Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Isabella Nassir"'
1
The JAK1/2 inhibitor ruxolitinib downregulates the immune checkpoint protein B7H3 in multiple myeloma
Autor: Ning Xu, Erin Yu, Nicole Ng, Mingjie Li, Sean Bujarski, Ava Hekmati, Isabella Nassir, Tara Hekmati, Janna Yu, David Daniely, Cathy S. Wang, Clara Kim, Haiming Chen, James R. Berenson
Publikováno v: Hematological oncologyREFERENCES.
We hypothesized that ruxolitinib may inhibit the immune checkpoint protein, B7H3; and, thus, investigated its effects on this immune inhibitor using multiple myeloma (MM) cell lines, bone marrow (BM) mononuclear cells from MM patients and human MM LA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4763d7e2a7f4caee573188fadd9f8f
https://pubmed.ncbi.nlm.nih.gov/36043430
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6
Ruxolitinib reverses checkpoint inhibition by reducing programmed cell death ligand-1 (PD-L1) expression and increases anti-tumour effects of T cells in multiple myeloma
Autor: Haiming Chen, Tanya M. Spektor, Nicole Ng, Janna Yu, James R. Berenson, Mingjie Li, Justin Huang, Cathy Wang, David Daniely, Zhengyi Yin, Sean Bujarski, Isabella Nassir, Ning Xu, Mingxiang Wen, Tara Hekmati, Dylan Field, Jasper Wang, Erin Yu
Publikováno v: British journal of haematologyReferences. 192(3)
Multiple myeloma (MM) tumour cells evade host immunity through a variety of mechanisms, which may potentially include the programmed cell death ligand-1 (PD-L1):programmed cell death protein-1 (PD-1) axis. This interaction contributes to the immunosu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29677fe25566d2a0334d17f371b3cb5
https://pubmed.ncbi.nlm.nih.gov/33341927
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7
Ruxolitinib Reverses Checkpoint Inhibition By Downregulating PD-L1 and PD-L2 Expression on Both Tumor and Stromal Cells in Multiple Myeloma
Autor: Tara Hekmati, Dylan Field, Isabella Nassir, David Daniely, Haiming Chen, Eric Sanchez, Mingjie Li, James R. Berenson, Sean Bujarski, Nicole Ng, Cathy Wang, Ning Xu, Erin Yu, Justin Huang, Janna Yu, Jasper Wang, Zhengyi Yin
Publikováno v: Blood. 134:4402-4402
Introduction: Multiple myeloma (MM) tumor cells evade host immunity through the interaction of PD-L1 and PD-L2 to PD-1 on T-cells. This creates an immunosuppressive milieu in the bone marrow (BM) microenvironment. The immune inhibitory proteins PD-L1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea161c1729654badce6f9dd3c01116c7
https://doi.org/10.1182/blood-2019-130888
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8
The JAK1/2 Inhibitor Ruxolitinib Downregulates the Immune Checkpoint Protein B7-H3 in Multiple Myeloma
Autor: Jasper Wang, Haiming Chen, Mingjie Li, Erin Yu, Nicole Ng, Tara Hekmati, Cathy Wang, Zhengyi Yin, Justin Huang, Dylan Field, Sean Bujarski, Janna Yu, Ning Xu, Eric Sanchez, James R. Berenson, Isabella Nassir, David Daniely
Publikováno v: Blood. 134:1824-1824
Introduction: The JAKSTAT pathway plays a critical role in the regulation of hematopoietic pathways and immunological cytokine signaling. The JAK pathway is also involved in tumor cell proliferation and drug resistance in multiple myeloma (MM). Thus,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29380b125de75d991e931a89d597233c
https://doi.org/10.1182/blood-2019-131047
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9
The JAK1/2 Inhibitor Ruxolitinib Downregulates CXCL12 Secretion from Bone Marrow Stromal Cells and M2 Macrophage Polarization in Multiple Myeloma
Autor: Cathy Wang, Jasper Wang, Zhengyi Yin, Justin Huang, Mingjie Li, David Daniely, Ning Xu, Isabella Nassir, Eric Sanchez, Tara Hekmati, James R. Berenson, Dylan Field, Sean Bujarski, Erin Yu, Nicole Ng, Haiming Chen
Publikováno v: Blood. 134:4352-4352
Introduction: The JAKSTAT pathway plays a critical role in the regulation of hematopoietic pathways and immunological cytokine signaling. The JAK pathway is also involved in tumor cell proliferation and drug resistance in multiple myeloma (MM). Thus,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d78649f0c3f40e190bab38ddfa0c6229
https://doi.org/10.1182/blood-2019-131324
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