Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Isabelle Demeestere"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The Hippo pathway plays a crucial role in the regulation of follicular activation, which constitutes the first step of the folliculogenesis process. Disruption of this pathway occurs in several non-physiological contexts, after fragmentation
Externí odkaz:
https://doaj.org/article/3d0ee25ff87b4278ab66e10ba8493639
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 204 (2023)
Hereditary cancers mostly affect the adolescent and young adult population (AYA) at reproductive age. Mutations in BReast CAncer (BRCA) genes are responsible for the majority of cases of hereditary breast and ovarian cancer. BRCA1 and BRCA2 act as tu
Externí odkaz:
https://doaj.org/article/3b13241768f9433eaf1998bc9623ad47
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 460 (2023)
Oncological treatments have dramatically improved over the last decade, and as a result, survival rates for cancer patients have also improved. Quality of life, including concerns about fertility, has become a major focus for both oncologists and pat
Externí odkaz:
https://doaj.org/article/1734e98896ca41bbb86185bbbd457bb8
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16593 (2023)
Although effective in terms of the chances of future live birth, the current methods for fertility preservation, such as oocyte, embryo, or ovarian tissue cryopreservation, cannot be offered to all cancer patients in all clinical contexts. Expanding
Externí odkaz:
https://doaj.org/article/fec363a7d959448f86438a2bb8d3a29f
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Pharmacological approaches offer a non-invasive and promising option for fertility preservation in young female cancer patients undergoing gonadotoxic therapy. The GnRH-agonists are the only clinically available drugs in this indication, but
Externí odkaz:
https://doaj.org/article/3fff9861609146b6ae260afae56bee3d
Autor:
Graziana Scavone, Silvia Ottonello, Eva Blondeaux, Luca Arecco, Paola Scaruffi, Sara Stigliani, Barbara Cardinali, Roberto Borea, Michele Paudice, Valerio G. Vellone, Margherita Condorelli, Isabelle Demeestere, Matteo Lambertini
Publikováno v:
Cancers, Vol 15, Iss 20, p 4923 (2023)
The combination of cyclin-dependent kinase (CDK) 4/6 inhibitors with endocrine therapy is the standard treatment for patients with HR+/HER2− advanced breast cancer. Recently, this combination has also entered the early setting as an adjuvant treatm
Externí odkaz:
https://doaj.org/article/a8358aece5ae4e8487b3be04f4971796
Autor:
Elze Prokurotaite, Margherita Condorelli, Julie Dechene, Jason Bouziotis, Matteo Lambertini, Isabelle Demeestere
Publikováno v:
Life, Vol 13, Iss 4, p 930 (2023)
Background: Several studies have suggested that breast cancer (BC) and germline BRCA pathogenic variants (gBRCA PVs) could have a deleterious impact on ovarian reserve. Nevertheless, data are limited and mixed. Our objective was to evaluate the perfo
Externí odkaz:
https://doaj.org/article/3bf4191a8add4d24bdf394c76d9094c6
Autor:
Françoise Rothé, Matteo Lambertini, Oranite Goldrat, Marion Maetens, Yacine Bareche, Jeremy Blanc, Ghizlane Rouas, Denis Larsimont, Christos Sotiriou, Michail Ignatiadis, Isabelle Demeestere
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundCurrent fertility preservation strategies for young breast cancer patients planning a future motherhood include the association of controlled ovarian stimulation with the aromatase inhibitor letrozole (let-COS) to harvest mature oocytes whi
Externí odkaz:
https://doaj.org/article/a9a29b19dc604953a0ca62b03b4edaef
Autor:
Oranite Goldrat, Geraldine Van Den Steen, Eric Gonzalez-Merino, Julie Dechène, Christine Gervy, Anne Delbaere, Fabienne Devreker, Viviane De Maertelaer, Isabelle Demeestere
Publikováno v:
Reproductive Biology and Endocrinology, Vol 17, Iss 1, Pp 1-9 (2019)
Abstract Background Fertility preservation (FP) protocols in case of breast cancer (BC) include mature oocyte cryopreservation following letrozole associated controlled ovarian hyperstimulation (Let-COH). To date, the impact of Let-COH on the follicu
Externí odkaz:
https://doaj.org/article/e7b796bf57ca41369eb54b9aae89e6de
Autor:
Benedetta Bonardi, Claudia Massarotti, Marco Bruzzone, Oranite Goldrat, Giorgia Mangili, Paola Anserini, Stefano Spinaci, Luca Arecco, Lucia Del Mastro, Marcello Ceppi, Isabelle Demeestere, Matteo Lambertini
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Background: The co-administration of letrozole during controlled ovarian stimulation (COS) with gonadotropins is used to limit the potentially harmful effects of a supra-physiological rise in estrogen levels on hormone-sensitive cancers. However, the
Externí odkaz:
https://doaj.org/article/f6ed57eacde54587a72d7599374211f1