1147-F Human endogenous retrovirus-K proteins form VLPs with dense envelope incorporation – explaining HERV-K immunogenicity in patients and yielding a tool for breaking tolerance to HERV envelope proteins

Autor: Per thor Straten, Ralf Wagner, Peter Holst, Louise Turner, Amaia V Bermejo, Isabella Skandorff, Lasse Neukirch, Jasmin Gille, Frederik O Bagger, Karen N Nielsen, Joana Daradoumis, Charlie R Ince, Lara Duvnjak, Mikkel D Müller, Silke Schrödel, Kaare Grunddal, Kristoffer Staahl Rohrberg, Christian Thirion, Anne-Marie Andersson, Emeline Ragonnaud

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)

Externí odkaz: https://doaj.org/article/6005f92247f24444a2644dd3773cfafa

An Endogenous Retrovirus Vaccine Encoding an Envelope with a Mutated Immunosuppressive Domain in Combination with Anti-PD1 Treatment Eradicates Established Tumours in Mice

Autor: Joana Daradoumis, Emeline Ragonnaud, Isabella Skandorff, Karen Nørgaard Nielsen, Amaia Vergara Bermejo, Anne-Marie Andersson, Silke Schroedel, Christian Thirion, Lasse Neukirch, Peter Johannes Holst

Publikováno v: Viruses, Vol 15, Iss 4, p 926 (2023)

Endogenous retroviruses (ERVs) account for 8% of our genome, and, although they are usually silent in healthy tissues, they become reactivated and expressed in pathological conditions such as cancer. Several studies support a functional role of ERVs

Externí odkaz: https://doaj.org/article/865093eda5b24acd842bb11e17ec108b

Trafficking, localization and degradation of the Na+,HCO3- Co-transporter NBCn1 in kidney and breast epithelial cells

Autor: Julie Schnipper, Marc Severin, Isabella Skandorff Pedersen, Christina W. Olesen, Dan Ploug Christensen, Ida Axholm, Stine F. Pedersen, Jens Vogensen, Jakob Hjorth von Stemann, Jacob M. Schrøder

Publikováno v: Olesen, C W, Vogensen, J, Axholm, I, Severin, M, Schnipper, J, Pedersen, I S, von Stemann, J H, Schrøder, J M, Christensen, D P & Pedersen, S F 2018, ' Trafficking, localization and degradation of the Na +,HCO 3-Co-transporter NBCn1 in kidney and breast epithelial cells ', Scientific Reports, vol. 8, 7435, pp. 1-16 . https://doi.org/10.1038/s41598-018-25059-7
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)

The Na+;HCO3− co-transporter NBCn1 (SLC4A7) is a major regulator of intracellular pH yet its trafficking and turnover are essentially unstudied. Here, we used MDCK-II and MCF-7 cells to investigate these processes in epithelial cells. GFP-NBCn1 mem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd7e1bbb7fec06ba0938d1337293fcb
https://curis.ku.dk/ws/files/211164707/Trafficking_localization_and_degradation_of_the_Na_HCO3_Co_transporter_NBCn1_in_kidney_and_breast_epithelial_cells.pdf