Výsledky vyhledávání - "Isabelle, Bécam"

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

Autor: Marina Gonçalves-Antunes, Matthieu Sanial, Vincent Contremoulins, Sandra Carvalho, Anne Plessis, et Isabelle Bécam

Publikováno v: eLife. 11

SUMMARYThe oncogenic GPCR Smoothened is a key transducer of the Hedgehog morphogen, which plays essential roles in the patterning of epithelial structures. Here, we examine how Hedgehog controls Smoothened subcellular localization and activity in a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c63ffc95e45a137c76cb3a44da4f5e
https://pubmed.ncbi.nlm.nih.gov/36083801

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Dose-dependent transduction of Hedgehog relies on phosphorylation-based feedback between the G-protein-coupled receptor Smoothened and the kinase Fused

Autor: Matthieu, Sanial, Isabelle, Bécam, Line, Hofmann, Julien, Behague, Camilla, Argüelles, Vanessa, Gourhand, Lucia, Bruzzone, Robert A, Holmgren, Anne, Plessis

Publikováno v: Development (Cambridge, England). 144(10)

Smoothened (SMO) is a G-protein-coupled receptor-related protein required for the transduction of Hedgehog (HH). The HH gradient leads to graded phosphorylation of SMO, mainly by the PKA and CKI kinases. How thresholds in HH morphogen regulate SMO to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a381b32909ed5a4545cee6b2c5b53bb6
https://pubmed.ncbi.nlm.nih.gov/28360132

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[Genetic control of intercellular adhesion or how cadherins shape the fruitfly Drosophila melanogaster]

Autor: Isabelle, Bécam, Jean-René, Huynh

Publikováno v: Medecine sciences : M/S. 23(3)

The beauty and diversity of cell shapes have always fascinated both biologists and physicists. In the early 1950, J. Holtfreter coined the term "tissue affinities" to describe the forces behind the spontaneous shaping of groups of cells. These tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::00ebfb66f95c53bcdc20ffeb992e03f7
https://pubmed.ncbi.nlm.nih.gov/17349290

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Control of g2/m transition by Drosophila fos

Autor: Joogyung Hyun, Dirk Bohmann, Constantin Yanicostas, Isabelle Bécam

Publikováno v: Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2006, 26 (22), pp.8293-302. ⟨10.1128/MCB.02455-05⟩

International audience; The transcription factors of the Fos family have long been associated with the control of cell proliferation, although the molecular and cellular mechanisms that mediate this function are poorly understood. We investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8598e66b6bde5fd0f58301586210b346
https://hal.archives-ouvertes.fr/hal-00095756

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