Zobrazeno 1 - 10
of 277
pro vyhledávání: '"Isabella L. Karle"'
Publikováno v:
Biopolymers. 98:76-86
An 18-residue sequence Boc-Aib-Val-Ala-Leu-Aib-Val-Ala-Leu-Gly-Pro-Val-Ala-Leu-Aib-Val-Ala-Leu-Aib-OMe (UK18) was designed to examine the effect of introducing a Gly-Pro segment into the middle of a potentially helical peptide. The crystal structures
Autor:
Theodor Wieland, Isabella L. Karle
Publikováno v:
International Journal of Peptide and Protein Research
The cyclic decapeptide antamanide and the synthetic, biologically active analog [Phe4 Val6]antamanide (cyclic[ValProProPhePhe]2) crystallize in various crystal forms as a function of the solvent. The present crystalline polymorph obtained from aceton
Autor:
Isabella L. Karle
Publikováno v:
International Journal of Peptide and Protein Research. 28:420-427
All the peptide bonds in cyclic(Gly-L-Pro-D-Phe-Gly-L-Ala) are in the trans conformation; however, the peptide bond C'5-N1 is twisted by 19 degrees from planarity (omega 5 = -161 degrees). A Type II beta-turn encompasses the L-Pro-D-Phe residues. Car
Publikováno v:
International Journal of Peptide and Protein Research. 32:536-543
In the crystal, the backbone of Boc-(Aib-Val-Ala-Leu)2-Aib-OMe adopts a helical form with four alpha-type hydrogen bonds in the middle, flanked by 3(10)-type hydrogen bonds at either end. The helical molecules stack in columns with head-to-tail hydro
Autor:
Isabella L. Karle
Publikováno v:
International Journal of Peptide and Protein Research. 23:32-38
Upon long standing and very slow evaporation, a solution of the cyclic pentapeptide and Mg(SCN)2 in CDCl3/CD3CN produced colorless crystals of a 1:1 complex of the peptide and Mg++. X-ray diffraction analysis showed the contents of the asymmetric uni
Autor:
Darshan Ranganathan, Isabella L. Karle
Publikováno v:
International Journal of Peptide and Protein Research. 46:24-29
The adipoyl- and suberoyl-linked bis(Ala) peptides have an extended backbone between the two C alpha atoms in each molecule. They self-assemble, through intermolecular hydrogen bonds and stacking of parallel strands, into highly ordered modified beta
Autor:
Isabella L. Karle, Miklos Bodanszky
Publikováno v:
International Journal of Peptide and Protein Research. 32:194-199
Ortho-nitrophenyl esters of blocked amino acids have significantly higher aminolysis rates than the corresponding para-nitrophenyl esters. This difference prompted a series of investigations that led to the present study. Single crystal X-ray diffrac
Autor:
Isabella L. Karle
Publikováno v:
International Journal of Peptide and Protein Research. 16:471-476
Different isomers of beta-hydroxy-N-acetyl-tryptophanamide are obtained depending upon the preparative route. The threo (from enzymatic oxidation) and erythro (from synthetic reduction) forms are distinguished further by their conformation, particula
Publikováno v:
International Journal of Peptide and Protein Research. 42:401-410
The crystal structure determination of three heptapeptides containing alpha-aminoisobutyryl (Aib) residues as a means of helix stabilization provides a high-resolution characterization of 6-->1 hydrogen-bonded conformations, reminiscent of helix-term
Autor:
Isabella L. Karle
Publikováno v:
International Journal of Peptide and Protein Research. 28:6-14
Crystals of [Phe4 Val6] antamanide (cyclic [ValProProPhePhe]2) grown from dioxane/H2O, with space group P21212 and cell parameters a = 15.099(4), b = 22.008(5) and c = 11.024(3) A, are almost identical to crystals grown from H2O/acetone, the structur