Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Isabelle, Hainault"'
Autor:
Isabelle Hainault, N. Semiane, Fabienne Foufelle, Ali Khalkhal, Pascal Ferré, A. Mallek, Souad Ameddah, Y. Dahmani
Publikováno v:
Comptes Rendus Biologies. 340:25-36
A high intake of sugars has been linked to diet-induced health problems. The aim of this study was to assess whether the long-term consumption of a high-carbohydrate diet (HCD) would cause the hepatic histopathological and metabolic abnormalities tha
Autor:
Hervé Le Stunff, Kelly Meneyrol, Nadim Kassis, Mark Ibberson, Julien Véret, Christophe Magnan, Lara Bellini, Isabelle Hainault, Jessica Denom, Céline Cruciani-Guglielmacci, Véronique Lenoir, Piero Marchetti, Agnieszka Blachnio-Zabielska, Mélanie Campana, Marta Chacinska, Carina Prip-Buus, Marco Bugliani, Bernard Thorens, Claude Rouch
Publikováno v:
Diabetologia
Diabetologia, Springer Verlag, 2018, 61 (8), pp.1780-1793. ⟨10.1007/s00125-018-4629-8⟩
Diabetologia, Springer Verlag, 2018, 61 (8), pp.1780-1793. ⟨10.1007/s00125-018-4629-8⟩
Dietary n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), are known to influence glucose homeostasis. We recently showed that Elovl2 expression in beta cells, which regulates synthesis of endogenous DHA, was associated with gluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9342f430169159099cb0c2b14924ed
https://hal.archives-ouvertes.fr/hal-02122657
https://hal.archives-ouvertes.fr/hal-02122657
Autor:
Isabelle Dugail, Nemanja Vujic, Paul Dasilva-Jardine, Andrea E. Bochem, Kees Hovingh, Emmanuel L. Gautier, Fabienne Foufelle, Thibault Barouillet, François Orange, Madalina Duta-Mare, Manon Viaud, Laurent Yvan-Charvet, Lazaro Emilio Aira, Laurent Boyer, Christian Stehlik, Sandrine Marchetti, Edward B. Thorp, Stoyan Ivanov, Elsa Garcia, Dagmar Kratky, Rodolphe Guinamard, Isabelle Hainault
Publikováno v:
Circulation Research
Circulation Research, American Heart Association, 2018, 122 (10), pp.1369-1384. ⟨10.1161/circresaha.117.312333⟩
Circulation Research, American Heart Association, 2018, 122 (10), pp.1369-1384. ⟨10.1161/circresaha.117.312333⟩
Rationale: Macrophages face a substantial amount of cholesterol after the ingestion of apoptotic cells, and the LIPA (lysosomal acid lipase) has a major role in hydrolyzing cholesteryl esters in the endocytic compartment. Objective: Here, we directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cfb224079933872747e3033b5a053f0
https://europepmc.org/articles/PMC6034181/
https://europepmc.org/articles/PMC6034181/
Autor:
Catherine Bernard, Aurélie Carlier, Anne-Françoise Batto, Fabienne Foufelle, Olivier Bourron, Nicolas Venteclef, Anaïs Szpigel, Isabelle Hainault, Pascal Ferré, Eric Hajduch, Alain Ktorza, Jean-François Gautier
Publikováno v:
Diabetologia
Diabetologia, Springer Verlag, 2018, 61 (2), pp.399-412. ⟨10.1007/s00125-017-4462-5⟩
Diabetologia, Springer Verlag, 2018, 61 (2), pp.399-412. ⟨10.1007/s00125-017-4462-5⟩
Obesity and type 2 diabetes are concomitant with low-grade inflammation affecting insulin sensitivity and insulin secretion. Recently, the thioredoxin interacting protein (TXNIP) has been implicated in the activation process of the NOD-like receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4700a3d28472f0e1d138e0ef6ad23d
https://hal.archives-ouvertes.fr/hal-02450833
https://hal.archives-ouvertes.fr/hal-02450833
Autor:
Marie-Françoise Arthus, Lise Bankir, Daniel G. Bichet, Sofia Enhörning, Dorinne Desposito, Olle Melander, Ronan Roussel, Catherine Chollet, Valérie Paradis, Christophe Magnan, Christopher Taveau, Isabelle Hainault, Nadine Bouby, Ludovic Waeckel, Erwann Philippe, Gilberto Velho, Fabienne Foufelle
Publikováno v:
Diabetologia. 58:1081-1090
High plasma copeptin, a marker of vasopressin (VP) secretion, has been shown to be associated with the metabolic syndrome and development of type 2 diabetes in humans. The present study was designed to determine the long-term influence of plasma VP c
Autor:
Laurent Boyer, Laurent Yvan-Charvet, Andrea E. Bochem, Sandrine Marchetti, Madalina Duta-Mare, Manon Viaud, Kees Hovingh, Christian Stehlik, Isabelle Hainault, Emmanuel L. Gautier, Fabienne Foufelle, Rodolphe Guinamard, Dagmar Kratky, Stoyan Ivanov, Nemanja Vujic, Isabelle Dugail, Edward B. Thorp
Publikováno v:
Atherosclerosis. 287:e77
Publikováno v:
Journal of Molecular Biology
Journal of Molecular Biology, 2016, Journal of Molecular Biology, 428 (16), pp.3295-3304. ⟨10.1016/j.jmb.2016.04.035⟩
Journal of Molecular Biology, 2016, Journal of Molecular Biology, 428 (16), pp.3295-3304. ⟨10.1016/j.jmb.2016.04.035⟩
International audience; Liver Fatty Acid Synthase (FAS) is pivotal for de novo lipogenesis. Loss of control of this metabolic pathway contributes to the development of liver pathologies ranging from steatosis to nonalcoholic steatohepatitis (NASH) wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f55833e80faa2f24ab7a439948f01e
https://hal.univ-lille.fr/hal-03285077
https://hal.univ-lille.fr/hal-03285077
Autor:
Rongrong Fan, Toby Lawrence, Judith Aron-Wisnewsky, Fabienne Foufelle, Zhiqiang Huang, Patricia Ancel, Anastasios E. Damdimopoulos, Antoine Soprani, Isabelle Hainault, Ning Liang, Saioa Goñi, Raphaelle Ballaire, Jean-François Gautier, Amine Toubal, Karima Drareni, Fawaz Alzaid, Eckardt Treuter, Nicolas Venteclef
Publikováno v:
Nature Medicine
Nature Medicine, 2016, 22 (7), pp.780-791. ⟨10.1038/nm.4114⟩
Nature Medicine, Nature Publishing Group, 2016, 22 (7), pp.780-791. ⟨10.1038/nm.4114⟩
Nature Medicine, 2016, 22 (7), pp.780-791. ⟨10.1038/nm.4114⟩
Nature Medicine, Nature Publishing Group, 2016, 22 (7), pp.780-791. ⟨10.1038/nm.4114⟩
International audience; Humans with obesity differ in their susceptibility to developing insulin resistance and type 2 diabetes (T2D). This variation may relate to the extent of adipose tissue (AT) inflammation that develops as their obesity progress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1fae84484ad3da68e69f3aa0019635
https://hal.science/hal-01438151
https://hal.science/hal-01438151
Autor:
Fabien Koskas, Eric Hajduch, Rima Hage Hassan, Fabienne Foufelle, Ana Catarina Pacheco de Sousa, Olivier Bourron, Isabelle Hainault, Pascal Ferré, Rana Mahfouz, Agnieszka Blachnio-Zabielska, Jan Górski
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (6), pp.3019-3029. ⟨10.1074/jbc.M115.686949⟩
Journal of Biological Chemistry, 2016, 291 (6), pp.3019-3029. ⟨10.1074/jbc.M115.686949⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (6), pp.3019-3029. 〈10.1074/jbc.M115.686949〉
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (6), pp.3019-3029. ⟨10.1074/jbc.M115.686949⟩
Journal of Biological Chemistry, 2016, 291 (6), pp.3019-3029. ⟨10.1074/jbc.M115.686949⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (6), pp.3019-3029. 〈10.1074/jbc.M115.686949〉
International audience; In vivo, ectopic accumulation of fatty acids in muscles leads to alterations in insulin signaling at both the IRS1 and Akt steps. However, in vitro treatments with saturated fatty acids or their derivative ceramide demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdc489ef43ffa7198a6780d658db366
https://europepmc.org/articles/PMC4742763/
https://europepmc.org/articles/PMC4742763/
Publikováno v:
Current Opinion in Lipidology. 21:239-246
Purpose of review To examine the role of endoplasmic reticulum stress in the regulation of hepatic lipid metabolism and its contribution to the development of hepatic steatosis. Recent findings Endoplasmic reticulum stress activation has been reporte