IL-33 stimulates the anticancer activities of eosinophils through extracellular vesicle-driven reprogramming of tumor cells

Autor: Adriana Rosa Gambardella, Caterina Antonucci, Cristiana Zanetti, Francesco Noto, Sara Andreone, Davide Vacca, Valentina Pellerito, Chiara Sicignano, Giuseppe Parrottino, Valentina Tirelli, Antonella Tinari, Mario Falchi, Adele De Ninno, Luca Businaro, Stefania Loffredo, Gilda Varricchi, Claudio Tripodo, Claudia Afferni, Isabella Parolini, Fabrizio Mattei, Giovanna Schiavoni

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-25 (2024)

Abstract Immune cell-derived extracellular vesicles (EV) affect tumor progression and hold promise for therapeutic applications. Eosinophils are major effectors in Th2-related pathologies recently implied in cancer. Here, we evaluated the anti-tumor

Externí odkaz: https://doaj.org/article/9b0f9646ff2d4fdcab61db2ede19e22c

Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Autor: Zaira Boussadia, Jessica Lamberti, Fabrizio Mattei, Elisabetta Pizzi, Rossella Puglisi, Cristiana Zanetti, Luca Pasquini, Federica Fratini, Luca Fantozzi, Federica Felicetti, Katia Fecchi, Carla Raggi, Massimo Sanchez, Stefania D’Atri, Alessandra Carè, Massimo Sargiacomo, Isabella Parolini

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-15 (2018)

Abstract Background Microenvironment cues involved in melanoma progression are largely unknown. Melanoma is highly influenced in its aggressive phenotype by the changes it determinates in its microenvironment, such as pH decrease, in turn influencing

Externí odkaz: https://doaj.org/article/5c07a597b7c24b0fbd1f681ae47f557b

Role of microenvironmental acidity and tumor exosomes in cancer immunomodulation

Autor: Zaira Boussadia, Isabella Parolini, Cristiana Zanetti

Publikováno v: Translational Cancer Research

Tumor microenvironment (TME) is a complex milieu in which tumor grows, develops and progresses through a complex bi-directional cross-talk with immune-, stromal cells, and the extracellular matrix (ECM). In this context, tumor-derived exosomes (TE) d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7346a7b073fd043ac63e6883d8c673e9
https://doi.org/10.21037/tcr.2020.03.69

Combining Type I Interferons and 5-Aza-2′-Deoxycitidine to Improve Anti-Tumor Response against Melanoma

Autor: Francesca Peschiaroli, Alberto Rainer, Daniele Macchia, Maria Teresa D'Urso, Annamaria Gerardino, Gianfranco Mattia, Iole Macchia, Adele De Ninno, Luca Businaro, Marcella Trombetta, Paola Sestili, Valeria Lucarini, Fabrizio Mattei, Laura Bracci, Giovanna Schiavoni, Rossella Puglisi, Pamela Mozetic, Massimo Spada, Giovanna Ziccheddu, Isabella Parolini, Alessandra Rossi, Carla Buccione, Cristiana Zanetti

Publikováno v: Journal of investigative dermatology 137 (2017): 159–169. doi:10.1016/j.jid.2016.08.024
info:cnr-pdr/source/autori:Lucarini, Valeria; Buccione, Carla; Ziccheddu, Giovanna; Peschiaroli, Francesca; Sestili, Paola; Puglisi, Rossella; Mattia, Gianfranco; Zanetti, Cristiana; Parolini, Isabella; Bracci, Laura; Macchia, Iole; Rossi, Alessandra; D'Urso, Maria Teresa; Macchia, Daniele; Spada, Massimo; De Ninno, Adele; Gerardino, Annamaria; Mozetic, Pamela; Trombetta, Marcella; Rainer, Alberto; Businaro, Luca; Schiavoni, Giovanna; Mattei, Fabrizio/titolo:Combining Type I Interferons and 5-Aza-2 '-Deoxycitidine to Improve Anti-Tumor Response against Melanoma/doi:10.1016%2Fj.jid.2016.08.024/rivista:Journal of investigative dermatology/anno:2017/pagina_da:159/pagina_a:169/intervallo_pagine:159–169/volume:137

Resistance to IFN-I–induced antineoplastic effects has been reported in many tumors and arises, in part, from epigenetic silencing of IFN-stimulated genes by DNA methylation. We hypothesized that restoration of IFN-stimulated genes by co-administra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54716c753c0e0347e47f6b4a640a1df
https://doi.org/10.1016/j.jid.2016.08.024

Correction: Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes (doi:10.1242/jcs.02784)

Autor: R Guerriero, Isabella Parolini, Ugo Testa, Cesare Peschle, Eleonora Petrucci, Paola Samoggia, C Chelucci, Marco Gabbianelli, Massimo Sargiacomo

Publikováno v: Journal of Cell Science. 132

This Expression of Concern relates to [J. Cell Sci. (2006) 119, 744-752 (doi:10.1242/jcs.02784)][1]. Journal of Cell Science was informed that several bands in each of the ERK1/2, P-AKT, AKT and p70S6K blots in Fig. 5 look very similar. After discuss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125ed0f50df191e10a54e7285f685f07
https://doi.org/10.1242/jcs.233676