Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Isabelle, Margaill"'
Autor:
Julia Jolibois, Alison Domingues, Divina El Hamaoui, Raphaël Awaida, Mathilde Berger-de-Gaillardo, Daniel Guérin, David M Smadja, Perrine Marquet-DeRougé, Isabelle Margaill, Elisa Rossi, Valérie Nivet-Antoine
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background This study explores the potential role of Thioredoxin-interacting protein (TXNIP) silencing in endothelial colony-forming cells (ECFCs) within the scope of age-related comorbidities and impaired vascular repair. We aim to elucidat
Externí odkaz:
https://doaj.org/article/23f9a1a27f634f52abc59e9518de0b30
Autor:
Clément Delage, Nicolas Vignal, Coralie Guerin, Toufik Taib, Clément Barboteau, Célia Mamma, Kahina Khacef, Isabelle Margaill, Laure Sarda-Mantel, Nathalie Rizzo-Padoin, Fortune Hontonnou, Catherine Marchand-Leroux, Dominique Lerouet, Benoit Hosten, Valérie Besson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Traumatic brain injury (TBI) leads to a deleterious neuroinflammation, originating from microglial activation. Monitoring microglial activation is an indispensable step to develop therapeutic strategies for TBI. In this study, we evaluated t
Externí odkaz:
https://doaj.org/article/e9e296322b2849199b75c33bbdb47dda
Autor:
Elisa Rossi, Miguel Pericacho, Alexandre Kauskot, Luis Gamella-Pozuelo, Etienne Reboul, Alexandre Leuci, Cristina Egido-Turrion, Divina El Hamaoui, Aurore Marchelli, Francisco J. Fernández, Isabelle Margaill, M. Cristina Vega, Pascale Gaussem, Samuela Pasquali, David M. Smadja, Christilla Bachelot-Loza, Carmelo Bernabeu
Publikováno v:
Journal of Thrombosis and Haemostasis.
14 p.-6 fig.
Background: The circulating form of human endoglin (sEng) is a cleavage product of membrane-bound endoglin present on endothelial cells. Because sEng encompasses an RGD motif involved in integrin binding, we hypothesized that sEng w
Background: The circulating form of human endoglin (sEng) is a cleavage product of membrane-bound endoglin present on endothelial cells. Because sEng encompasses an RGD motif involved in integrin binding, we hypothesized that sEng w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e56f7db1317043814ece34e2e5be79
https://doi.org/10.1016/j.jtha.2023.03.023
https://doi.org/10.1016/j.jtha.2023.03.023
Autor:
Victor Baldim, Jean-François Berret, Cédric Loubat, Geoffroy Goujon, Caroline Roques, Nathalie Mignet, Alain Graillot, Nicolas Bia, Isabelle Margaill, Bruno Palmier, Johanne Seguin, Virginie Beray-Berthat
Publikováno v:
Advanced Healthcare Materials
Advanced Healthcare Materials, Wiley, 2021, 10 (11), pp.2100059. ⟨10.1002/adhm.202100059⟩
Advanced Healthcare Materials, Wiley, 2021, 10 (11), pp.2100059. ⟨10.1002/adhm.202100059⟩
Oxidative stress, which is one of the main harmful mechanisms of pathologies including is-chemic stroke, contributes to both neurons and endothelial cell damages, leading to vascular lesions. Although many antioxidants have been tested in preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246640932de7fc5861ac7530515e030e
http://arxiv.org/abs/2104.03005
http://arxiv.org/abs/2104.03005
Autor:
Jean-François Ghersi-Egea, Mathieu Santin, Christiane Charriaut-Marlangue, Mickael Tanter, Fabienne Glacial, Luigi Titomanlio, Stéphane Lehéricy, Zsolt Csaba, Charlie Demene, Pierre-Louis Leger, Pascal Dournaud, Bérard Coqueran, Stéphane Auvin, Iolanda Parente, Alice Jacquens, Isabelle Margaill, Homa Adle-Biassette, Jean-François Aubry, Pierre Gressens, Charlotte Constans, Nicolas Perrière, Tania Vitalis
Publikováno v:
Neuropathology and Applied Neurobiology
Neuropathology and Applied Neurobiology, 2021, 47 (2), pp.297-315. ⟨10.1111/nan.12665⟩
Neuropathology and Applied Neurobiology, 2021, 47 (2), pp.297-315. ⟨10.1111/nan.12665⟩
We introduce a novel approach based on agonist‐induced internalization of a neuronal G protein‐coupled receptor widely distributed in the mammalian brain, the somatostatin receptor type 2 (SST2).This approach provides an alternative and simple ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cf08e65f5f6f615d024a87931ccdae
https://hal.science/hal-03818501
https://hal.science/hal-03818501
Autor:
Marie Lechaftois, Elise Dreano, Bruno Palmier, Isabelle Margaill, Catherine Marchand-Leroux, Christilla Bachelot-Loza, Dominique Lerouet
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110776 (2014)
BACKGROUND: Neuro- and vasoprotective effects of poly(ADP-ribose)polymerase (PARP) inhibition have been largely documented in models of cerebral ischemia, particularly with the potent PARP inhibitor PJ34. Furthermore, after ischemic stroke, physician
Externí odkaz:
https://doaj.org/article/9d744c3f5f7e4540a9844ea368effbfc
Autor:
Jean-Jacques Parienti, Stephen Meairs, Mohamad El Amki, Maxime Gauberti, Marc Fatar, Isabelle Margaill, Benoit Haelewyn, Richard Macrez, Josune Orbe, Denis Vivien, Alan R. Young, Saema Ansar, Marina Rubio, Emmanuel Touzé, Samaneh Maysami, Nancy J. Rothwell, Ignacio Lizasoain, Stuart M. Allan, Christian Waeber, T.-H. Cho, Eng H. Lo, Francesco Campos, Anne Durand, José A. Páramo, Isaac García-Yébenes, Norbert Nighoghossian, Saskia Grudzenski, Cyrille Orset
Publikováno v:
University of Manchester-PURE
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Background and Purpose— The debate over the fact that experimental drugs proposed for the treatment of stroke fail in the translation to the clinical situation has attracted considerable attention in the literature. In this context, we present a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1c0dda79f6f6b1344afed2c2cf104a
https://doi.org/10.1161/strokeaha.116.012238
https://doi.org/10.1161/strokeaha.116.012238
Publikováno v:
Behavioural brain research. 360
Efforts are still needed regarding the research of therapeutics for ischemic stroke. While in experimental studies the protective effect of pharmacological agents is often highlighted by a reduction of the lesion size evaluated in the short term (day
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40fd721a3606b6852cf29d42b0ca3b4
https://pubmed.ncbi.nlm.nih.gov/30500429
https://pubmed.ncbi.nlm.nih.gov/30500429
Autor:
Bruno Palmier, Dominique Lerouet, Benoît Barsacq, Charlotte Abbou, Bérard Coqueran, Isabelle Margaill, Catherine Marchand-Leroux, Virginie Beray-Berthat, Mohamad El Amki, Fei Teng, Marie Garraud
Publikováno v:
Molecular neurobiology. 55(12)
Benefits from thrombolysis with recombinant tissue plasminogen activator (rt-PA) after ischemic stroke remain limited due to a narrow therapeutic window, low reperfusion rates, and increased risk of hemorrhagic transformations (HT). Experimental data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4789f8a4190e7334e692b3d90170d04
https://pubmed.ncbi.nlm.nih.gov/29651748
https://pubmed.ncbi.nlm.nih.gov/29651748
Publikováno v:
Nanoscale
Nanoscale, Royal Society of Chemistry, 2018, 10 (15), pp.6971-6980. ⟨10.1039/C8NR00325D⟩
Nanoscale, Royal Society of Chemistry, 2018, 10 (15), pp.6971-6980. ⟨10.1039/c8nr00325d⟩
Nanoscale, 2018, 10 (15), pp.6971-6980. ⟨10.1039/C8NR00325D⟩
Nanoscale, Royal Society of Chemistry, 2018, 10 (15), pp.6971-6980. ⟨10.1039/C8NR00325D⟩
Nanoscale, Royal Society of Chemistry, 2018, 10 (15), pp.6971-6980. ⟨10.1039/c8nr00325d⟩
Nanoscale, 2018, 10 (15), pp.6971-6980. ⟨10.1039/C8NR00325D⟩
Cerium oxide nanoparticles are known to catalyze the decomposition of reactive oxygen species such as superoxide radical and hydrogen peroxide. Herein, we examine the superoxide dismutase (SOD) and catalase (CAT) mimetic catalytic activities of nanoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b4d59a386657abf82e324496070a7c
https://hal.archives-ouvertes.fr/hal-02342481
https://hal.archives-ouvertes.fr/hal-02342481