Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Isabelle Domingo"'
Autor:
Alison Robert, David Crottès, Jérôme Bourgeais, Naig Gueguen, Arnaud Chevrollier, Jean-François Dumas, Stéphane Servais, Isabelle Domingo, Stéphanie Chadet, Julien Sobilo, Olivier Hérault, Thierry Lecomte, Christophe Vandier, William Raoul, Maxime Guéguinou
Publikováno v:
PLoS Biology, Vol 22, Iss 10, p e3002854 (2024)
The mitochondrial Ca2+ uniporter (MCU) plays crucial role in intramitochondrial Ca2+ uptake, allowing Ca2+-dependent activation of oxidative metabolism. In recent decades, the role of MCU pore-forming proteins has been highlighted in cancer. However,
Externí odkaz:
https://doaj.org/article/d921cf1a11eb48efbb81622c970372c0
Autor:
Marion Papin, Delphine Fontaine, Caroline Goupille, Sandy Figiel, Isabelle Domingo, Michelle Pinault, Cyrille Guimaraes, Nina Guyon, Pierre François Cartron, Patrick Emond, Antoine Lefevre, Maxime Gueguinou, David Crottès, Paul-Alain Jaffrès, Lobna Ouldamer, Karine Maheo, Gaëlle Fromont, Marie Potier-Cartereau, Philippe Bougnoux, Aurélie Chantôme, Christophe Vandier
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 5, Pp 100544- (2024)
SK3 channels are potassium channels found to promote tumor aggressiveness. We have previously demonstrated that SK3 is regulated by synthetic ether lipids, but the role of endogenous ether lipids is unknown. Here, we have studied the role of endogeno
Externí odkaz:
https://doaj.org/article/c60252b33184451bac3e20c91baf77d9
Autor:
Emeline Bon, Virginie Driffort, Frédéric Gradek, Carlos Martinez-Caceres, Monique Anchelin, Pablo Pelegrin, Maria-Luisa Cayuela, Séverine Marionneau-Lambot, Thibauld Oullier, Roseline Guibon, Gaëlle Fromont, Jorge L. Gutierrez-Pajares, Isabelle Domingo, Eric Piver, Alain Moreau, Julien Burlaud-Gaillard, Philippe G. Frank, Stéphan Chevalier, Pierre Besson, Sébastien Roger
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
The capacity of cancer cells to migrate is intimately linked to their ability to induce metastasis. Here the authors show that the sodium channel β4 subunit regulates breast cancer cell migration via inhibition of RhoA activation, independently from
Externí odkaz:
https://doaj.org/article/b868edb8e4164085a3574d6fbc6f262e
Autor:
Aurélie Chantôme, G.A. Titaux-Delgado, Christophe Vandier, Isabelle Domingo, Federico del Río-Portilla, Marlen Mayorga-Flores, Rodrigo Galindo-Murillo, Carolina Monserrath Melchor-Meneses
Publikováno v:
ACS Med Chem Lett
[Image: see text] Peptide-based therapy against cancer is a field of great interest for biomedical developments. Since it was shown that SK3 channels promote cancer cell migration and metastatic development, we started using these channels as targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5561e100746100fa244ae29f1344ced3
https://doi.org/10.1021/acsmedchemlett.0c00300
https://doi.org/10.1021/acsmedchemlett.0c00300
Autor:
Marie Potier-Cartereau, Gaëlle Fromont, Côme Pasqualin, Karine Mahéo, Roseline Guibon, Fanny Bery, Franck Bruyère, Véronique Maupoil, Christophe Vandier, Sandy Figiel, Isabelle Domingo
Publikováno v:
The American Journal of Pathology. 189:1268-1275
In prostate cancer research, there is a lack of valuable preclinical models. Tumor cell heterogeneity and sensitivity to microenvironment signals, such as hypoxia or extracellular calcium concentration, are difficult to reproduce. Here, we developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d93cb2c6acc2a4cbc269fe39a973c54
https://doi.org/10.1016/j.ajpath.2019.02.017
https://doi.org/10.1016/j.ajpath.2019.02.017
Autor:
Sandy, Figiel, Côme, Pasqualin, Fanny, Bery, Veronique, Maupoil, Christophe, Vandier, Marie, Potier-Cartereau, Isabelle, Domingo, Roseline, Guibon, Franck, Bruyere, Karine, Maheo, Gaelle, Fromont
Publikováno v:
American Journal of Pathology
American Journal of Pathology, 2019, 189 (6), pp.1268-1275. ⟨10.1016/j.ajpath.2019.02.017⟩
American Journal of Pathology, American Society for Investigative Pathology, 2019, 189 (6), pp.1268-1275. ⟨10.1016/j.ajpath.2019.02.017⟩
American Journal of Pathology, 2019, 189 (6), pp.1268-1275. ⟨10.1016/j.ajpath.2019.02.017⟩
American Journal of Pathology, American Society for Investigative Pathology, 2019, 189 (6), pp.1268-1275. ⟨10.1016/j.ajpath.2019.02.017⟩
International audience; In prostate cancer research, there is a lack of valuable preclinical models. Tumor cell heterogeneity and sensitivity to microenvironment signals, such as hypoxia or extracellular calcium concentration, are difficult to reprod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::20c7e5248924a5e95f09b1730be3705a
https://hal.science/hal-02460711/document
https://hal.science/hal-02460711/document
Autor:
Gaëlle Fromont, Pierre Besson, Isabelle Domingo, Maria-Luisa Cayuela, Monique Anchelin, Pablo Pelegrín, Alain Moreau, Stephan Chevalier, Eric Piver, Sébastien Roger, Carlos Martinez-Caceres, Thibauld Oullier, Jorge L. Gutierrez-Pajares, Philippe G. Frank, Julien Burlaud-Gaillard, Emeline Bon, Séverine Marionneau-Lambot, Frédéric Gradek, Virginie Driffort, Roseline Guibon
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2016, 7 (1), ⟨10.1038/ncomms13648⟩
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
Nature Communications, Nature Publishing Group, 2016, 7 (1), ⟨10.1038/ncomms13648⟩
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
The development of metastases largely relies on the capacity of cancer cells to invade extracellular matrices (ECM) using two invasion modes termed ‘mesenchymal' and ‘amoeboid', with possible transitions between these modes. Here we show that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd0a2576788c2be033b38f020e80a78
https://hal.archives-ouvertes.fr/hal-03471169
https://hal.archives-ouvertes.fr/hal-03471169
Autor:
Stephan Chevalier, Cyrille Guimaraes, Michelle Pinault, Philippe Bougnoux, Isabelle Domingo, Caroline Goupille, Charly Blanc, Lucie Chauvin, Karine Mahéo
Publikováno v:
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, Elsevier, 2016, 1861 (4), pp.380-390. ⟨10.1016/j.bbalip.2016.01.012⟩
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, Elsevier, 2016, 1861 (4), pp.380-390. ⟨10.1016/j.bbalip.2016.01.012⟩
International audience; Taxanes can induce drug resistance by increasing signaling pathways such as PI3K/Akt and ERK, which promote survival and cell growth in human cancer cells. We have previously shown that long chain n-3 polyunsaturated fatty aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18cf77993a35063e340484aaf0bb9bc
https://hal.archives-ouvertes.fr/hal-02959133
https://hal.archives-ouvertes.fr/hal-02959133
Autor:
Stephan Chevalier, Sébastien Papot, Brigitte Renoux, Caroline Goupille, Philippe Bougnoux, Isabelle Domingo, Charles Dussiau, Karine Mahéo
Publikováno v:
Clinical Lipidology. 5:233-243
The important factor determining breast cancer outcome is tumor cell sensitivity to cytotoxic agents. Most anticancer drugs lack intrinsic anti-tumor selectivity, provoking adverse effects in healthy nontumor tissues. As a result, drugs cannot always
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::397b5eb308bd3fc5db43d27061e81a9c
https://doi.org/10.2217/clp.10.12
https://doi.org/10.2217/clp.10.12
Autor:
Aurélie Chantôme, Marion Papin, Hélène Couthon, Alicia Bauduin, Paul-Alain Jaffrès, Jose Requejo-Isidro, Christophe Vandier, Laure Deschamps
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2021, 209, pp.112894. ⟨10.1016/j.ejmech.2020.112894⟩
European Journal of Medicinal Chemistry, 2021, 209, pp.112894. ⟨10.1016/j.ejmech.2020.112894⟩
European Journal of Medicinal Chemistry, Elsevier, 2021, 209, pp.112894. ⟨10.1016/j.ejmech.2020.112894⟩
European Journal of Medicinal Chemistry, 2021, 209, pp.112894. ⟨10.1016/j.ejmech.2020.112894⟩
We report the synthesis of three bioactive pyrene-based fluorescent analogues of Ohmline which is the most efficient and selective inhibitor of SK3 ion channel. The interaction of these Ohmline-pyrene (OP1-3) with liposomes of different composition r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be511f0c54c1a46cc00df01dc154d59
https://hal.univ-brest.fr/hal-02997273
https://hal.univ-brest.fr/hal-02997273