J Oppenheimer, Robert M Stroud, Esther Kellenberger, Francis Schuber
Publikováno v: PLoS ONE, Vol 7, Iss 4, p e34918 (2012)
Bovine CD38/NAD(+)glycohydrolase (bCD38) catalyses the hydrolysis of NAD(+) into nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose (cADPR). We solved the crystal structures of the mono N-glycosylated forms of the ecto-domain of bCD38
Externí odkaz: https://doaj.org/article/c292c8f9ebde4e57b19de2aa4ca4f8f3
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3
Antischistosomal Evaluation of Stem Bark's Extract and Chemical Constituents from Anonidium mannii against Schistosoma mansoni
Autor: DiderotTchamo Noungoue, JosetteLinda Toussi Matchi, Guilhem Chaubet, Jérôme Boissier, Isabelle Kuhn, JeanClaude Tchouankeu, Marc Nothisen, Sylvain Ursuegui, SilvèreAugustin Ngouela, Alain Wagner
Publikováno v: Pharmacognosy Magazine (0973-1296) (Wolters Kluwer Medknow Publications), 2021-10, Vol. 17, N. 76, P. 752-758
Context Anonidium mannii (Annonaceae) has been traditionally used in Africa to treat stomach aches, schistosomiasis, and many other illnesses. However, few phytochemical study and no investigation on schistosomiasis have been conducted on this specie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ae1148a376c2a4992ff32771eaa9f5
https://archimer.ifremer.fr/doc/00772/88354/
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4
Non-specific interactions of antibody-oligonucleotide conjugates with living cells
Autor: Marc Nothisen, Alain Wagner, Isabelle Kuhn, Sergii Kolodych, Sarah Cianférani, Victor Lehot, Stéphane Erb, Guilhem Chaubet
Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-85352-w⟩
Antibody-Oligonucleotide Conjugates (AOCs) represent an emerging class of functionalized antibodies that have already been used in a wide variety of applications. While the impact of dye and drug conjugation on antibodies’ ability to bind their tar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3a1f288af2ff3d28a6fbf86cffa225
https://doi.org/10.1038/s41598-021-85352-w
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5
Manniindole, an indole derivative from the roots of Anonidium mannii and combined antischistosomal and enzymatic activities
Autor: Josette Linda Toussi Matchi, Marc Nothisen, Jean Claude Tchouankeu, Jérôme Boissier, Sylvain Ursuegui, Guilhem Chaubet, Silvère Ngouela, Delphine Garnier, Diderot T. Noungoue, Isabelle Kuhn, Alain Wagner
Publikováno v: Natural Product Research
Natural Product Research, Taylor & Francis, In press, ⟨10.1080/14786419.2020.1824227⟩
Natural Product Research, Taylor & Francis, 2020, pp.1-9. ⟨10.1080/14786419.2020.1824227⟩
Natural Product Research (1478-6419) (Taylor & Francis Ltd), 2021-12, Vol. 35, N. 24, P. 5665-5673
International audience; A new alkaloid, manniindole 1, together with four known compounds: aristolactam AII 2, aristolactam BII 3, piperolactam D 4 and polycarpol 5 were isolated from the crude extract EtOHH2O (8:2) of the roots of Anonidium mannii b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87574a5438ef0c378d46a04782b6d564
https://hal.archives-ouvertes.fr/hal-02996085/file/Toussi-2020-NatProdRes-Manniidole-MANUSCRIT.pdf
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7
Das Mainzer Deutschhaus: Geschichte, Gegenwart und Zukunft eines Ortes mit symbolischer Strahlkraft
Autor: Isabelle Kuhn
Publikováno v: Die politische Architektur deutscher Parlamente ISBN: 9783658293307
Das historische Deutschhaus beherbergt seit 1951 den Rheinland-Pfalzischen Landtag – Zeit, sich das geschichtstrachtige Gebaude einmal genauer anzuschauen. Als es vor fast 300 Jahren zunachst als Herrschaftssitz erbaut wurde, deutete noch nichts au
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af0bb454a1b857e17164c9bf5bfc31bd
https://doi.org/10.1007/978-3-658-29331-4_14
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8
On the use of DNA as a linker in antibody-drug conjugates: synthesis, stability and in vitro potency
Autor: Oleksandr Koniev, Sylvain Ursuegui, Igor Dovgan, Marc Nothisen, Manon Ripoll, Sergii Kolodych, Isabelle Kuhn, Alain Wagner, Sarah Cianférani, Alexandre Hentz, Anthony Ehkirch, Victor Lehot
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-64518-y⟩
Here we present the synthesis and evaluation of antibody-drug conjugates (ADCs), for which antibody and drug are non-covalently connected using complementary DNA linkers. These ADCs are composed of trastuzumab, an antibody targeting HER2 receptors ov
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a76953282b6adc6deb41770f2169ee
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9
Efficient Inhibition of Sm NACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal
Autor: Davide Botta, Hélène Muller-Steffner, Paul Osswald, Isabelle Kuhn, Sylvain A. Jacques, Frances E. Lund, Michael D. Schultz, Clarisse Maechling, Esther Kellenberger
Publikováno v: ACS Chemical Biology
ACS Chemical Biology, American Chemical Society, 2017, 12 (7), pp.1787-1795. ⟨10.1021/acschembio.7b00186⟩
SmNACE is a NAD catabolizing enzyme expressed on the outer tegument of S. mansoni, a human parasite that is one of the major agents of the neglected tropical disease schistosomiasis. Recently, we identified aroylhydrazone derivatives capable of inhib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483f3472581fa7d612fccb340c16c01f
https://hal.archives-ouvertes.fr/hal-03227476
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10
Schistosoma mansoni NAD+ catabolizing enzyme: Identification of key residues in catalysis
Autor: Hélène Muller-Steffner, Esther Kellenberger, Isabelle Kuhn, Francis Schuber
Publikováno v: Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2013, 1834 (12), pp.2520-2527. ⟨10.1016/j.bbapap.2013.09.002⟩
Schistosoma mansoni NAD+ catabolizing enzyme (SmNACE), a distant homolog of mammalian CD38, shows significant structural and functional analogy to the members of the CD38/ADP-ribosyl cyclase family. The hallmark of SmNACE is the lack of ADP-ribosyl c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc28e244fb7aacf27a0d798fd4bb1300
https://doi.org/10.1016/j.bbapap.2013.09.002
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