Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Isabella Pugliesi"'
Autor:
Barbara Cosimelli, Giovanni Greco, Chiara Giacomelli, Simona Daniele, Ettore Novellino, Maria Letizia Trincavelli, Sabrina Taliani, Elda Severi, Isabella Pugliesi, Claudia Martini, Elisabetta Barresi, Federico Da Settimo, Sonia Laneri
Background Among adenosine receptors (ARs) the A 2B subtype exhibits low affinity for the endogenous agonist compared with the A 1 , A 2A , and A 3 subtypes and is therefore activated when concentrations of adenosine increase to a large extent follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1218a4734e3ad5a32e28debda1079c1d
http://hdl.handle.net/11568/366467
http://hdl.handle.net/11568/366467
Autor:
Claudia Martini, F Porchia, Annette Gilchrist, A. Fazzini, Sabrina Taliani, M.L. Trincavelli, Simona Daniele, Isabella Pugliesi, S Asteriti, Mazzoni, MT Dell'Anno
Publikováno v:
British Journal of Pharmacology. 167:80-94
BACKGROUND AND PURPOSE Recently, a small molecule (Q94) was reported to selectively block PAR1/Gαq interaction and signalling. Here, we describe the pharmacological properties of Q94 and two analogues that share its benzimidazole scaffold (Q109, Q89
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23d5a925e496156e7551effb06d58eb0
https://doi.org/10.1111/j.1476-5381.2012.01974.x
https://doi.org/10.1111/j.1476-5381.2012.01974.x
Autor:
Valeria La Pietra, Sabrina Taliani, Hideaki Nagase, Elisa Nuti, Robert Visse, Federico Da Settimo, Francesco Saverio Di Leva, Ettore Novellino, Luciana Marinelli, Concettina La Motta, Salvatore Santamaria, Sandro Cosconati, Matteo Morelli, Armando Rossello, F Casalini, Isabella Pugliesi
Publikováno v:
European Journal of Medicinal Chemistry. 47:143-152
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly patients, and is characterized by progressive loss of articular cartilage. Among the various matrix metalloproteinases (MMPs), MMP-13 is specifically exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7777138b02eecc0f72860ec171aadc0
https://doi.org/10.1016/j.ejmech.2011.10.035
https://doi.org/10.1016/j.ejmech.2011.10.035
Publikováno v:
ResearcherID
The A(3) adenosine receptors (A(3) ARs), belonging to the adenosine receptor family of G-protein-coupled receptors (GPCRs), are ubiquitously expressed in a wide variety of tissues in human body, with high levels in peripheral organs and low levels in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951484753d0064308f7ab546f2354168
https://doi.org/10.2174/156802610791293109
https://doi.org/10.2174/156802610791293109
Autor:
Sabrina Taliani, Barbara Cosimelli, Elda Severi, Chiara Giacomelli, Isabella Pugliesi, Elisabetta Barresi, Giovanni Greco, Maria Letizia Trincavelli, Ettore Novellino, Claudia Martini, Sonia Laneri, Simona Daniele, Federico Da Settimo
We have disclosed a series of 1-benzyl-3-ketoindole derivatives acting as either positive or negative modulators of the human A(2B) adenosine receptor (A(2B) AR) depending on small differences in their side chain. The new compounds were designed taki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e93f01f02c0dbd4d23c289e20ed9d1a
http://hdl.handle.net/11568/260135
http://hdl.handle.net/11568/260135
Autor:
Anna Maria Marini, Christophe Marchand, Keli Agama, Luciana Marinelli, Concettina La Motta, Francesco Saverio Di Leva, Sabrina Taliani, Ettore Novellino, Silvia Salerno, Yves Pommier, Roberto Di Santo, Elisabetta Barresi, Federico Da Settimo, Francesca Simorini, Sandro Cosconati, Isabella Pugliesi
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2013, 56 (18), pp.7458-62. ⟨10.1021/jm400932c⟩
Journal of Medicinal Chemistry, American Chemical Society, 2013, 56 (18), pp.7458-62. ⟨10.1021/jm400932c⟩
In search for a novel chemotype to develop topoisomerase I (Top1) inhibitors, the pyrazolo[1,5-a]quinazoline nucleus, structurally related to the indenoisoquinoline system precursor of well-known Top1 poisons, was variously decorated (i.e., a substit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77cf2573334abbb798d1767aa892d39
http://hdl.handle.net/11573/681652
http://hdl.handle.net/11573/681652
Autor:
Vincenzo Calderone, Lara Testai, Giulia Nesi, Elisabetta Barresi, Sabrina Taliani, Alice Marino, Federico Da Settimo, Alma Martelli, Simona Rapposelli, Valentina Citi, Isabella Pugliesi, Maria Cristina Breschi
Publikováno v:
ACS medicinal chemistry letters, Vol. 4, no.10, p. 904-8 (2013)
A small library of arylthioamides 1-12 was easily synthesized, and their H2S-releasing properties were evaluated both in the absence or in the presence of an organic thiol such as l-cysteine. A number of arylthioamides (1-3 and 7) showed a slow and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52580c091032f715efec8cb05887a094
http://hdl.handle.net/11568/274735
http://hdl.handle.net/11568/274735
Autor:
Sabrina, Taliani, Isabella, Pugliesi, Elisabetta, Barresi, Francesca, Simorini, Silvia, Salerno, Concettina, La Motta, Anna Maria, Marini, Barbara, Cosimelli, Sandro, Cosconati, Salvatore, Di Maro, Luciana, Marinelli, Simona, Daniele, Maria Letizia, Trincavelli, Giovanni, Greco, Ettore, Novellino, Claudia, Martini, Federico, Da Settimo
Publikováno v:
Journal of medicinal chemistry. 55(4)
In an effort to identify novel ligands possessing high affinity and selectivity for the A(2B) AR subtype, we further investigated the class of 3-aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones V, previously disclosed by us as selective A(1) AR ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3b05a923789981cbe18fe7c9fd5c36a9
https://pubmed.ncbi.nlm.nih.gov/22257095
https://pubmed.ncbi.nlm.nih.gov/22257095
Autor:
Barbara Cosimelli, Federico Da Settimo, Ettore Novellino, Salvatore Di Maro, Sabrina Taliani, Giovanni Greco, Simona Daniele, Claudia Martini, Anna Maria Marini, Silvia Salerno, Francesca Simorini, Maria Letizia Trincavelli, Elisabetta Barresi, Isabella Pugliesi, Luciana Marinelli, Concettina La Motta, Sandro Cosconati
In an effort to identify novel ligands possessing high affinity and selectivity for the A2B AR subtype, we further investigated the class of 3-aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones V, previously disclosed by us as selective A1 AR antagon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564b133252d874fa73284862d00aeabd
http://hdl.handle.net/11588/423748
http://hdl.handle.net/11588/423748
Autor:
Ciro Milite, Giorgio Stefancich, Claudia Martini, Elisa Rizzetto, Eleonora Da Pozzo, S Bendinelli, Federico Da Settimo, Barbara Costa, Sabrina Taliani, Sandro Cosconati, Giovanni Greco, Isabella Pugliesi, Ettore Novellino, Gianluca Sbardella, Sabrina Castellano
A series of novel 4-phenylquinazoline-2-carboxamides (1-58) were designed as aza-isosters of PK11195, the well-known 18 kDa translocator protein (TSPO) reference ligand, and synthesized by means of a very simple and efficient procedure. A number of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea339886a20670d2c694f561e90338b
http://hdl.handle.net/11591/187321
http://hdl.handle.net/11591/187321