Zobrazeno 1 - 10
of 366
pro vyhledávání: '"Isabelle, Coppens"'
Autor:
Daniel N. A. Tagoe, Adeline Ribeiro E Silva, Allison A. Drozda, Isabelle Coppens, Bradley I. Coleman, Marc-Jan Gubbels
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Toxoplasma gondii is a polarized cell concentrating several secretory organelles at the apical pole. The secretory micronemes come in two sub-populations differentiated by dependence on Rab5A/C in their biogenesis. Calcium-dependent exocytos
Externí odkaz:
https://doaj.org/article/fc639464081047ac9014821ef1bcb5d6
Autor:
Justin J Quan, Lachezar A Nikolov, Jihui Sha, James A Wohlschlegel, Isabelle Coppens, Peter J Bradley
Publikováno v:
PLoS Biology, Vol 22, Iss 5, p e3002634 (2024)
Toxoplasma gondii resides in its intracellular niche by employing a series of specialized secretory organelles that play roles in invasion, host cell manipulation, and parasite replication. Rab GTPases are major regulators of the parasite's secretory
Externí odkaz:
https://doaj.org/article/dbb35b1607234583827f4608b83c533c
Autor:
Patricia Silvia Romano, Takahiko Akematsu, Sébastien Besteiro, Annina Bindschedler, Vern B. Carruthers, Zeinab Chahine, Isabelle Coppens, Albert Descoteaux, Thabata Lopes Alberto Duque, Cynthia Y. He, Volker Heussler, Karine G. Le Roch, Feng-Jun Li, Juliana Perrone Bezerra de Menezes, Rubem Figueiredo Sadok Menna-Barreto, Jeremy C. Mottram, Jacqueline Schmuckli-Maurer, Boris Turk, Patricia Sampaio Tavares Veras, Betiana Nebai Salassa, María Cristina Vanrell
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
Pathogenic protists are a group of organisms responsible for causing a variety of human diseases including malaria, sleeping sickness, Chagas disease, leishmaniasis, and toxoplasmosis, among others. These diseases, which affect more than one billion
Externí odkaz:
https://doaj.org/article/db36491097774e2e9ebb756ffacb1e38
Autor:
Beejan Asady, Vera Sampels, Julia D Romano, Jelena Levitskaya, Bao Lige, Pratik Khare, Anne Le, Isabelle Coppens
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011566 (2023)
As an obligate intracellular parasite, Toxoplasma gondii must import essential nutrients from the host cell into the parasitophorous vacuole. We previously reported that the parasite scavenges cholesterol from host endocytic organelles for incorporat
Externí odkaz:
https://doaj.org/article/83cd0b2bfb51466b98d2a337375a39fa
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT Toxoplasma gondii is an obligate, intracellular parasite. Infection of a cell produces a unique niche for the parasite named the parasitophorous vacuole (PV) initially composed of host plasma membrane invaginated during invasion. The PV and
Externí odkaz:
https://doaj.org/article/76db4ae80b0b4c5097d89e961faf15b8
Autor:
Zhu-Hong Li, Thayer P. King, Lawrence Ayong, Beejan Asady, Xinjiang Cai, Taufiq Rahman, Stephen A. Vella, Isabelle Coppens, Sandip Patel, Silvia N. J. Moreno
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Two-pore channels (TPCs) are cation channels that localize to acidic organelles to regulate Ca2+ dependent events. Here, Li et al. characterize a TPC from Toxoplasma gondii(TgTPC) that localizes to the apicoplast, is critical for maintaining its inte
Externí odkaz:
https://doaj.org/article/40af680df6674080819ee06c0c3a8c98
Autor:
Tejram Sahu, Ella J. Gehrke, Yevel Flores-Garcia, Godfree Mlambo, Julia D. Romano, Isabelle Coppens
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-15 (2021)
Abstract Genetically attenuated sporozoite vaccines can elicit long-lasting protection against malaria but pose risks of breakthrough infection. Chemoprophylaxis vaccination (CVac) has proven to be the most effective vaccine strategy against malaria.
Externí odkaz:
https://doaj.org/article/432db3d909be41fbba6bddb8eb40f52c
Autor:
María Eugenia Cortina, R Clayton Bishop, Brittany A DeVasure, Isabelle Coppens, Isabelle Derré
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010818 (2022)
All Chlamydia species are obligate intracellular bacteria that undergo a unique biphasic developmental cycle strictly in the lumen of a membrane bound compartment, the inclusion. Chlamydia specific Type III secreted effectors, known as inclusion memb
Externí odkaz:
https://doaj.org/article/9f148e7b575641b78a4f76a1c7faafc4
Autor:
Joshua Mayoral, Rebekah B. Guevara, Yolanda Rivera-Cuevas, Vincent Tu, Tadakimi Tomita, Julia D. Romano, Leslie Gunther-Cummins, Simone Sidoli, Isabelle Coppens, Vernon B. Carruthers, Louis M. Weiss
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The intracellular parasite Toxoplasma gondii adapts to diverse host cell environments within a replicative compartment that is heavily decorated by secreted proteins. In an attempt to identify novel parasite secreted proteins that influence
Externí odkaz:
https://doaj.org/article/a0a4d9258960439ea8a171b1b9cb0df0
Publikováno v:
eLife, Vol 11 (2022)
Membrane contact sites (MCS) are crucial for nonvesicular trafficking-based interorganelle communication. Endoplasmic reticulum (ER)–organelle tethering occurs in part through the interaction of the ER resident protein VAP with FFAT motif-containin
Externí odkaz:
https://doaj.org/article/8bbf0a1ad8b144d7be08b21ec306f277