Validation of Liquid Chromatography Coupled with Tandem Mass Spectrometry for the Determination of 12 Tyrosine Kinase Inhibitors (TKIs) and Their Application to Therapeutic Drug Monitoring in Adult and Pediatric Populations

Autor: Marie Bellouard, Jean Donadieu, Pauline Thiebot, Etienne Giroux Leprieur, Philippe Saiag, Isabelle Etting, Pamela Dugues, Emuri Abe, Jean-Claude Alvarez, Islam-Amine Larabi

Publikováno v: Pharmaceutics, Vol 16, Iss 1, p 5 (2023)

Tyrosine kinase inhibitors (TKIs) are used as targeted cancer therapies in adults and have an off-label pediatric application for the treatment of Langerhans cell histiocytosis. A multitarget LC-MS/MS method was developed and validated for the determ

Externí odkaz: https://doaj.org/article/4652bf71bb0b4d0eaf12ccc05c0b7f90

Population Pharmacokinetics of Hydroxychloroquine and 3 Metabolites in COVID-19 Patients and Pharmacokinetic/Pharmacodynamic Application

Autor: Jean Claude Alvarez, Benjamin Davido, Pierre Moine, Isabelle Etting, Djillali Annane, Islam Amine Larabi, Nicolas Simon

Publikováno v: Pharmaceuticals, Vol 15, Iss 2, p 256 (2022)

We develop a population pharmacokinetic model for hydroxychloroquine (HCQ) and three of its metabolites (desethylhydroxychloroquine, Des HCQ; desethylchloroquine, DesCQ; and didesethylchloroquine, didesCQ) in COVID-19 patients in order to determine w

Externí odkaz: https://doaj.org/article/e757316a025c4bd8a27855ca745d5934

Étude de cas : interprétation des concentrations de CBD-COOH et de THC-COOH dans l’urine et des concentrations capillaires de CBD et de THC après la consommation de produits à base de CBD

Autor: Islam Amine Larabi, Emuri Abe, Yann Barguil, Isabelle Etting, Véronique Le Bihan, Ingrid Fuss-Ohlen, Jean-Claude Alvarez

Publikováno v: Toxicologie Analytique et Clinique. 35:S26-S27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15776ddbea3af34924f435e736637fb1
https://doi.org/10.1016/j.toxac.2023.03.034

Intranasal (R, S)-ketamine delivery induces sustained antidepressant effects associated with changes in cortical balance of excitatory/inhibitory synaptic activity

Autor: Thi Mai Loan Nguyen, Céline Defaix, Indira Mendez-David, Laurent Tritschler, Isabelle Etting, Jean-Claude Alvarez, Walid Choucha, Romain Colle, Emmanuelle Corruble, Denis J. David, Alain M. Gardier

Publikováno v: Neuropharmacology. 225

In 2019, an intranasal (IN) spray of esketamine SPRAVATO® was approved as a fast-acting antidepressant by drug Agencies US FDA and European EMA. At sub-anesthetic doses, (±)-ketamine, a non-competitive glutamate N-methyl-d-aspartate (NMDA) receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af92fbf36f39df0042492a61a110134e
https://pubmed.ncbi.nlm.nih.gov/36462636

Quantification of plasma remdesivir and its metabolite GS-441524 using liquid chromatography coupled to tandem mass spectrometry. Application to a Covid-19 treated patient

Autor: Islam Amine Larabi, Jean-Claude Alvarez, Isabelle Etting, P Moine, Djillali Annane

Publikováno v: Clinical Chemistry and Laboratory Medicine
Clinical Chemistry and Laboratory Medicine, De Gruyter, 2020, 58 (9), pp.1461-1468. ⟨10.1515/cclm-2020-0612⟩

Objectives A method based on liquid chromatography coupled to triple quadrupole mass spectrometry detection using 50 µL of plasma was developed and fully validated for quantification of remdesivir and its active metabolites GS-441524. Methods A simp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2417d9846da538927d7283bf3c9c063
https://doi.org/10.1515/cclm-2020-0612