Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Isabelle Berque-Bestel"'
Autor:
Michel De Méo, Carole Di Giorgio, Isabelle Berque-Bestel, Ahissan Aimé, Philippe Barthélémy, Mélanie Aye, Yves Jammes, Benoit P. Pichon
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 750:129-138
We proposed to evaluate the genotoxicity and mutagenicity of a new quantum dots (QDs) nanoplatform (QDsN), consisting of CdSe/ZnS core-shell QDs encapsulated by a natural fusogenic lipid (1,2-di-oleoyl-sn-glycero-3-phosphocholine (DOPC)) and function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c081d66416bc67d40c30ada86966b58
https://doi.org/10.1016/j.mrgentox.2012.10.010
https://doi.org/10.1016/j.mrgentox.2012.10.010
Autor:
Frank Lezoualc'h, Céline Rivière, Jean-Louis Soulier, Jean-Pierre Monti, Olivier Russo, Sames Sicsic, Marthe Cachard-Chastel, Isabelle Berque-Bestel, Tristan Richard, Mireille Giner, Magali Berthouze
Publikováno v:
Journal of Medicinal Chemistry. 52:2214-2225
Serotonin 5-HT(4) receptor (5-HT(4)R) agonists are of particular interest for the treatment of Alzheimer's disease because of their ability to ameliorate cognitive deficits and to modulate production of amyloid beta-protein (Abeta). However, despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f92df50bc84ffa6d24be4d7e4425ed
https://doi.org/10.1021/jm801327q
https://doi.org/10.1021/jm801327q
Autor:
Jean-François Peyrat, Sames Sicsic, Nathanael Olivi, Olivier Russo, Isabelle Berque-Bestel, Mouad Alami, Abdallah Hamze, Jean-Daniel Brion, Samir Messaoudi
Publikováno v:
Tetrahedron. 63:10671-10683
An efficient palladium–copper-catalyzed three-component assembling of propargyl halides, aryl or heteroaryl halides, and secondary amines is described. A wide variety of tertiary propargylic amines were synthesized in good to excellent yields from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c97ea2c6ec2ad37adc48d4ec23be78
https://doi.org/10.1016/j.tet.2007.07.096
https://doi.org/10.1016/j.tet.2007.07.096
Autor:
Johan Hoebeke, Simone Garcia, Jean-Christophe Peter, Magali Berthouze, Frank Lezoualc'h, Rehab Kamel, Pierre Eftekhari, Isabelle Berque-Bestel
Publikováno v:
Biochemical Pharmacology. 70:1009-1018
Splenocytes from a BALB/c mouse immunised with a synthetic peptide corresponding to the second extracellular loop of the 5-HT4 receptor were fused with SP2/O myeloma cells to produce a monoclonal antibody. The monoclonal antibody was of the IgG2b iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbf4a82fca2d87e71b589f9b3edd456
https://doi.org/10.1016/j.bcp.2005.07.005
https://doi.org/10.1016/j.bcp.2005.07.005
Autor:
Lucie Rivail, Bernard Maigret, Mireille Giner, Monique Gastineau, Isabelle Berque-Bestel, Frank Lezoualc'h, Sames Sicsic, Magali Berthouze, Rodolphe Fischmeister, Jean-Louis Soulier
Publikováno v:
British Journal of Pharmacology. 143:361-370
A body of evidences suggests that a hydrophobic pocket of the human 5-HT4 receptor contributes to the high affinity of some bulky 5-HT4 ligands. A thorough study of this pocket was performed using mutagenesis and molecular modeling. Ligand binding or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9db6caed5b198b1ab0daf29235e59f0a
https://doi.org/10.1038/sj.bjp.0705950
https://doi.org/10.1038/sj.bjp.0705950
Publikováno v:
Tetrahedron Letters. 45:7069-7072
A rapid and flexible synthetic approach to {[bis( tert -butoxycarbonyl)amino]propyl}piperidines 5 and related compounds is described. The key step is a three-component coupling process of 2-, 3- or 4-bromopyridine, propargyl bromide and potassium di-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfe07f40d9226ffc981d85c584bbe18
https://doi.org/10.1016/j.tetlet.2004.07.118
https://doi.org/10.1016/j.tetlet.2004.07.118
Autor:
Jeanne Mialet, Michel Langlois, Sames Sicsic, Isabelle Berque-Bestel, Frank Lezoualc'h, Rodolphe Fischmeister
Publikováno v:
British Journal of Pharmacology. 131:827-835
The recently identified C-terminal splice variant of the human 5-HT(4) receptor, the h5-HT(4(d)) receptor, was stably expressed in a CHO cell line at 493+/-25 fmol mg(-1) protein. We analysed its pharmacological properties by measuring binding affini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca4b2f00fe6bf34cb64a81615c5e395d
https://doi.org/10.1038/sj.bjp.0703641
https://doi.org/10.1038/sj.bjp.0703641
Autor:
Ivan Zahradnik, Mireille Giner, Michel Langlois, Sames Sicsic, Isabelle Berque-Bestel, Jeanne Mialet, Jean-Louis Soulier, Rodolphe Fischmeister, Frank Lezoualc'h, Sophie Curtet, Patrick Donzeau-Gouge
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2000, 43 (20), pp.3761-3769. ⟨10.1021/jm0009538⟩
Journal of Medicinal Chemistry, 2000, 43 (20), pp.3761-3769. ⟨10.1021/jm0009538⟩
International audience; New derivatives of arylpiperazine 9 were designed from ML 10302, a potent 5-HT 4 receptor agonist in the gastrointestinal system. Compounds were synthesized by condensation of a number of available arylpiperazines or heteroary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e623e3fa2d26bb562759e326bd87db
https://doi.org/10.1021/jm0009538
https://doi.org/10.1021/jm0009538
Autor:
Yamina Dahmoune, Michel Langlois, Pierre Eftekhari, Johan Hoebeke, Isabelle Berque-Bestel, Frank Lezoualc'h, Rodolphe Fischmeister, Jeanne Mialet, Sames Sicsic
Publikováno v:
British Journal of Pharmacology. 130:527-538
Among the five human 5-HT(4) (h5-HT(4)) receptor isoforms, the h5-HT(4(a)) receptor was studied with a particular emphasis on the molecular interactions involved in ligand binding. For this purpose, we used site-directed mutagenesis of the transmembr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::563cd20644129c00c35fa23822994f2a
https://doi.org/10.1038/sj.bjp.0703356
https://doi.org/10.1038/sj.bjp.0703356
Autor:
Monique Gastineau, Rodolphe Fischmeister, Patrick Donzeau-Gouge, Mireille Giner, Yamina Dahmoune, Johan Hoebeke, Pierre Eftekhari, Michel Langlois, Isabelle Berque-Bestel, Frank Lezoualc'h, Jeanne Mialet, Sames Sicsic
Publikováno v:
British Journal of Pharmacology. 129:771-781
RT–PCR technique was used to clone the human 5-HT4(e) receptor (h5-HT4(e)) from heart atrium. We showed that this h5-HT4(e) receptor splice variant is restricted to brain and heart atrium. Recombinant h5-HT4(e) receptor was stably expressed in CHO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ded86e23aadf48480158fab635fe8134
https://doi.org/10.1038/sj.bjp.0703101
https://doi.org/10.1038/sj.bjp.0703101