Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Isabelle I. Salles"'
Autor:
Adela Constantinescu-Bercu, Yuxiao A. Wang, Kevin J. Woollard, Pierre Mangin, Karen Vanhoorelbeke, James T.B. Crawley, Isabelle I. Salles-Crawley
Publikováno v:
Haematologica, Vol 107, Iss 4 (2021)
The GPIbT-VWF A1 domain interaction is essential for platelet tethering under high shear. Synergy between GPIbα and GPVI signaling machineries has been suggested previously, however its molecular mechanism remains unclear. We generated a novel GPIb
Externí odkaz:
https://doaj.org/article/419fac8344784940b97373c9c7ae8edd
Autor:
Adela Constantinescu-Bercu, Luigi Grassi, Mattia Frontini, Isabelle I Salles-Crawley, Kevin Woollard, James TB Crawley
Publikováno v:
eLife, Vol 9 (2020)
Platelet-neutrophil interactions are important for innate immunity, but also contribute to the pathogenesis of deep vein thrombosis, myocardial infarction and stroke. Here we report that, under flow, von Willebrand factor/glycoprotein Ibα-dependent
Externí odkaz:
https://doaj.org/article/968a474c4c384d029e4443e500a51ab0
Autor:
Amna Malik, Anwar A. Sayed, Panpan Han, Michelle M.H. Tan, Eleanor Watt, Adela Constantinescu-Bercu, Alexander T.H. Cocker, Ahmad Khoder, Rocel Christine Saputil, Emma V. Thorley, Ariam Teklemichael, Yunchuan Ding, Alice C.J. Hart, Haiyu Zhang, Wayne A. Mitchell, Nesrina Imami, James T.B. Crawley, Isabelle I. Salles-Crawley, James B. Bussel, James L. Zehnder, Stuart Paul Adams, Bing M. Zhang, Nichola Cooper
Publikováno v:
Blood.
Immune thrombocytopenia (ITP) is traditionally considered an antibody-mediated disease. However, a number of features suggest alternative mechanisms of platelet destruction. In this study, we use a multi-dimensional approach to explore the role of cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a66879e7fbf40d1a945d07bd6131a33
https://doi.org/10.1182/blood.2022018380
https://doi.org/10.1182/blood.2022018380
Autor:
Yuxiao Alice Wang, Kevin J. Woollard, Pierre Mangin, James T. B. Crawley, Isabelle I. Salles-Crawley, Adela Constantinescu-Bercu, Karen Vanhoorelbeke
Synergy between GPIbα and GPVI signaling machineries has been suggested previously, however its molecular mechanism remains unclear. We generated a novel GPIbα transgenic mouse (GPIbαΔsig/Δsig) by CRISPR-Cas9 technology to delete the last 24 res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4962ceff83f44d48138ea40343a4d296
Autor:
Laura J. Mereweather, Adela Constantinescu-Bercu, James T. B. Crawley, Isabelle I. Salles-Crawley
Publikováno v:
International Journal of Molecular Sciences. 24:1266
Platelets are essential for the formation of a haemostatic plug to prevent bleeding, while neutrophils are the guardians of our immune defences against invading pathogens. The interplay between platelets and innate immunity, and subsequent triggering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58f2d0ec38ee3477429a546a3953056
https://doi.org/10.3390/ijms24021266
https://doi.org/10.3390/ijms24021266
Autor:
Tim Thijs, Katleen Broos, Stefaan J Soenen, Aline Vandenbulcke, Karen Vanhoorelbeke, Hans Deckmyn, Isabelle I Salles-Crawley
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132899 (2015)
In recent years, candidate genes and proteins implicated in platelet function have been identified by various genomic approaches. To elucidate their exact role, we aimed to develop a method to apply miRNA interference in platelet progenitor cells by
Externí odkaz:
https://doaj.org/article/169a802e306b4e46b8a038eac71fea81
Publikováno v:
Journal of Thrombosis and Haemostasis. 18:1556-1558
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a01c79e6cc8c18f93714d80ce1f4fd
https://doi.org/10.1111/jth.14834
https://doi.org/10.1111/jth.14834
Autor:
Xuhan Liu, Boram Gu, Isabelle I. Salles-Crawley, Xiao Yun Xu, Michael Emerson, Colin Longstaff, Simon A. McG. Thom, Rongjun Chen, Yu Huang, Jie Ren, Li Yu, Kirk A. Taylor, Alun D. Hughes
Publikováno v:
Science Advances
Bioinspired nanovesicles enable activated platelet–targeted delivery of tissue plasminogen activator for effective thrombolysis.
Clinical use of tissue plasminogen activator (tPA) in thrombolytic therapy is limited by its short circulation tim
Clinical use of tissue plasminogen activator (tPA) in thrombolytic therapy is limited by its short circulation tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e402c795cc5a0f5858fca545c6d387
https://pubmed.ncbi.nlm.nih.gov/34078604
https://pubmed.ncbi.nlm.nih.gov/34078604