Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Isabella Ponzanelli"'
Autor:
Alessandro Borgonovo, Pascale R. Romano, Andrea Disanza, Gioacchin Iannolo, Giorgio Scita, Isabella Ponzanelli, Nina Offenhäuser, Pier Paolo Di Fiore
Publikováno v:
Molecular Biology of the Cell. 15:91-98
Sos-1, a guanine nucleotide exchange factor (GEF), eps8 and Abi1, two signaling proteins, and the lipid kinase phosphoinositide 3-kinase (PI3-K), assemble in a multimolecular complex required for Rac activation leading to actin cytoskeletal remodelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fec58df472c23b2eaa88470974f921
https://doi.org/10.1091/mbc.e03-06-0427
https://doi.org/10.1091/mbc.e03-06-0427
Autor:
Saskia M. Brachmann, Isabella Ponzanelli, John R. Falck, Pier Paolo Di Fiore, Giorgio Scita, Emanuela Frittoli, Metello Innocenti
Publikováno v:
The Journal of Cell Biology
Class I phosphoinositide 3-kinases (PI3Ks) are implicated in many cellular responses controlled by receptor tyrosine kinases (RTKs), including actin cytoskeletal remodeling. Within this pathway, Rac is a key downstream target/effector of PI3K. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b896a06a2ec814d09cb54c7f4a1c795f
https://doi.org/10.1083/jcb.200206079
https://doi.org/10.1083/jcb.200206079
Autor:
Pier Paolo Di Fiore, Liliana B. Areces, Isabella Ponzanelli, Patrizia Sini, Giuseppina Giardina, Emanuela Frittoli, Pierluigi Tenca, Metello Innocenti, Giorgio Scita, Arianna Tocchetti
Publikováno v:
The Journal of Cell Biology
Genetic and biochemical evidence demonstrated that Eps8 is involved in the routing of signals from Ras to Rac. This is achieved through the formation of a tricomplex consisting of Eps8–E3b1–Sos-1, which is endowed with Rac guanine nucleotide exch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7e390aca4815fc6af3651f3399b014
https://doi.org/10.1083/jcb.200103146
https://doi.org/10.1083/jcb.200103146
Autor:
Enrico Garattini, Maurizio Gianni, Yesim Kalac, Alessandro Rambaldi, Isabella Ponzanelli, Mineko Terao
Publikováno v:
Blood. 97:3234-3243
The 2-phenylaminopyrimidine derivative STI571 is a selective inhibitor of c-Abl, c-kit, and platelet-derived growth factor–receptor tyrosine kinases and is presently in phase II-III clinical studies. Here, this study reports on a novel pharmacologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b02aeda446850ca101963c388d97af
https://doi.org/10.1182/blood.v97.10.3234
https://doi.org/10.1182/blood.v97.10.3234
Autor:
Enrico Garattini, Mineko Terao, Maurizio Gianni, Alessandro Rambaldi, Isabella Ponzanelli, Luca Mologni, Uwe Reichert
Publikováno v:
Cell Death & Differentiation. 7:447-460
In the NB4 model of acute promyelocytic leukemia (APL), ATRA, 9-cis retinoic acid (9-cis RA), the pan-RAR and RARalpha-selective agonists, TTNPB and AM580, induce growth inhibition, granulocytic differentiation and apoptosis. By contrast, two RXR ago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc693ca4aae44fb8446f3a5fef8a3fed
https://doi.org/10.1038/sj.cdd.4400673
https://doi.org/10.1038/sj.cdd.4400673
Autor:
Mineko Terao, Enrico Garattini, Maurizio Gianni, Eugenio Erba, Raffaella Giavazzi, Angela Garofalo, Isabella Ponzanelli, Ines Nicoletti, Uwe Reichert, Alessandro Rambaldi
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) is a novel compound that represents the prototype of a new class of synthetic retinoids with apoptogenic properties in acute promyelocytic leukemia (APL) and other types of leukemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f37810cc1354873c783adcc78a5ff8c
https://doi.org/10.1182/blood.v95.8.2672.008k14_2672_2682
https://doi.org/10.1182/blood.v95.8.2672.008k14_2672_2682
Autor:
Genziana Cipollini, Roberto Barale, Hannu Norppa, Isabella Ponzanelli, Stefano Landi, Ari Hirvonen, Giada Frenzilli
Publikováno v:
Pharmacogenetics. 8:461-472
Although some blood parameters have been suggested to modulate in-vitro induction of sister chromatid exchanges by 1,2:3,4-diepoxybutane (DEB), a metabolite of 1,3-butadiene, the increased sensitivity has largely been assigned to a homozygous deletio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a887f3d0d58ae455bcc1f9810e1d9779
https://doi.org/10.1097/00008571-199812000-00002
https://doi.org/10.1097/00008571-199812000-00002
Publikováno v:
Scopus-Elsevier
All-trans retinoic acid (ATRA) and interferons (IFNs) are active anticancer agents. ATRA is capable of inducing complete remission in acute promyelocytic leukemia (APL) patients, whereas IFNalpha is successfully used in the treatment of the stable ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b95eeece208770a3fe5bd78b33dcfd
https://doi.org/10.3109/10428199809057559
https://doi.org/10.3109/10428199809057559
Publikováno v:
Mutation Research Letters. 348:117-123
Previous authors investigated individual responsiveness to mutagens by assessing cytogenetic damage following gin vitro treatment. Diepoxybutane (DEB) has been used to assess chromosome instability both in repair-deficient and normal subjects. Since
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65037eae66a3aeb0e0af8b2b0bb5b6ac
https://doi.org/10.1016/0165-7992(95)00055-0
https://doi.org/10.1016/0165-7992(95)00055-0
Publikováno v:
Mutation Research Letters. 346:93-97
Many studies on DNA repair mechanisms in mammalian cells have used liquid holding (LH) recovery to evaluate premutational damage repair. We used human peripheral lymphocytes (HPL) to assess damage reduction during the G0 phase. This technique was mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3abf916d778ca3452e7bc5430f9d6de
https://doi.org/10.1016/0165-7992(95)90056-x
https://doi.org/10.1016/0165-7992(95)90056-x