Soluble oligomers of amyloid-β peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway

Autor: Catherine Malaplate-Armand, Sabrina Florent-Béchard, Ihsen Youssef, Violette Koziel, Isabelle Sponne, Badreddine Kriem, Brigitte Leininger-Muller, Jean-Luc Olivier, Thierry Oster, Thierry Pillot

Publikováno v: Neurobiology of Disease, Vol 23, Iss 1, Pp 178-189 (2006)

Recent data have revealed that soluble oligomeric amyloid-β peptide (Aβ) may be the proximate effectors of neuronal injuries and death in Alzheimer's disease (AD) by unknown mechanisms. Consistently, we recently demonstrated the critical role of a

Externí odkaz: https://doaj.org/article/d39b60c70c3c435ca2fdf52573504b39

Activation of T cells by dendritic cells exposed to a reference sensitizer Towards a promising model to assess the allergenic potential of chemicals

Autor: Fabrice Battais, Isabelle Sponne, Isabelle Langonné, F. Gagnaire, Christophe Paris, Julianne Mathiot, Hakima Abdessadeq, Samuel Muller, Cécile Huppert

Publikováno v: Contact Dermatitis
Contact Dermatitis, Wiley, 2018, 79 (2), pp.67-75. ⟨10.1111/cod.12991⟩
Contact Dermatitis, 2018, 79 (2), pp.67-75. ⟨10.1111/cod.12991⟩

International audience; Background - Low molecular weight chemicals constitute one of the major causes of occupational allergies. European legislation on chemicals recommends limiting the use of in vivo models for assessing the sensitizing potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23d65fb194d3c6a59a8d7ee9ec56327
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01795806

Evaluation of chromium in red blood cells as an indicator of exposure to hexavalent chromium: An in vitro study

Autor: Samuel Muller, Antoine Géhin, Isabelle Sponne, Mathieu Melczer, Guillaume Antoine, Jérôme Devoy, Aurélie Remy

Publikováno v: Toxicology Letters
Toxicology Letters, Elsevier, 2016, 255, pp.63-70. ⟨10.1016/j.toxlet.2016.05.008⟩
Toxicology Letters, 2016, 255, pp.63-70. ⟨10.1016/j.toxlet.2016.05.008⟩

International audience; Chromium(VI) compounds are classified as carcinogenic to humans. Whereas chromium measurements in urine and whole blood (i.e., including plasma) are indicative of recent exposure, chromium in red blood cells (RBC) is attributa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566a69b9efdd2bd35db50c4e5c8569f6
https://hal.archives-ouvertes.fr/hal-03038111

Humanin rescues cortical neurons from prion-peptide-induced apoptosis

Autor: Thierry Oster, Alexandre Fifre, Badreddine Kriem, Violette Koziel, Isabelle Sponne, Thierry Pillot

Publikováno v: Molecular and Cellular Neuroscience. 25:95-102

We recently demonstrated that a soluble oligomeric prion peptide, the putative 118–135 transmembrane domain of prion protein (PrP), exhibited membrane fusogenic properties and induced apoptotic cell death both in vitro and in vivo. A recently disco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8806f7025ec392b97a44371bca1cd2da
https://doi.org/10.1016/j.mcn.2003.09.017

Cytosolic phospholipase A2mediates neuronal apoptosis induced by soluble oligomers of the amyloid‐β peptide

Autor: Jean-Luc Olivier, Frances Yen-Potin, Violette Koziel, Thierry Oster, Alexandre Fifre, Bernard Bihain, Catherine Malaplate-Armand, Thierry Pillot, Isabelle Sponne, Karine Lozac'h-Pillot, Badreddine Kriem

Publikováno v: The FASEB Journal. 19:85-87

Recent data have revealed that soluble oligomeric forms of amyloid peptide (Abeta) may be the proximate effectors of the neuronal injury and death occurring in Alzheimer's disease (AD). However, the molecular mechanisms associated with the neuronal c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4e278e395a3727a6de4f0acc29eec0
https://doi.org/10.1096/fj.04-1807fje