Polygenic risk score for hypercholesterolemia in a Brazilian familial hypercholesterolemia cohort

Autor: Isabella Ramos Lima, Mauricio Teruo Tada, Theo G.M. Oliveira, Cinthia Elim Jannes, Isabela Bensenor, Paulo A. Lotufo, Raul D. Santos, Jose E. Krieger, Alexandre C. Pereira

Publikováno v: Atherosclerosis Plus, Vol 49, Iss , Pp 47-55 (2022)

Background and aims: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of LDL-C leading to premature cardiovascular disease (CAD). Only about 40% of individuals with a clinical diagnosis of FH have a causative gene

Externí odkaz: https://doaj.org/article/91bd4a9f5d294aae81f1d9573bdd8f2f

Genome-Wide Association of Proprotein Convertase Subtilisin/Kexin Type 9 Plasma Levels in the ELSA-Brasil Study

Autor: Isabela Bensenor, Kallyandra Padilha, Isabella Ramos Lima, Raul Dias Santos, Gilles Lambert, Stéphane Ramin-Mangata, Marcio S Bittencourt, Alessandra C Goulart, Itamar S. Santos, Jose G Mill, Jose E Krieger, Paulo A. Lotufo, Alexandre C. Pereira

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

Pharmacological inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9) is an established therapeutic option to treat hypercholesterolemia, and plasma PCSK9 levels have been implicated in cardiovascular disease incidence. A number of gene

Externí odkaz: https://doaj.org/article/40ce06bc30634a589f2163df9294e2a7

Adherence to a Mediterranean diet, dyslipidemia and inflammation in familial hypercholesterolemia

Autor: José Eduardo Krieger, Mauricio Teruo Tada, Alexandre C. Pereira, Raquel Arroyo-Olivares, Ovidio Muñiz-Grijalvo, Luiza Antoniazzi, Márcio Sommer Bittencourt, Pedro Mata, José Luis Díaz-Díaz, Cinthia E. Jannes, Isabella Ramos Lima, Gracia M. Quintana-Navarro, Rodrigo Alonso, Raul D. Santos

Publikováno v: Nutrition, Metabolism and Cardiovascular Diseases. 31:2014-2022

Familial Hypercholesterolemia (FH) is characterized by elevated LDL-cholesterol (LDL-C) and high atherosclerosis risk. The impact of different dietary patterns on atherosclerosis biomarkers has been poorly studied in FH. This study verified the assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b63891f7bb49b7ec35d551ab32fb2b
https://doi.org/10.1016/j.numecd.2021.04.006

Screening of

Autor: Mauricio Teruo, Tada, Viviane Zorzanelli, Rocha, Isabella Ramos, Lima, Théo Gremen Mimary, Oliveira, Ana Paula, Chacra, Marcio Hiroshi, Miname, Valéria Sutti, Nunes, Edna Regina, Nakandakare, Maria Helane, Costa Gurgel Castelo, Cinthia Elim, Jannes, Raul D, Santos, José Eduardo, Krieger, Alexandre Costa, Pereira

Publikováno v: Circulation. Genomic and precision medicine. 15(3)

Sitosterolemia is a rare autosomal recessive disorder caused by homozygous or compound heterozygous variants inFrom 443 familial hypercholesterolemia index cases, 260 were negative for familial hypercholesterolemia genes and were sequenced for theEig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff5b49694709b5d672b6887bc56e8c76
https://pubmed.ncbi.nlm.nih.gov/35549507

Rastreamento para Hipercolesterolemia Familiar em Pequenos Municípios: A Experiência do Programa HipercolBrasil em 11 Municípios Brasileiros

Autor: Mauricio Teruo Tada, Pãmela Rodrigues de Souza Silva, Alexandre Costa Pereira, Isabella Ramos Lima, Theo G M Oliveira, Raul D. Santos, José Eduardo Krieger, Cinthia E. Jannes, Júnea Paolucci de Paiva Silvino

Publikováno v: Arquivos Brasileiros de Cardiologia n.ahead 2022
Arquivos Brasileiros de Cardiologia
Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
Arquivos Brasileiros de Cardiologia, Volume: 118, Issue: 4, Pages: 669-677, Published: 07 FEB 2022
Arquivos Brasileiros de Cardiologia (2022)
Arquivos Brasileiros de Cardiologia v.118 n.4 2022

Resumo Fundamento A hipercolesterolemia familiar (HF) é uma doença genética dominante que se caracteriza por níveis sanguíneos elevados de colesterol de lipoproteína de baixa densidade (LDL-C), e está associada à ocorrência de doença cardio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063ea5da7f30ab45304cec474337bc20
https://doi.org/10.36660/abc.20201371