Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Isabelle Castan"'
Autor:
Céline Saint-Laurent, Laurène Mazeyrie, Mylène Tajan, Romain Paccoud, Isabelle Castan-Laurell, Philippe Valet, Thomas Edouard, Jean-Philippe Pradère, Cédric Dray, Armelle Yart
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2139 (2022)
The SH2 containing protein tyrosine phosphatase 2(SHP2) plays essential roles in fundamental signaling pathways, conferring on it versatile physiological functions during development and in homeostasis maintenance, and leading to major pathological o
Externí odkaz:
https://doaj.org/article/c13d014cc5f94d64bb7365baef8ef77b
Autor:
Philippe Valet, Genevieéve Tavernier, Isabelle Castan-Laurell, Jean Sébastien Saulnier-Blache, Dominique Langin
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 6, Pp 835-860 (2002)
The World Health Organization has recognized obesity as a health problem of pandemic proportions. Recent work led to major breakthroughs in the understanding of the molecular basis of adipose tissue development with the cloning and characterization o
Externí odkaz:
https://doaj.org/article/708cddb37ce941e3a846f7bce1b1a57f
Autor:
Chantal Bertrand, Angelica Pignalosa, Estelle Wanecq, Chloé Rancoule, Aurélie Batut, Simon Deleruyelle, Lillà Lionetti, Philippe Valet, Isabelle Castan-Laurell
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78874 (2013)
Various studies have shown that eicosapentaenoic acid (EPA) has beneficial effects on obesity and associated disorders. Apelin, the ligand of APJ receptor also exerts insulin-sensitizing effects especially by improving muscle metabolism. EPA has been
Externí odkaz:
https://doaj.org/article/69049bb823e84070a1cd827a27d104fa
Autor:
Jean Personnaz, Enzo Piccolo, Alizée Dortignac, Jason S. Iacovoni, Jérôme Mariette, Vincent Rocher, Arnaud Polizzi, Aurélie Batut, Simon Deleruyelle, Lucas Bourdens, Océane Delos, Lucie Combes-Soia, Romain Paccoud, Elsa Moreau, Frédéric Martins, Thomas Clouaire, Fadila Benhamed, Alexandra Montagner, Walter Wahli, Robert F. Schwabe, Armelle Yart, Isabelle Castan-Laurell, Justine Bertrand-Michel, Odile Burlet-Schiltz, Catherine Postic, Pierre-Damien Denechaud, Cédric Moro, Gaelle Legube, Chih-Hao Lee, Hervé Guillou, Philippe Valet, Cédric Dray, Jean-Philippe Pradère
Publikováno v:
Science Advances
Science Advances, 2022, 8 (12), ⟨10.1126/sciadv.abg9055⟩
Science Advances, 2022, 8 (12), ⟨10.1126/sciadv.abg9055⟩
Dysregulations of lipid metabolism in the liver may trigger steatosis progression, leading to potentially severe clinical consequences such as nonalcoholic fatty liver diseases (NAFLDs). Molecular mechanisms underlying liver lipogenesis are very comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79eac556bb1af4b744201d38bffcecbf
https://hal.inrae.fr/hal-03624265/document
https://hal.inrae.fr/hal-03624265/document
Autor:
Ophélie Pereira, Jean Personnaz, Céline Saint-Laurent, Toshiyuki Araki, Maithé Tauber, Jean-Pierre Salles, Philippe Valet, Adélaïde Gélineau, Mickaël Canouil, Romain Paccoud, Armelle Yart, Jacques Weill, Jean-Philippe Pradere, Mylène Tajan, Cédric Dray, Enzo Piccolo, Sophie Le Gonidec, Inès Baba, Thomas Edouard, Emmanuel L. Gautier, Haoussa Askia, Philippe Froguel, Benjamin G. Neel, Nicolas Beton, Simon Deleruyelle, Johanna Auriau, Sophie Branka, Alizée Dortignac, Maxime Branchereau, Isabelle Castan, Christophe Heymes, Rémy Burcelin, Julie Charpentier
Publikováno v:
Science Translational Medicine
Science Translational Medicine, 2021, 13 (591), ⟨10.1126/scitranslmed.abe2587⟩
Science Translational Medicine, 2021, 13 (591), ⟨10.1126/scitranslmed.abe2587⟩
Insulin resistance is a key event in type 2 diabetes onset and a major comorbidity of obesity. It results from a combination of fat excess-triggered defects, including lipotoxicity and metaflammation, but the causal mechanisms remain difficult to ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0759a52fdb1a01c71a072f9141a84623
https://doi.org/10.1126/scitranslmed.abe2587
https://doi.org/10.1126/scitranslmed.abe2587
Autor:
Romain Paccoud, Arnaud Polizzi, Isabelle Castan-Laurell, Jérôme Mariette, Robert F. Schwabe, W. Wahli, Frédéric Martins, Jason S. Iacovoni, Enzo Piccolo, Thomas Clouaire, Simon Deleruyelle, Chih-Hao Lee, Philippe Valet, Jean-Philippe Pradere, Gaëlle Legube, Fadila Benhamed, Hervé Guillou, Alexandra Montagner, Cedric Moro, Catherine Postic, Jean Personnaz, Elsa Moreau, Cédric Dray, Alizee Dortignac, Armelle Yart, Aurélie Batut
Dysregulations of lipid metabolism in the liver may trigger steatosis progression leading to potentially severe clinical consequences such as non-alcoholic fatty liver diseases (NAFLD). Molecular mechanisms underlying liver lipogenesis are very compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52bd111c8125f84f86d0f59c23a35b9e
https://doi.org/10.1101/2021.02.17.431446
https://doi.org/10.1101/2021.02.17.431446
Publikováno v:
Molecular and cellular endocrinology. 529
Apelin, a peptide with several active isoforms ranging from 36 to 12 amino acids and its receptor APJ, a G-protein-coupled receptor, are widely distributed. However, apelin has emerged as an adipokine more than fifteen years ago, integrating the fiel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd70234aba02893b65f2a926d57ff18
https://pubmed.ncbi.nlm.nih.gov/33838166
https://pubmed.ncbi.nlm.nih.gov/33838166
Autor:
Laura M. Gosoniu, Isabel Rubio-Aliaga, Eli Gámez-Valdez, Yanelli Rodríguez-Carmona, Brianda Hernández-Morán, Ivan Montoliu, Philippe Valet, Diana C. Soria-Contreras, Diego Martínez-Conde, Ricardo Márquez-Velasco, Marisol Ramírez-Solano, Martin Kussmann, Irma Silva-Zolezzi, Mónica Ancira-Moreno, Carolina Vargas-Martinez, Aristea Binia, Rocío Gonzalez-Alberto, Rafael Bojalil, Felipe Vadillo-Ortega, Isabelle Castan, Adriana Angeles-Quezada, Carlos Pérez-Ortega, Silvia Fernández, M. Elizabeth Tejero, Juan Carlos López-Alvarenga
Publikováno v:
The Journal of Nutritional Biochemistry. 43:98-106
Polyunsaturated fatty acids (PUFA) contained in fish oil (FO) are ligands for peroxisome proliferator-activated receptors (PPAR) that may induce changes in cardiometabolic markers. Variation in PPAR genes may influence the beneficial responses linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603937824e6f6b9b966e62572bb733c9
https://doi.org/10.1016/j.jnutbio.2017.02.002
https://doi.org/10.1016/j.jnutbio.2017.02.002
Autor:
Philippe Valet, Ronan Roussel, Ray El Boustany, Ophélie Pereira, Isabelle Castan-Laurell, Louis Potier, Gilberto Velho, Pierre Gourdy, Michel Marre, Frédéric Fumeron
Publikováno v:
Diabetes care. 43(2)
Apelin is a bioactive peptide and the endogenous ligand of APJ, a G-protein–coupled receptor. It is expressed in several organs and tissues including many regions of the central nervous system and the gastrointestinal tract, the heart, the lungs, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91f7cb0e58378959d128de20e57807a
https://pubmed.ncbi.nlm.nih.gov/31806652
https://pubmed.ncbi.nlm.nih.gov/31806652
Autor:
Sophie Le Gonidec, Philippe Valet, Nancy Geoffre, Jean-Philippe Pradere, Jean Personnaz, Cedric Moro, Isabelle Castan-Laurell, C. Bertrand, Aurélie Batut, Katie Louche, Simon Deleruyelle, Bernard Masri
Publikováno v:
Endocrine
Endocrine, Springer, 2018, 60 (1), pp.112-121. ⟨10.1007/s12020-018-1536-1⟩
Endocrine, Springer, 2018, 60 (1), pp.112-121. ⟨10.1007/s12020-018-1536-1⟩
Apelin treatment has been shown to improve insulin sensitivity in insulin resistant mice by acting in skeletal muscles. However, the effects of systemic apelin on the hepatic energy metabolism have not been addressed. We thus aimed to determine the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358b1b929b79b8e4d6cdbeee9ac9afbd
https://hal.archives-ouvertes.fr/hal-02393084
https://hal.archives-ouvertes.fr/hal-02393084