Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Isabella Pörn-Ares"'
Autor:
Simone Grethe, M. Isabella Pörn-Ares
Publikováno v:
Cellular Signalling. 18:531-540
We recently reported that p38 MAPK regulates TNF-induced endothelial apoptosis via phosphorylation and downregulation of Bcl-xL. Here, we describe that such apoptosis includes p38 MAPK-mediated, protein phosphatase 2A (PP2A)-dependent, downregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d8bc9ff2ce0f984d42f63d77ba4c64
https://doi.org/10.1016/j.cellsig.2005.05.023
https://doi.org/10.1016/j.cellsig.2005.05.023
Autor:
M. Isabella Pörn-Ares, Maria M. Stollenwerk, Mikko P.S. Ares, Jan Nilsson, Anna Larsson, Marie W. Lindholm
Publikováno v:
Biochemical and Biophysical Research Communications. 335:603-608
Elevated plasma level of very low-density lipoprotein (VLDL) is a risk factor for coronary heart disease. We investigated the effect of VLDL on expression of the pro-inflammatory cytokine interleukin-1beta (IL-1beta) in human peripheral blood monocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb7a08476e0b6f983b4e47203a96d80
https://doi.org/10.1016/j.bbrc.2005.07.123
https://doi.org/10.1016/j.bbrc.2005.07.123
Publikováno v:
Experimental Cell Research. 298:632-642
The role of p38 mitogen-activated protein kinase (MAPK) in apoptosis is a matter of debate. Here, we investigated the involvement of p38 MAPK in endothelial apoptosis induced by tumor necrosis factor alpha (TNF). We found that activation of p38 MAPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2560f1159d8b1c89d9c3af1e2edcba
https://doi.org/10.1016/j.yexcr.2004.05.007
https://doi.org/10.1016/j.yexcr.2004.05.007
Publikováno v:
Clinical Cancer Research. 10:3179-3188
Purpose: On the basis of clinical studies showing that arsenic trioxide (As2O3), via an apoptotic mechanism, and with minimal toxicity induces complete remission in patients with refractory acute promyelocytic leukemia and that multidrug-resistant an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2be9cf80c5ce8499ec559db75e4ef30
https://doi.org/10.1158/1078-0432.ccr-03-0309
https://doi.org/10.1158/1078-0432.ccr-03-0309
Publikováno v:
Biochemical Journal. 374:403-411
Oxidized low-density lipoprotein (oxLDL) is known to induce apoptosis in endothelial cells, and this is believed to contribute to the progression of atherosclerosis. In the present study we made the novel observation that oxLDL-induced death of HMEC-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360d24786dc431ce5cf9c5361e2306f0
https://doi.org/10.1042/bj20021955
https://doi.org/10.1042/bj20021955
Autor:
Zhong-Qun Yan, Gunilla Nordin Fredrikson, Jan Nilsson, Mikko P.S. Ares, D.-X. Bu, Anna Hultgårdh Nilsson, Lena Brånén, Isabella Pörn-Ares, Audrey Niemann-Jönsson
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 21:1909-1914
Abstract — Intimal proliferation of smooth muscle cells (SMCs) is a key event in the vascular response to injury, including the early stages of atherosclerosis and restenosis after angioplasty. Tumor necrosis factor-α (TNF-α) has been reported to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fe92fce5709a133b2cccb2b195e9dc
https://doi.org/10.1161/hq1201.100222
https://doi.org/10.1161/hq1201.100222
Publikováno v:
Experimental Cell Research. 235:48-54
Apoptosis induced by ligation of either the tumor necrosis factor (TNF) p55 receptor or the Fas/APO-1/CD95 receptor has been suggested to require ceramide as a signaling molecule. Ceramide is formed as a result of sphingomyelinase (SMase) activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7371739b6287af8e1674a57abaf1c3
https://doi.org/10.1006/excr.1997.3641
https://doi.org/10.1006/excr.1997.3641
Publikováno v:
FEBS Letters. 399:277-282
The appearance of phosphatidylserine (PS) on the outer surface of apoptotic cells is an important signal for their ingestion. In platelets, elevation of intracellular Ca2+ with thapsigargin can trigger large amounts of PS exposure within minutes. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c624ec8006fedd7bfcc54810c974e95a
https://doi.org/10.1016/s0014-5793(96)01341-5
https://doi.org/10.1016/s0014-5793(96)01341-5
Autor:
José Fernandes e Fernandes, Isabel Gonçalves, Luís Mendes Pedro, Mikko P.S. Ares, Nuno Dias, Isabella Pörn-Ares, Mihaela Nitulescu, Takaomi C. Saido
Publikováno v:
BMC Cardiovascular Disorders
BMC Cardiovascular Disorders, Vol 9, Iss 1, p 26 (2009)
BMC Cardiovascular Disorders, Vol 9, Iss 1, p 26 (2009)
Background In a previous study, we observed that oxidized low-density lipoprotein-induced death of endothelial cells was calpain-1-dependent. The purpose of the present paper was to study the possible activation of calpain in human carotid plaques, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353147f04af481ad3d52b7b962ee56f9
https://pubmed.ncbi.nlm.nih.gov/19538725
https://pubmed.ncbi.nlm.nih.gov/19538725
Autor:
Ove Eriksson, Jarno Tuimala, Zydrune Polianskyte, James Thompson, Dan Lindholm, Oliver Speer, Julius Liobikas, Nina Peitsaro, Isabella Pörn-Ares
Publikováno v:
BMC Evolutionary Biology, Vol 8, Iss 1, p 26 (2008)
BMC Evolutionary Biology
BMC Evolutionary Biology
BackgroundBacterial penicillin-binding proteins and β-lactamases (PBP-βLs) constitute a large family of serine proteases that perform essential functions in the synthesis and maintenance of peptidoglycan. Intriguingly, genes encoding PBP-βL homolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9f16968f16b72dcb6b8be3b6540e62
https://doi.org/10.1186/1471-2148-8-26
https://doi.org/10.1186/1471-2148-8-26