Výsledky vyhledávání - "Isabelle Artaud"

Akademický článek

Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria

Autor: Anas Allam, Laure Maigre, Julia Vergalli, Estelle Dumont, Bertrand Cinquin, Rodolphe Alves de Sousa, Jelena Pajovic, Elizabeth Pinet, Nikaia Smith, Jean-Philippe Herbeuval, Matthieu Réfrégiers, Isabelle Artaud, Jean-Marie Pagès

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract A main challenge in chemotherapy is to determine the in cellulo parameters modulating the drug concentration required for therapeutic action. It is absolutely urgent to understand membrane permeation and intracellular concentration of antibi

Externí odkaz: https://doaj.org/article/ca80691df79d435fac589a85f21b0920

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Akademický článek

Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases

Autor: Dominique Padovani, Assia Hessani, Francine T. Castillo, Géraldine Liot, Mireille Andriamihaja, Annaïg Lan, Camilla Pilati, François Blachier, Suvajit Sen, Erwan Galardon, Isabelle Artaud

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

High levels of homocysteine in cells are linked to pathological states. Here, the authors report that homocysteine inactivates catalase by modifying the heme group, impairing cellular redox homeostasis, and show that this modification occurs in cance

Externí odkaz: https://doaj.org/article/5c40bd245f7547b1967ae36a14dcbecc

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Akademický článek

Trapping conformational states along ligand-binding dynamics of peptide deformylase: the impact of induced fit on enzyme catalysis.

Autor: Sonia Fieulaine, Adrien Boularot, Isabelle Artaud, Michel Desmadril, Frédéric Dardel, Thierry Meinnel, Carmela Giglione

Publikováno v: PLoS Biology, Vol 9, Iss 5, p e1001066 (2011)

For several decades, molecular recognition has been considered one of the most fundamental processes in biochemistry. For enzymes, substrate binding is often coupled to conformational changes that alter the local environment of the active site to ali

Externí odkaz: https://doaj.org/article/223f520af7824a7589a2e95b485fd722

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Akademický článek

New antibiotic molecules: bypassing the membrane barrier of gram negative bacteria increases the activity of peptide deformylase inhibitors.

Autor: Laurent Mamelli, Sylvain Petit, Jacqueline Chevalier, Carmela Giglione, Aurélie Lieutaud, Thierry Meinnel, Isabelle Artaud, Jean-Marie Pagès

Publikováno v: PLoS ONE, Vol 4, Iss 7, p e6443 (2009)

BACKGROUND: Multi-drug resistant (MDR) bacteria have become a major concern in hospitals worldwide and urgently require the development of new antibacterial molecules. Peptide deformylase is an intracellular target now well-recognized for the design

Externí odkaz: https://doaj.org/article/d96febcb1a014fa5ab7ddfc7132ab1fd

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New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria

Autor: Estelle Dumont, Julia Vergalli, Rodolphe Alves de Sousa, Laure Maigre, Isabelle Artaud, Jean-Marie Pagès, Anas Allam

Publikováno v: European Journal of Medicinal Chemistry. 127:748-756

Structure of bacterial envelope is one of the major factors contributing to Gram negative bacterial resistance. To develop new agents that target the bacterial membranes, we synthesized, by analogy with our previous peptide conjugates, new amphiphili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955d6fcf2058b97f748033b0ef0cb3fc
https://doi.org/10.1016/j.ejmech.2016.10.054

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Reactions of persulfides with the heme cofactor of oxidized myoglobin and microperoxidase 11: reduction or coordination

Autor: Isabelle Artaud, Rémy Ricoux, Erwan Galardon, Florian Huguet, Dominique Padovani, Christian Herrero

Publikováno v: Dalton transactions (Cambridge, England : 2003). 46(24)

Persulfides of cysteine (CysSSH), glutathione (GSSH) or N-methoxycarbonyl-penicillamine (NAcPenSSH) react with the ferric form of myoglobin (metMb(iii)) to yield the oxy-ferrous (oxyMb(ii)) or deoxy-ferrous (deoxyMb(ii)) forms of myoglobin under aero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407c77dfa614ddeeaab3ca37ff36b3e7
https://pubmed.ncbi.nlm.nih.gov/28604868

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Corrigendum: A unique peptide deformylase platform to rationally design and challenge novel active compounds

Autor: Thierry Meinnel, Karim Hamiche, Rodolphe Alves de Sousa, Carmela Giglione, Laure Maigre, Alexis Denis, Sonia Fieulaine, Jean-Michel Bolla, Isabelle Artaud, Mickael Alimi, Abbass Taleb, Jean-Marie Pagès

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7, pp.39365. ⟨10.1038/srep39365⟩
Scientific Reports, 2017, 7, pp.39365. ⟨10.1038/srep39365⟩

Peptide deformylase (PDF) is considered an excellent target to develop antibiotics. We have performed an extensive characterization of a new PDF from the pathogen Streptococcus agalactiae, showing properties similar to other known PDFs. S. agalactiae

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57d06c00f096e2f7db1d8e48b7938f4
http://europepmc.org/articles/PMC5225600

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Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria

Autor: Laure Maigre, Jean-Marie Pagès, Anas Allam, Julia Vergalli, Jelena Pajovic, Jean-Philippe Herbeuval, Elizabeth Pinet, Nikaïa Smith, Estelle Dumont, Bertrand Cinquin, Rodolphe Alves de Sousa, Matthieu Réfrégiers, Isabelle Artaud

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7, pp.986. ⟨https://www.nature.com/articles/s41598-017-00945-8⟩. ⟨10.1038/s41598-017-00945-8⟩
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.986. ⟨10.1038/s41598-017-00945-8⟩
Scientific Reports, Nature Publishing Group, 2017, 7, pp.986. 〈https://www.nature.com/articles/s41598-017-00945-8〉. 〈10.1038/s41598-017-00945-8〉
Scientific Reports, 2017, 7 (1), pp.986. ⟨10.1038/s41598-017-00945-8⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

International audience; A main challenge in chemotherapy is to determine the in cellulo parameters modulating the drug concentration required for therapeutic action. It is absolutely urgent to understand membrane permeation and intracellular concentr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15971de99f239b702b1a57d18440529d
https://hal.archives-ouvertes.fr/hal-01511162

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A Persulfide Analogue of the Nitrosothiol SNAP: Formation, Characterization and Reactivity

Autor: Erwan Galardon, Isabelle Artaud

Publikováno v: ChemBioChem. 15:2361-2364

The proposal of the post-translational modification "S-sulfhydration" as a major pathway for H2 S-induced signaling has recently shed light on persulfides. However, the study of these species is hampered by their instability under biologically releva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba44e2ffae91abc20a9ec1914cb9199
https://doi.org/10.1002/cbic.201402312

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