A mesoporous metal–organic framework used to sustainably release copper( ii ) into reducing aqueous media to promote the CuAAC click reaction

Autor: Pascal Hoffmann, Christian Lherbet, Isabelle Fabing, Marie-Claire Barthélémy, Yann Borjon-Piron, Christophe Laurent, Alain Vigroux

Publikováno v: RSC Advances
RSC Advances, 2022, 12 (41), pp.26825-26833. ⟨10.1039/d2ra04298c⟩

Cr-MIL-101-NH2 (MOF1) has been used to encapsulate large amounts of copper sulfate and the resulting loaded material, Cu@MOF1, was successfully used to promote the CuAAC click reaction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e228da902258f0e8fc80d86ee7dd9a
https://hal.science/hal-03785805

Isolation and identification of ten new sildenafil derivatives in an alleged herbal supplement for sexual enhancement

Autor: Isabelle Fabing, Frédéric Rodriguez, Gaëtan Assemat, Robert Martino, Véronique Gilard, Myriam Malet-Martino, Stéphane Balayssac, Yves Génisson, Nathalie Martins-Froment

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2020, 191, pp.113482. ⟨10.1016/j.jpba.2020.113482⟩
Journal of Pharmaceutical and Biomedical Analysis, 2020, 191, pp.113482. ⟨10.1016/j.jpba.2020.113482⟩

International audience; A sexual enhancer dietary supplement in pre-commercialization phase was analyzed. It 18 contained the two phosphodiesterase-5 inhibitors (PDE-5i) sildenafil and methisosildenafil as 19 major adulterants. Fourteen more sildenaf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa2455b1cb204f047c5eddf0a11d956
https://hal.archives-ouvertes.fr/hal-02966885/document

Concise asymmetric synthesis of new enantiomeric

Autor: Tessa, Castellan, Virginie, Garcia, Frédéric, Rodriguez, Isabelle, Fabing, Yevhenii, Shchukin, My Lan, Tran, Stéphanie, Ballereau, Thierry, Levade, Yves, Génisson, Cécile, Dehoux

Publikováno v: Organicbiomolecular chemistry. 18(39)

A concise and asymmetric synthesis of the enantiomeric pyrrolidines 2 and ent-2 are herein reported. Both enantiomers were assessed as β-GCase inhibitors. While compound ent-2 acted as a poor competitive inhibitor, its enantiomer 2 proved to be a po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f776b4d0d37915e838a098e353c76472
https://pubmed.ncbi.nlm.nih.gov/32975266

Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration

Autor: Giovanny Garavito, Ben M. Dunn, Silvia Galiano, David W. Wright, Miguel Quiliano, Eric Deharo, Adriana Pabón, Nathan E. Goldfarb, Adela López de Cerain, Ignacio Aldana, Adela Mendoza, Isabelle Fabing, Kim Y. Fong, Ariane Vettorazzi, Silvia Pérez-Silanes

Publikováno v: International journal for parasitology. Drugs and drug resistance
International journal for parasitology. Drugs and drug resistance, Elsevier, 2016, 6 (3), pp.184-198. ⟨10.1016/j.ijpddr.2016.09.004⟩
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 3, Pp 184-198 (2016)
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
International journal for parasitology. Drugs and drug resistance, 2016, 6 (3), pp.184-198. ⟨10.1016/j.ijpddr.2016.09.004⟩
International Journal for Parasitology: Drugs and Drug Resistance

Synthesis of new 1-aryl-3-substituted propanol derivatives followed by structure-activity relationship, in silico drug-likeness, cytotoxicity, genotoxicity, in silico metabolism, in silico pharmacophore modeling, and in vivo studies led to the identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff4cd359ed61632808953a969615398
https://doi.org/10.1016/j.ijpddr.2016.09.004

Ethynylogation approach in pharmacophore design: from alkynyl-to butadiynyl-carbinols vs antitumoral cytotoxicity

Autor: Valérie Maraval, Yves Génisson, Remi Chauvin, Isabelle Fabing, Etienne Joly, Nathalie Saffon-Merceron, Dymytrii Listunov

Publikováno v: Tetrahedron
Tetrahedron, Elsevier, 2016, 72 (42), pp.6697-6704. ⟨10.1016/j.tet.2016.09.001⟩

International audience; Ethynylogation of a chiral lipidic dialkynylcarbinol (DAC), identified as a lead for cytotoxicity against HCT116 cancer cells, is shown to typify the butadiynyl-alkynylcarbinol (BAC) unit as a new pharmacophore. The enantiomer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a27cb9dbc9c7c7386fef07070c59ef5
https://doi.org/10.1016/j.tet.2016.09.001