Výsledky vyhledávání - "Isabella Scionti"

Akademický článek

Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation

Autor: Alexis Osseni, Aymeric Ravel-Chapuis, Edwige Belotti, Isabella Scionti, Yann-Gaël Gangloff, Vincent Moncollin, Laetitia Mazelin, Remi Mounier, Pascal Leblanc, Bernard J. Jasmin, Laurent Schaeffer

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Here, authors show that Smad3 acetylation via HDAC6 inhibition reverses Duchenne muscular dystrophy-like symptoms in the mdx mouse model, suggesting a potential therapeutic target for the disorder.

Externí odkaz: https://doaj.org/article/cdf9d7e3e2ad4da9b5e4aa9491b771ee

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Akademický článek

Epigenetic Control of Muscle Stem Cells: Focus on Histone Lysine Demethylases

Autor: Delia Cicciarello, Laurent Schaeffer, Isabella Scionti

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Adult skeletal muscle is mainly composed of post-mitotic, multinucleated muscle fibers. Upon injury, it has the unique ability to regenerate thanks to the activation of a subset of quiescent muscle stem cells (MuSCs). Activated MuSCs either different

Externí odkaz: https://doaj.org/article/f376db1dcc0f44c8bdc1fa5eceb8da48

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Akademický článek

LSD1 Controls Timely MyoD Expression via MyoD Core Enhancer Transcription

Autor: Isabella Scionti, Shinichiro Hayashi, Sandrine Mouradian, Emmanuelle Girard, Joana Esteves de Lima, Véronique Morel, Thomas Simonet, Maud Wurmser, Pascal Maire, Katia Ancelin, Eric Metzger, Roland Schüle, Evelyne Goillot, Frederic Relaix, Laurent Schaeffer

Publikováno v: Cell Reports, Vol 18, Iss 8, Pp 1996-2006 (2017)

MyoD is a master regulator of myogenesis. Chromatin modifications required to trigger MyoD expression are still poorly described. Here, we demonstrate that the histone demethylase LSD1/KDM1a is recruited on the MyoD core enhancer upon muscle differen

Externí odkaz: https://doaj.org/article/df842c1b9ad94a8c89dc918ed4dc92ec

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Data from Overcoming Glutathione S-Transferase P1–Related Cisplatin Resistance in Osteosarcoma

Autor: Massimo Serra, Piero Picci, Katia Scotlandi, Anna Maria Caccuri, Monia Zuntini, Claudia Maria Hattinger, Isabella Scionti, Francesca Michelacci, Michela Pasello

Cisplatin (cis-diamminedichloroplatinum, CDDP) is one of the most used drugs for osteosarcoma chemotherapy. By using a series of CDDP-resistant variants, which were established from the U-2OS and Saos-2 human osteosarcoma cell lines, we found that CD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9643291d52d7731c7b21ef50846128ea
https://doi.org/10.1158/0008-5472.c.6497706

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LSD1 controls a nuclear checkpoint in Wnt/β-Catenin signaling to regulate muscle stem cell self renewal

Autor: Sandrine Mouradian, Delia Cicciarello, Nicolas Lacoste, Francesca Berretta, Fabien Le Grand, Nicolas Rose, Laurent Schaeffer, Isabella Scionti

The Wnt/β-Catenin pathway plays a key role in cell fate determination during development and in adult tissue regeneration by stem cells. These processes involve profound gene expression and epigenome remodeling and linking Wnt/β-Catenin signaling t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0f84b9a69314f40b37301de6f49bf94
https://doi.org/10.1101/2022.06.10.495614

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