Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Isabella M. Lico"'
Publikováno v:
Canadian Journal of Chemistry. 70:1323-1327
An alternative synthesis of (±)-7-(3-methylpiperazin-1-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride 4, a potent antibacterial agent, was developed. The method was characterized by regiospecific displ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bff31a68d81810d63bf6d5efcd0663de
https://doi.org/10.1139/v92-170
https://doi.org/10.1139/v92-170
Publikováno v:
The Journal of Organic Chemistry. 53:1580-1582
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4150220a7a7f24e5f8b34f343e5a121b
https://doi.org/10.1021/jo00242a051
https://doi.org/10.1021/jo00242a051
Publikováno v:
ChemInform. 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2f5084c68e0d5b2e1e7d3c3db4051d1
https://doi.org/10.1002/chin.198839177
https://doi.org/10.1002/chin.198839177
Autor:
Linus L. Shen, Valerie G. Cepa, Kennan C. Marsh, Daniel T. W. Chu, Terry Rosen, Andre G. Pernet, Prabhavathi B. Fernandes, Isabella M. Lico
Publikováno v:
Journal of medicinal chemistry. 31(8)
The quinolonecarboxylic acids constitute a class of extremely potent and orally active broad-spectrum antibacterial agents. These compounds have been shown to inhibit DNA gyrase, a key enzyme in bacterial DNA replication. The 7-(3-aminopyrrolidinyl)q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac9d20d6355652554a215927eda10b1
https://pubmed.ncbi.nlm.nih.gov/2840501
https://pubmed.ncbi.nlm.nih.gov/2840501
Autor:
Prabhavathi B. Fernandes, Terry Rosen, Saul. Borodkin, Isabella M. Lico, Daniel T. W. Chu, Linus L. Shen, Andre G. Pernet
Publikováno v:
Journal of medicinal chemistry. 31(8)
Compound 1 [7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-1,4-dihydro-6-f luoro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride] is a potent member of the quinolonecarboxylic acid class of antibacterial agents and is currently undergoing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231016da7d63d9deb1c05085c88b9753
https://pubmed.ncbi.nlm.nih.gov/3397996
https://pubmed.ncbi.nlm.nih.gov/3397996