The neuropeptide substance P regulates aldosterone secretion in human adrenals

Autor: Julien Wils, Céline Duparc, Anne-Françoise Cailleux, Antoine-Guy Lopez, Caroline Guiheneuf, Isabelle Boutelet, Hadrien-Gaël Boyer, Christophe Dubessy, Saloua Cherifi, Bruno Cauliez, Françoise Gobet, Guillaume Defortescu, Jean-François Ménard, Estelle Louiset, Hervé Lefebvre

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Adrenal aldosterone production is regulated by plasma angiotensin and potassium levels. Here the authors report that the neuropeptide substance P stimulates aldosterone production via neurokinin type 1 receptors (NK1R), and report a proof-of-concept

Externí odkaz: https://doaj.org/article/48ddfb7cf8b04ad380242a0ab5764f18

Dysregulation of Aldosterone Secretion in Mast Cell–Deficient Mice

Autor: Estelle Louiset, Hervé Lefebvre, Arnaud Arabo, Céline Duparc, Isabelle Boutelet, Hadrien-Gaël Boyer, Julien Wils, Sylvie Renouf

Publikováno v: Hypertension
Hypertension, American Heart Association, 2017, 70 (6), pp.1256-1263. ⟨10.1161/HYPERTENSIONAHA.117.09746⟩

Resident adrenal mast cells have been shown to activate aldosterone secretion in rat and man. Especially, mast cell proliferation has been observed in adrenal tissues from patients with aldosterone-producing adrenocortical adenoma. In the present stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a5b8db8917f22a2f077fed2d86afff
https://doi.org/10.1161/hypertensionaha.117.09746

PKA regulatory subunit 1A inactivating mutation induces serotonin signaling in primary pigmented nodular adrenal disease

Autor: Bruno Ragazzon, Isabelle Boutelet, Julien Wils, Marthe Rizk-Rabin, Estelle Louiset, Zakariae Bram, Marie-Christine Vantyghem, Rossella Libé, Sylvie Renouf, Constantine A. Stratakis, Eva Szarek, Céline Duparc, Dennis A. Carson, Antoine Martinez, Jacques Young, Hervé Lefebvre, Jérôme Bertherat

Publikováno v: JCI Insight
JCI Insight, American Society for Clinical Investigation, 2016, 1 (15), pp.e87958. ⟨10.1172/jci.insight.87958⟩
JCI Insight, 2016, 1 (15), pp.e87958. ⟨10.1172/jci.insight.87958⟩
JCI Insight, American Society for Clinical Investigation, 2016, 1 (15), ⟨10.1172/jci.insight.87958⟩

International audience; Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of ACTH-independent hypercortisolism. The disease is primarily caused by germline mutations of the protein kinase A (PKA) regulatory subunit 1A (PRKAR1A)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54122e209af72f6b75250a8b64f8281e
https://hal.archives-ouvertes.fr/hal-02108040

Gastric electrical stimulation modulates hypothalamic corticotropin-releasing factor–producing neurons during post-operative ileus in rat

Autor: Isabelle Boutelet, Sylvie Jégou, Patrice Bizet, Lourdes Mounien, Philippe Ducrotté, S. Gallas, Hubert Vaudry, Anne-Marie Leroi, Leblanc I, Guillaume Gourcerol

Publikováno v: Neuroscience. 148:775-781

High-frequency/low-energy gastric electrical stimulation (GES) is an efficient therapy to treat gastric emptying-related disorders but its mechanism of action remains poorly understood. We aimed to assess the effects of high-frequency/low-energy GES

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a288e6bc0323ed1ff5e627f6b7271f4
https://doi.org/10.1016/j.neuroscience.2007.07.001

Localization of the mRNA encoding prolyl endopeptidase in the rat brain and pituitary

Autor: Lourdes Mounien, Hubert Vaudry, Isabelle Boutelet, Gaelle Bellemère, Sylvie Jégou

Publikováno v: Journal of Comparative Neurology. 471:128-143

Prolyl endopeptidase (EC 3.4.21.26, PEP), a serine protease that hydrolyzes peptides at the carboxyl side of proline residues, is involved in the breakdown of several proline-containing neuropeptides and, thus, may contribute to the regulation of beh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5f5bcba55ae1d9a8638320f697b9549
https://doi.org/10.1002/cne.20019