AB186 Inhibits Migration of Triple-Negative Breast Cancer Cells and Interacts with α-Tubulin

Autor: Marine Geoffroy, Marine Lemesle, Alexandra Kleinclauss, Sabine Mazerbourg, Levy Batista, Muriel Barberi-Heyob, Thierry Bastogne, Wilfrid Boireau, Alain Rouleau, Dorian Dupommier, Michel Boisbrun, Corinne Comoy, Stéphane Flament, Isabelle Grillier-Vuissoz, Sandra Kuntz

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, 23 (12), pp.6859. ⟨10.3390/ijms23126859⟩
International Journal of Molecular Sciences; Volume 23; Issue 12; Pages: 6859

International audience; Breast cancer is one of the leading causes of cancer-related death among females worldwide. A major challenge is to develop innovative therapy in order to treat breast cancer subtypes resistant to current treatment. In the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd7c9c08564ae6e1f4e819996f0ed51
https://pubmed.ncbi.nlm.nih.gov/35743305

Troglitazone Derivatives Induce Early Modifications of the Cytoskeleton and Inhibition of Migration in Breast Cancer Cells

Autor: Geoffroy Marine, Lemesle Marine, Kleinclauss Alexandra, Mazerbourg Sabine, Batista Levy, BarberiHeyob Muriel, Bastogne Thierry, Boireau Wilfrid, Alain Rouleau, Dupommier Dorian, Boisbrun Michel, Comoy Corinne, Flament Stéphane, Isabelle Grillier-Vuissoz, Kuntz Sandra

Background The 5-years survival rate of breast cancer patients is around 90%. Unfortunately, some types of tumors, especially the triple negative breast cancer (TNBC), present chemo-resistance and have a higher relapse 5 years post-treatment due to m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::208f65d538482e020a3a31470a5125e6
https://doi.org/10.21203/rs.3.rs-911353/v1

Synthesis and evaluation of new designed multiple ligands directed towards both peroxisome proliferator-activated receptor-γ and angiotensin II type 1 receptor

Autor: Isabelle Lartaud, Gérald Monard, Isabelle Grillier-Vuissoz, Sébastien Foulquier, Daniel Henrion, François Dupuis, Maxime Meyer, Linda Grimaud, Michel Boisbrun, Stéphane Flament

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 158, pp.334-352. ⟨10.1016/j.ejmech.2018.08.082⟩
European Journal of Medicinal Chemistry, 158, 334-352. Elsevier France-Éditions Scientifiques et Medicales Elsevier

International audience; Because of the complex biological networks, many pathologic disorders fail to be treated with a molecule directed towards a single target. Thus, combination therapies are often necessary, but they have many drawbacks. An alter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99baff238ee404e4fecba1a0da9b991
https://pubmed.ncbi.nlm.nih.gov/30223121

Pro-apoptotic effect of Δ2-TGZ in 'claudin-1-low' triple-negative breast cancer cells: involvement of claudin-1

Autor: Stéphane Flament, Alexandra Kleinclauss, Sébastien Hupont, Marine Geoffroy, Stéphanie Grandemange, Isabelle Grillier-Vuissoz, Michel Boisbrun, Sandra Kuntz

Publikováno v: Breast Cancer Research and Treatment
Breast Cancer Research and Treatment, Springer Verlag, 2017, 165 (3), pp.517-527. ⟨10.1007/s10549-017-4378-2⟩

International audience; PURPOSE:40% of triple-negative breast cancer (TNBC) do not express claudin-1, a major constituent of tight junction. Patients with these "claudin-1-low" tumors present a higher relapse incidence. A major challenge in oncology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e07d1c1e66775d29474ba16b3dac5c2
https://hal.archives-ouvertes.fr/hal-01589665

EGR1 expression: A calcium and ERK1/2 mediated PPARγ-independent event involved in the antiproliferative effect of 15-deoxy-Δ12,14-prostaglandin J2 and thiazolidinediones in breast cancer cells

Autor: Sarra Chbicheb, Jean-Luc Rodeau, Yves Chapleur, Stéphane Salamone, Stéphane Flament, Michel Boisbrun, Sabine Mazerbourg, Xiao Yao, Isabelle Grillier-Vuissoz, Daniel Spohn, Gerald Thiel

Publikováno v: Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2011, 81 (9), pp.1087. ⟨10.1016/j.bcp.2011.02.006⟩
Biochemical Pharmacology, Elsevier, 2011, 81 (9), pp.1087-1097. ⟨10.1016/j.bcp.2011.02.006⟩

International audience; Our aim was to get new information about the Peroxisome Proliferator Activated Receptor gamma (PPARγ)-independent pathway involved in the antiproliferative action of PPARγ ligands in breast cancer cells. We investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45991268e1ee717a378afcac0b75860d
https://doi.org/10.1016/j.bcp.2011.02.006