Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids

Autor: Catherine Le Jossic-Corcos, Isabelle Zaghini, Paulette Bournot, Emmanuelle Logette, Celine Gonthier, Ishaiahu Shechter

Publikováno v: Biochemical Journal. 385:787-794

Dietary vegetable oils and fish oils rich in PUFA (polyunsaturated fatty acids) exert hypocholesterolaemic and hypotriglyceridaemic effects in rodents. The plasma cholesterol-lowering properties of PUFA are due partly to a diminution of cholesterol s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2611ef7c6aa4efd30271a7e0c7d0645
https://doi.org/10.1042/bj20040933

Sterol Regulatory Element-binding Protein-1c Is Responsible for Cholesterol Regulation of Ileal Bile Acid-binding Protein Gene in Vivo

Autor: Jean-François Landrier, Philippe Besnard, Stéphane Krief, Jacques Grober, Isabelle Zaghini, Michael A. Watson, Jon L. Collins, Isabelle Lefrère, Stacey A. Jones, Hiroshi Fujii, Marie-Claude Monnot

Publikováno v: Journal of Biological Chemistry. 277:1324-1331

Ileal bile acid-binding protein (I-BABP) is a cytosolic protein that binds bile acid (BA) specifically. In the ileum, it is thought to be implied in their enterohepatic circulation. Because the fecal excretion of BA represents the main physiological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff92a3a1fb163599e25ea2f39c877940
https://doi.org/10.1074/jbc.m106375200

The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors

Autor: Hélène Poirier, Valerie Petit, Isabelle Zaghini, Jean-François Landrier, Philippe Besnard, Isabelle Niot, Charles Thomas, Jacques Grober

Publikováno v: Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, Elsevier, 2005, 1735 (1), pp.41-49. ⟨10.1016/j.bbalip.2005.05.002⟩

International audience; Peroxisome proliferator-activator receptors (PPAR) are involved in cholesterol homeostasis through the regulation of bile acids synthesis, composition, and reclamation. As ileal bile acid-binding protein (I-BABP) is thought to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e9a0745b006a2b03f43f5ad3d7ec74
https://pubmed.ncbi.nlm.nih.gov/15936983

Regulation of Farnesyl Diphosphate Synthase Gene Expression by Fatty Acids

Autor: Isabelle Zaghini, Catherine Le Jossic-Corcos, Emmanuelle Logette, Celine Gonthier, Paulette Bournot

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781461347828

Cholesterol biosynthesis depends on the activity of regulatory enzymes, including the peroxisomal Farnesyl Diphosphate Synthase (FPPS ). Cholesterol regulates its own synthesis rate. Hence, as a response to cholesterol depletion, a feed back mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c08de452456cb1589e45f383754113b5
https://doi.org/10.1007/978-1-4419-9072-3_44

Regulation of the ileal bile acid-binding protein gene: An approach to determine its physiological function(s)

Autor: Jean-François, Landrier, Jacques, Grober, Isabelle, Zaghini, Philippe, Besnard

Publikováno v: Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry, Springer Verlag, 2002, 239 (1/2), pp.149-155. ⟨10.1023/A:1020557502795⟩

International audience; Ileal bile acid-binding protein (I-BABP) is a soluble bile acids (BA) carrier protein which belongs to the fatty acid-binding protein (FABP) family. In the gut, its expression is strictly restricted to the ileum, where it is t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::47c6b4ac35c6f2952680ccf15783f6ab
https://hal-agrosup-dijon.archives-ouvertes.fr/hal-01959865