The bile acid receptor TGR5 and cholestasis

Autor: Grégory Merlen, Valeska Bidault-Jourdainne, Isabelle Doignon, Isabelle Garcin, Thierry Tordjmann

Publikováno v: Exploration of Digestive Diseases, Vol 1, Iss 3, Pp 154-167 (2022)

During liver injury and cholestasis, the mechanisms allowing the organ to protect itself with the aim of maintaining biliary homeostasis are not completely understood. Central to their biological roles, bile acids (BAs) and their receptors constitute

Externí odkaz: https://doaj.org/article/5eb26a4edc6e4ca9940279df42c7f755

TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload

Autor: Valeska Bidault-Jourdainne, Grégory Merlen, Mathilde Glénisson, Isabelle Doignon, Isabelle Garcin, Noémie Péan, Raphael Boisgard, José Ursic-Bedoya, Matteo Serino, Christoph Ullmer, Lydie Humbert, Ahmed Abdelrafee, Nicolas Golse, Eric Vibert, Jean-Charles Duclos-Vallée, Dominique Rainteau, Thierry Tordjmann

Publikováno v: JHEP Reports, Vol 3, Iss 2, Pp 100214- (2021)

Background & Aims: As the composition of the bile acid (BA) pool has a major impact on liver pathophysiology, we studied its regulation by the BA receptor Takeda G protein coupled receptor (TGR5), which promotes hepatoprotection against BA overload.

Externí odkaz: https://doaj.org/article/952de4425e4c494c96605a1be4552e7b

Calcium Signalling and Liver Regeneration

Autor: Isabelle Garcin, Thierry Tordjmann

Publikováno v: International Journal of Hepatology, Vol 2012 (2012)

After partial hepatectomy (PH) the initial mass of the organ is restored through a complex network of cellular interactions that orchestrate both proliferative and hepatoprotective signalling cascades. Among agonists involved in this network many of

Externí odkaz: https://doaj.org/article/9ca56f016daf4a1c95d17195f589b8aa

Hepatoprotective impact of the bile acid receptor TGR5

Autor: Gregory Merlen, Dominique Rainteau, Valeska Bidault-Jourdainne, Lydie Humbert, Isabelle Doignon, Nicolas Kahale, Mathilde Glénisson, Isabelle Garcin, José Ursic-Bedoya, Thierry Tordjmann

Publikováno v: Liver International
Liver International, Wiley-Blackwell, 2020, 40 (5), pp.1005-1015. ⟨10.1111/liv.14427⟩

International audience; During liver repair after injury, bile secretion has to be tightly modulated in order to preserve liver parenchyma from bile acid (BA)-induced injury. The mechanisms allowing the liver to maintain biliary homeostasis during re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d0633c0d9a176ab15a6fd92c6f0a0d
https://doi.org/10.1111/liv.14427

Effect of CFTR correctors on the traffic and the function of intracellularly retained ABCB4 variants

Autor: Ágota Tóth, Emmanuel Jacquemin, Isabelle Garcin, Jean-Louis Delaunay, Chantal Housset, Florent Di Meo, Angelika Janaszkiewicz, Alix Bruneau, Thomas Falguières, Martine Lapalus, Anne-Marie Durand-Schneider, Tounsia Aït-Slimane, Elodie Mareux, Emmanuel Gonzales, Virginie Vauthier, Amel Ben Saad

Publikováno v: Liver International
Liver International, Wiley-Blackwell, 2021, 41 (6), pp.1344-1357. ⟨10.1111/liv.14839⟩
Liver International, 2021, 41 (6), pp.1344-1357. ⟨10.1111/liv.14839⟩

International audience; Background & aim: ABCB4 is expressed at the canalicular membrane of hepatocytes. This ATP-binding cassette (ABC) transporter is responsible for the secretion of phosphatidylcholine into bile canaliculi. Missense genetic variat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1d478a09ed70ab74550169e6e80f1e
https://hal.sorbonne-universite.fr/hal-03263358/document