Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Isabelle, Deschênes"'
Publikováno v:
Heart Rhythm O2, Vol 2, Iss 1, Pp 89-106 (2021)
Long QT syndrome (LQTS) is a cardiovascular disorder characterized by an abnormality in cardiac repolarization leading to a prolonged QT interval and T-wave irregularities on the surface electrocardiogram. It is commonly associated with syncope, seiz
Externí odkaz:
https://doaj.org/article/da2c0da0c9c84ee0bd50a05238920366
Autor:
Alain Meyer, Yves Troyanov, Julie Drouin, Geneviève Oligny-Longpré, Océane Landon-Cardinal, Sabrina Hoa, Baptiste Hervier, Josiane Bourré-Tessier, Anne-Marie Mansour, Sara Hussein, Vincent Morin, Eric Rich, Jean-Richard Goulet, Sandra Chartrand, Marie Hudson, Jessica Nehme, Jean-Paul Makhzoum, Farah Zarka, Edith Villeneuve, Jean-Pierre Raynauld, Marianne Landry, Erin K. O’Ferrall, Jose Ferreira, Benjamin Ellezam, Jason Karamchandani, Sandrine Larue, Rami Massie, Catherine Isabelle, Isabelle Deschênes, Valérie Leclair, Hélène Couture, Ira N. Targoff, Marvin J. Fritzler, Jean-Luc Senécal
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-10 (2020)
Abstract Objective To describe successful therapeutic strategies in statin-induced anti-HMGCR myopathy. Methods Retrospective data from a cohort of 55 patients with statin-induced anti-HMGCR myopathy, sequentially stratified by the presence of proxim
Externí odkaz:
https://doaj.org/article/7cd542ee442d4d3e8caaecafd505f1e6
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 7, p 209 (2022)
Background: Pathogenic variants in SCN5A, the gene encoding the cardiac Na+ channel α-subunit Nav1.5, result in life-threatening arrhythmias, e.g., Brugada syndrome, cardiac conduction defects and long QT syndrome. This variety of phenotypes is unde
Externí odkaz:
https://doaj.org/article/dffc1b2ef2304cd78a17f218e879a0a2
Autor:
Yang Zheng, Xiaoping Wan, Dandan Yang, Angelina Ramirez-Navarro, Haiyan Liu, Ji-Dong Fu, Isabelle Deschênes
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Nav1.5, encoded by the gene SCN5A, is the predominant voltage-gated sodium channel expressed in the heart. It initiates the cardiac action potential and thus is crucial for normal heart rhythm and function. Dysfunctions in Nav1.5 have been involved i
Externí odkaz:
https://doaj.org/article/6c486a91cdbd402ea3d8c7514304b5fd
Autor:
Yang Zheng, Isabelle Deschênes
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 384:417-428
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68d35991c6cde7826ba21bd32f53babd
https://doi.org/10.1124/jpet.122.001407
https://doi.org/10.1124/jpet.122.001407
Autor:
Jérôme Clatot, Malcolm Hoshi, Xiaoping Wan, Haiyan Liu, Ankur Jain, Krekwit Shinlapawittayatorn, Céline Marionneau, Eckhard Ficker, Taekjip Ha, Isabelle Deschênes
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that
Externí odkaz:
https://doaj.org/article/85a3e4c0115748e58575917074c2df76
Autor:
Emre Bektik, Yu Sun, Adrienne T. Dennis, Phraew Sakon, Dandan Yang, Isabelle Deschênes, Ji-Dong Fu
Publikováno v:
Cells, Vol 10, Iss 7, p 1572 (2021)
Direct cardiac reprogramming of fibroblasts into induced cardiomyocytes (iCMs) is a promising approach but remains a challenge in heart regeneration. Efforts have focused on improving the efficiency by understanding fundamental mechanisms. One major
Externí odkaz:
https://doaj.org/article/4e5d54f129724173b8d171571811c858
Publikováno v:
HeartRhythm Case Reports, Vol 1, Iss 4, Pp 201-205 (2015)
Externí odkaz:
https://doaj.org/article/5ccba276c3d547a6afe35bd9b8c54a00
Autor:
Drew M Nassal, Xiaoping Wan, Haiyan Liu, Danielle Maleski, Angelina Ramirez-Navarro, Christine S Moravec, Eckhard Ficker, Kenneth R Laurita, Isabelle Deschênes
Publikováno v:
eLife, Vol 6 (2017)
Arrhythmogenesis from aberrant electrical remodeling is a primary cause of death among patients with heart disease. Amongst a multitude of remodeling events, reduced expression of the ion channel subunit KChIP2 is consistently observed in numerous ca
Externí odkaz:
https://doaj.org/article/b6bb4391289341408afd11106adb8d98
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175221 (2017)
Pathologic electrical remodeling and attenuated cardiac contractility are featured characteristics of heart failure. Coinciding with these remodeling events is a loss of the K+ channel interacting protein, KChIP2. While, KChIP2 enhances the expressio
Externí odkaz:
https://doaj.org/article/3ff4d10bb9084f508ca5ac147be2f19d