Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Isabelle J. Marié"'
Autor:
Qinjian Li, Xiaoqi Wang, Qingxiao Song, Shijie Yang, Xiwei Wu, Dongyun Yang, Isabelle J. Marié, Hanjun Qin, Moqian Zheng, Ubaydah Nasri, Xiaohui Kong, Bixin Wang, Elizabeth Lizhar, Kaniel Cassady, Josh Tompkins, David Levy, Paul J. Martin, Xi Zhang, Defu Zeng
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 15 (2023)
STAT3 deficiency (STAT3–/–) in donor T cells prevents graft-versus-host disease (GVHD), but the impact on graft-versus-leukemia (GVL) activity and mechanisms of GVHD prevention remains unclear. Here, using murine models of GVHD, we show that STAT
Externí odkaz:
https://doaj.org/article/aff5b3ae62254d4ba378147ae1971705
Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome
Autor:
Isabelle J Marié, Lara Brambilla, Doua Azzouz, Ze Chen, Gisele V Baracho, Azlann Arnett, Haiyan S Li, Weiguo Liu, Luisa Cimmino, Pratip Chattopadhyay, Gregg Silverman, Stephanie S Watowich, Bernard Khor, David E Levy
Publikováno v:
eLife, Vol 10 (2021)
Maintenance of immune homeostasis involves a synergistic relationship between the host and the microbiome. Canonical interferon (IFN) signaling controls responses to acute microbial infection, through engagement of the STAT1 transcription factor. How
Externí odkaz:
https://doaj.org/article/982a4035ae764dbdbb7abc2f4d9fe2a7
Autor:
Alissa M Pham, Felicia Gilfoy Santa Maria, Tanaya Lahiri, Eugene Friedman, Isabelle J Marié, David E Levy
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005489 (2016)
Sensing invading pathogens early in infection is critical for establishing host defense. Two cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) induction in response to viral infection. Mounting evidence suggests tha
Externí odkaz:
https://doaj.org/article/cb33bc7fc130467bb092f0b5d42cdf1e
Autor:
Felipe, Valença-Pereira, Qian, Fang, Isabelle J, Marié, Emily L, Giddings, Karen A, Fortner, Rui, Yang, Alejandro V, Villarino, Yina H, Huang, David A, Frank, Haitao, Wen, David E, Levy, Mercedes, Rincon
Publikováno v:
Proc Natl Acad Sci U S A
Interleukin 6 (IL-6) is known to regulate the CD4 T cell function by inducing gene expression of a number of cytokines through activation of Stat3 transcription factor. Here, we reveal that IL-6 strengthens the mechanics of CD4 T cells. The presence
Autor:
Azlann, Arnett, Keagan G, Moo, Kaitlin J, Flynn, Thomas B, Sundberg, Liv, Johannessen, Alykhan F, Shamji, Nathanael S, Gray, Thomas, Decker, Ye, Zheng, Vivian H, Gersuk, Ziaur S, Rahman, David E, Levy, Isabelle J, Marié, Peter S, Linsley, Ramnik J, Xavier, Bernard, Khor
Publikováno v:
Mol Cell Biol
Immune health requires innate and adaptive immune cells to engage precisely balanced pro- and anti-inflammatory forces. We employ the concept of chemical immunophenotypes to classify small molecules functionally or mechanistically according to their