Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Isabelle Castan-Laurell"'
Autor:
Céline Saint-Laurent, Laurène Mazeyrie, Mylène Tajan, Romain Paccoud, Isabelle Castan-Laurell, Philippe Valet, Thomas Edouard, Jean-Philippe Pradère, Cédric Dray, Armelle Yart
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2139 (2022)
The SH2 containing protein tyrosine phosphatase 2(SHP2) plays essential roles in fundamental signaling pathways, conferring on it versatile physiological functions during development and in homeostasis maintenance, and leading to major pathological o
Externí odkaz:
https://doaj.org/article/c13d014cc5f94d64bb7365baef8ef77b
Autor:
Philippe Valet, Genevieéve Tavernier, Isabelle Castan-Laurell, Jean Sébastien Saulnier-Blache, Dominique Langin
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 6, Pp 835-860 (2002)
The World Health Organization has recognized obesity as a health problem of pandemic proportions. Recent work led to major breakthroughs in the understanding of the molecular basis of adipose tissue development with the cloning and characterization o
Externí odkaz:
https://doaj.org/article/708cddb37ce941e3a846f7bce1b1a57f
Autor:
Chantal Bertrand, Angelica Pignalosa, Estelle Wanecq, Chloé Rancoule, Aurélie Batut, Simon Deleruyelle, Lillà Lionetti, Philippe Valet, Isabelle Castan-Laurell
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78874 (2013)
Various studies have shown that eicosapentaenoic acid (EPA) has beneficial effects on obesity and associated disorders. Apelin, the ligand of APJ receptor also exerts insulin-sensitizing effects especially by improving muscle metabolism. EPA has been
Externí odkaz:
https://doaj.org/article/69049bb823e84070a1cd827a27d104fa
Autor:
Jean Personnaz, Enzo Piccolo, Alizée Dortignac, Jason S. Iacovoni, Jérôme Mariette, Vincent Rocher, Arnaud Polizzi, Aurélie Batut, Simon Deleruyelle, Lucas Bourdens, Océane Delos, Lucie Combes-Soia, Romain Paccoud, Elsa Moreau, Frédéric Martins, Thomas Clouaire, Fadila Benhamed, Alexandra Montagner, Walter Wahli, Robert F. Schwabe, Armelle Yart, Isabelle Castan-Laurell, Justine Bertrand-Michel, Odile Burlet-Schiltz, Catherine Postic, Pierre-Damien Denechaud, Cédric Moro, Gaelle Legube, Chih-Hao Lee, Hervé Guillou, Philippe Valet, Cédric Dray, Jean-Philippe Pradère
Publikováno v:
Science Advances
Science Advances, 2022, 8 (12), ⟨10.1126/sciadv.abg9055⟩
Science Advances, 2022, 8 (12), ⟨10.1126/sciadv.abg9055⟩
Dysregulations of lipid metabolism in the liver may trigger steatosis progression, leading to potentially severe clinical consequences such as nonalcoholic fatty liver diseases (NAFLDs). Molecular mechanisms underlying liver lipogenesis are very comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79eac556bb1af4b744201d38bffcecbf
https://hal.inrae.fr/hal-03624265/document
https://hal.inrae.fr/hal-03624265/document
Autor:
Romain Paccoud, Arnaud Polizzi, Isabelle Castan-Laurell, Jérôme Mariette, Robert F. Schwabe, W. Wahli, Frédéric Martins, Jason S. Iacovoni, Enzo Piccolo, Thomas Clouaire, Simon Deleruyelle, Chih-Hao Lee, Philippe Valet, Jean-Philippe Pradere, Gaëlle Legube, Fadila Benhamed, Hervé Guillou, Alexandra Montagner, Cedric Moro, Catherine Postic, Jean Personnaz, Elsa Moreau, Cédric Dray, Alizee Dortignac, Armelle Yart, Aurélie Batut
Dysregulations of lipid metabolism in the liver may trigger steatosis progression leading to potentially severe clinical consequences such as non-alcoholic fatty liver diseases (NAFLD). Molecular mechanisms underlying liver lipogenesis are very compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52bd111c8125f84f86d0f59c23a35b9e
https://doi.org/10.1101/2021.02.17.431446
https://doi.org/10.1101/2021.02.17.431446
Publikováno v:
Molecular and cellular endocrinology. 529
Apelin, a peptide with several active isoforms ranging from 36 to 12 amino acids and its receptor APJ, a G-protein-coupled receptor, are widely distributed. However, apelin has emerged as an adipokine more than fifteen years ago, integrating the fiel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd70234aba02893b65f2a926d57ff18
https://pubmed.ncbi.nlm.nih.gov/33838166
https://pubmed.ncbi.nlm.nih.gov/33838166
Autor:
Philippe Valet, Ronan Roussel, Ray El Boustany, Ophélie Pereira, Isabelle Castan-Laurell, Louis Potier, Gilberto Velho, Pierre Gourdy, Michel Marre, Frédéric Fumeron
Publikováno v:
Diabetes care. 43(2)
Apelin is a bioactive peptide and the endogenous ligand of APJ, a G-protein–coupled receptor. It is expressed in several organs and tissues including many regions of the central nervous system and the gastrointestinal tract, the heart, the lungs, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91f7cb0e58378959d128de20e57807a
https://pubmed.ncbi.nlm.nih.gov/31806652
https://pubmed.ncbi.nlm.nih.gov/31806652
Autor:
Sophie Le Gonidec, Philippe Valet, Nancy Geoffre, Jean-Philippe Pradere, Jean Personnaz, Cedric Moro, Isabelle Castan-Laurell, C. Bertrand, Aurélie Batut, Katie Louche, Simon Deleruyelle, Bernard Masri
Publikováno v:
Endocrine
Endocrine, Springer, 2018, 60 (1), pp.112-121. ⟨10.1007/s12020-018-1536-1⟩
Endocrine, Springer, 2018, 60 (1), pp.112-121. ⟨10.1007/s12020-018-1536-1⟩
Apelin treatment has been shown to improve insulin sensitivity in insulin resistant mice by acting in skeletal muscles. However, the effects of systemic apelin on the hepatic energy metabolism have not been addressed. We thus aimed to determine the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358b1b929b79b8e4d6cdbeee9ac9afbd
https://hal.archives-ouvertes.fr/hal-02393084
https://hal.archives-ouvertes.fr/hal-02393084
Publikováno v:
Obésité. 11:170-180
Steatosed liver, in obesity and insulin resistance, undergoes metabolic alterations but also in its secretome. The concept of hepatokines has been proposed very recently and this review proposes an up-to-date listing of the latest identified hepatoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68be2a3bd9c8730fed509b5516291656
https://doi.org/10.1007/s11690-015-0492-7
https://doi.org/10.1007/s11690-015-0492-7
Publikováno v:
médecine/sciences. 31:275-281
Le gène codant pour le récepteur de l’apeline (APJ) a été cloné dès 1993, et son ligand identifié en 1998. L’expression du récepteur APJ au niveau du système nerveux central, notamment dans l’hypothalamus, ainsi que dans divers tissus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f6a97da2e645276d7fd0c2769501239
https://doi.org/10.1051/medsci/20153103013
https://doi.org/10.1051/medsci/20153103013