Zobrazeno 1 - 10
of 291
pro vyhledávání: '"Isabelle, André"'
Autor:
Nataël Sorel, Francisco Díaz-Pascual, Boris Bessot, Hanem Sadek, Chloé Mollet, Myriam Chouteau, Marco Zahn, Irene Gil-Farina, Parisa Tajer, Marja van Eggermond, Dagmar Berghuis, Arjan C. Lankester, Isabelle André, Richard Gabriel, Marina Cavazzana, Kasrin Pike-Overzet, Frank J. T. Staal, Chantal Lagresle-Peyrou
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1495 (2024)
Recombinase-activating gene (RAG)-deficient SCID patients lack B and T lymphocytes due to the inability to rearrange immunoglobulin and T cell receptor genes. The two RAG genes act as a required dimer to initiate gene recombination. Gene therapy is a
Externí odkaz:
https://doaj.org/article/4a78380a81614b73972ca4a329e27f1f
Autor:
Xixian Chen, Rehka T, Jérémy Esque, Congqiang Zhang, Sudha Shukal, Chin Chin Lim, Leonard Ong, Derek Smith, Isabelle André
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Retrosynthetic pathway design using promiscuous enzymes can provide a solution to the biosynthetic production of natural products. Here, the authors design a pathway for the production of cis-α-irone with a promiscuous methyltransferase using struct
Externí odkaz:
https://doaj.org/article/913a9e6923b0454cb3e5d54b2cd70510
Autor:
Juliette Leon, Kaitavjeet Chowdhary, Wenxiang Zhang, Ricardo N. Ramirez, Isabelle André, Sun Hur, Diane Mathis, Christophe Benoist
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 113018- (2023)
Summary: Mutations of the transcription factor FoxP3 in patients with “IPEX” (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome) disrupt regulatory T cells (Treg), causing an array of multiorgan autoimmunity. To understand
Externí odkaz:
https://doaj.org/article/f923e572644745f8abd0faaa4e0297aa
Autor:
Baptiste Lamarthée, Armance Marchal, Soëli Charbonnier, Tifanie Blein, Juliette Leon, Emmanuel Martin, Lucas Rabaux, Katrin Vogt, Matthias Titeux, Marianne Delville, Hélène Vinçon, Emmanuelle Six, Nicolas Pallet, David Michonneau, Dany Anglicheau, Christophe Legendre, Jean-Luc Taupin, Ivan Nemazanyy, Birgit Sawitzki, Sylvain Latour, Marina Cavazzana, Isabelle André, Julien Zuber
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Chimeric antigen receptor engineering in T cells has been shown to be of great potential therapeutic benefit in a range of immune pathologies, although the functionality of such cell therapies can be limited due to tonic signalling and the induction
Externí odkaz:
https://doaj.org/article/ff953c0676e145dc93bb84de2244c04f
Autor:
Mounir Benkoulouche, Akli Ben Imeddourene, Louis-Antoine Barel, Dorian Lefebvre, Mathieu Fanuel, Hélène Rogniaux, David Ropartz, Sophie Barbe, David Guieysse, Laurence A. Mulard, Magali Remaud-Siméon, Claire Moulis, Isabelle André
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Enzyme engineering approaches have allowed to extend the collection of enzymatic tools available for synthetic purposes. However, controlling the regioselectivity of the reaction remains challenging, in particular when dealing with carbohydr
Externí odkaz:
https://doaj.org/article/6fca7743f5704259be614afb146d57e5
Autor:
Pierre Gaudeaux, Ranjita Devi Moirangthem, Aurélie Bauquet, Laura Simons, Akshay Joshi, Marina Cavazzana, Olivier Nègre, Shabi Soheili, Isabelle André
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of preference for numerous malignant and non-malignant hemopathies. The outcome of this approach is significantly hampered by not only graft-versus-host disease (GvHD), but al
Externí odkaz:
https://doaj.org/article/67eb6efd9fab41a28bcc937331ffecb7
Autor:
Mounir Benkoulouche, Akli Ben Imeddourene, Louis-Antoine Barel, Guillaume Le Heiget, Sandra Pizzut, Hanna Kulyk, Floriant Bellvert, Sophie Bozonnet, Laurence A. Mulard, Magali Remaud-Siméon, Claire Moulis, Isabelle André
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The (chemo-)enzymatic synthesis of oligosaccharides has been hampered by the lack of appropriate enzymatic tools with requisite regio- and stereo-specificities. Engineering of carbohydrate-active enzymes, in particular targeting the enzyme a
Externí odkaz:
https://doaj.org/article/ef2c88e7c7fc466baca624798a644eb8
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 7, Pp 650-657 (2019)
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice for a large number of malignant and nonmalignant (inherited) diseases of the hematopoietic system. Nevertheless, non‐HLA identical transplantations are co
Externí odkaz:
https://doaj.org/article/5afb6be301ca47eb8d30d0495d56e5e7
Autor:
Nidia Moreno-Corona, Loïc Chentout, Lucie Poggi, Romane Thouenon, Cecile Masson, Melanie Parisot, Lou Le Mouel, Capucine Picard, Isabelle André, Marina Cavazzana, Laurence Perrin, Anne Durandy, Saba Azarnoush, Sven Kracker
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Activated PI3-kinase-δ syndrome 2 (APDS2) is caused by autosomal dominant mutations in the PIK3R1 gene encoding the p85α, p55α, and p50α regulatory subunits. Most diagnosed APDS2 patients carry mutations affecting either the splice donor or splic
Externí odkaz:
https://doaj.org/article/7550814d44e942aba4bf0bf01ddc33f7
Autor:
Mercedes Alfonso-Prieto, Irene Cuxart, Gabrielle Potocki-Véronèse, Isabelle André, Carme Rovira
Publikováno v:
ACS catalysis 13, 4283-4289 (2023). doi:10.1021/acscatal.3c00451
The unknown human gut bacterium mannoside phosphorylase (UhgbMP) is involved in the metabolization of eukaryotic N-glycans lining the intestinal epithelium, a factor associated with the onset and symptoms of inflammatory bowel diseases. In contrast w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b98e387cacf2179b8f83412c94b630d
https://doi.org/10.1021/acscatal.3c00451
https://doi.org/10.1021/acscatal.3c00451