Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Isabella Mengarelli"'
Autor:
Arie O. Verkerk, Illés J. Doszpod, Isabella Mengarelli, Tibor Magyar, Alexandra Polyák, Bence Pászti, Igor R. Efimov, Ronald Wilders, István Koncz
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2987 (2022)
Vagal nerve stimulation (VNS) holds a strong basis as a potentially effective treatment modality for chronic heart failure, which explains why a multicenter VNS study in heart failure with reduced ejection fraction is ongoing. However, more detailed
Externí odkaz:
https://doaj.org/article/9d5e58f3a0cb46638f8f2e10772df109
Autor:
Arie O. Verkerk, Suzan J. G. Knottnerus, Vincent Portero, Jeannette C. Bleeker, Sacha Ferdinandusse, Kaomei Guan, Lodewijk IJlst, Gepke Visser, Ronald J. A. Wanders, Frits A. Wijburg, Connie R. Bezzina, Isabella Mengarelli, Riekelt H. Houtkooper
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Patients with a deficiency in very long-chain acyl-CoA dehydrogenase (VLCAD), an enzyme that is involved in the mitochondrial beta-oxidation of long-chain fatty acids, are at risk for developing cardiac arrhythmias. In human induced pluripotent stem
Externí odkaz:
https://doaj.org/article/9bf15979cc1e485ca8dbed0f9ba01156
Autor:
Christiaan C. Veerman, Isabella Mengarelli, Charlotte D. Koopman, Ronald Wilders, Shirley C. van Amersfoorth, Diane Bakker, Rianne Wolswinkel, Mariam Hababa, Teun P. de Boer, Kaomei Guan, James Milnes, Elisabeth M. Lodder, Jeroen Bakkers, Arie O. Verkerk, Connie R. Bezzina
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 7 (2019)
Mutations in GNB5, encoding the G-protein β5 subunit (Gβ5), have recently been linked to a multisystem disorder that includes severe bradycardia. Here, we investigated the mechanism underlying bradycardia caused by the recessive p.S81L Gβ5 variant
Externí odkaz:
https://doaj.org/article/9a0498e951bf479a8ce5b96fc11940df
Autor:
Suzan J. G. Knottnerus, Isabella Mengarelli, Rob C. I. Wüst, Antonius Baartscheer, Jeannette C. Bleeker, Ruben Coronel, Sacha Ferdinandusse, Kaomei Guan, Lodewijk IJlst, Wener Li, Xiaojing Luo, Vincent M. Portero, Ying Ulbricht, Gepke Visser, Ronald J. A. Wanders, Frits A. Wijburg, Arie O. Verkerk, Riekelt H. Houtkooper, Connie R. Bezzina
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2589 (2020)
Patients with very long-chain acyl-CoA dehydrogenase deficiency (VLCADD) can present with life-threatening cardiac arrhythmias. The pathophysiological mechanism is unknown. We reprogrammed fibroblasts from one mildly and one severely affected VLCADD
Externí odkaz:
https://doaj.org/article/9291905b068a4faa9e19d8a94197632a
Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells
Autor:
Maike Marczenke, Ilaria Piccini, Isabella Mengarelli, Jakob Fell, Albrecht Röpke, Guiscard Seebohm, Arie O. Verkerk, Boris Greber
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
The ultrarapid delayed rectifier K+ current (IKur), mediated by Kv1.5 channels, constitutes a key component of the atrial action potential. Functional mutations in the underlying KCNA5 gene have been shown to cause hereditary forms of atrial fibrilla
Externí odkaz:
https://doaj.org/article/a6c531ad6cdc49de92418ae8f227e181
Autor:
Christiaan C. Veerman, Isabella Mengarelli, Elisabeth M. Lodder, Georgios Kosmidis, Milena Bellin, Miao Zhang, Sven Dittmann, Kaomei Guan, Arthur A. M. Wilde, Eric Schulze‐Bahr, Boris Greber, Connie R. Bezzina, Arie O. Verkerk
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 7 (2017)
BackgroundHuman induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs) can recapitulate features of ion channel mutations causing inherited rhythm disease. However, the lack of maturity of these cells is considered a significant limitat
Externí odkaz:
https://doaj.org/article/31b4d470588642f7847c23b8bd417347
Autor:
Arie O. Verkerk, Christiaan C. Veerman, Jan G. Zegers, Isabella Mengarelli, Connie R. Bezzina, Ronald Wilders
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 9, p 1873 (2017)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold great promise for studying inherited cardiac arrhythmias and developing drug therapies to treat such arrhythmias. Unfortunately, until now, action potential (AP) measurements
Externí odkaz:
https://doaj.org/article/43cb6bd06b5e4361b8d4a4d6668ee6ac
Autor:
Simona Casini, Vincent Portero, Gerard A Marchal, Carol Ann Remme, Joris R. de Groot, Fransisca A. Nariswari, Kaomei Guan, Antoine H.G. Driessen, Marieke W. Veldkamp, Arie O. Verkerk, Makiri Kawasaki, Nicoline W.E. van den Berg, Isabella Mengarelli
Publikováno v:
Cardiovascular Drugs and Therapy
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy, 33(6), 649-660. Kluwer Academic Publishers
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy, 33(6), 649-660. Kluwer Academic Publishers
Purpose Several studies have indicated a potential role for SCN10A/NaV1.8 in modulating cardiac electrophysiology and arrhythmia susceptibility. However, by which mechanism SCN10A/NaV1.8 impacts on cardiac electrical function is still a matter of deb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b4ef2ce4fb577a5fa2c0e1f680be0c
https://doi.org/10.1007/s10557-019-06925-6
https://doi.org/10.1007/s10557-019-06925-6
Autor:
Mischa Klerk, Calum A. MacRae, Marta Pérez-Hernández, Elisabeth M. Lodder, Paul W. Burridge, Christiaan C. Veerman, Isabella Mengarelli, Richard Redon, Vincent Portero, Gerard A Marchal, Carol Ann Remme, Mario Delmar, Franck Potet, Flavien Charpentier, Kaomei Guan, Svitlana Podliesna, Nuo Yu, Carlos G. Vanoye, Alfred Lewis George, David Y. Chiang, Niels Galjart, Simona Casini, Mariam Jouni, Arie O. Verkerk, Eli Rothenberg, Connie R. Bezzina
Publikováno v:
Circ Res
Circulation research, 129(3), 349-365. Lippincott Williams and Wilkins
Circulation Research, 129(3), 349-365. Lippincott Williams & Wilkins
Circulation research, 129(3), 349-365. Lippincott Williams and Wilkins
Circulation Research, 129(3), 349-365. Lippincott Williams & Wilkins
Rationale: Loss-of-function of the cardiac sodium channel Na V 1.5 causes conduction slowing and arrhythmias. Na V 1.5 is differentially distributed within subcellular domains of cardiomyocytes, with sodium current ( I Na ) being enriched at the inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ec730de2a7e331c928f42d1d495887
https://europepmc.org/articles/PMC8298292/
https://europepmc.org/articles/PMC8298292/
Autor:
Isabella Mengarelli, Arie O. Verkerk, Francis A. Ortega, Ruben Coronel, David J. Christini, Trine Krogh-Madsen, Edward J. Vigmond, Namit Gaur
Publikováno v:
Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, Elsevier, 2020, 145, pp.122-132. ⟨10.1016/j.yjmcc.2020.04.019⟩
Journal of molecular and cellular cardiology, 145, 122-132. Academic Press Inc.
Journal of Molecular and Cellular Cardiology, Elsevier, 2020, 145, pp.122-132. ⟨10.1016/j.yjmcc.2020.04.019⟩
Journal of molecular and cellular cardiology, 145, 122-132. Academic Press Inc.
Repolarization reserve, the robustness of a cell to repolarize even when one of the repolarization mechanisms is failing, has been described qualitatively in terms of ionic currents, but has not been quantified by a generic metric that is applicable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c82429aefd2325f3b6c2439d8bee68
https://hal.archives-ouvertes.fr/hal-03492208
https://hal.archives-ouvertes.fr/hal-03492208